Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry
Author: Woodcock, Jane C.; Henderson, William; Miles, Christopher O.; Nicholson, Brian K.
Date: 2001
Type: Journal article
Link to this item using this URL: http://hdl.handle.net/10289/159
Abstract
Electrospray ionisation mass spectrometry (ES-MS) has been used to probe the coordination chemistry of metabolites such as sporidesmin D (spdD), found in the saprophytic fungus Pithomyces chartarum, and the related bisdethiobis(methylthio)gliotoxin (dimethylgliotoxin, Megtx). SpdD forms complexes of the type [spdD+M(MeCN)]+ and [2spdD+M]+ (M=Cu, Ag) and, at higher cone voltages, [spdD+M]+. The bis(ligand) ion [2spdD+M]+ was observed at very high cone voltages, indicating it has appreciable stability; the proposed structure of this species has a four-coordinate metal ion with two bidentate spdD ligands, coordinated through their SMe groups. 1H NMR titrations of spdD with K+, Ag+ and Cu+ provided additional evidence for complex formation with the soft metals. SpdD forms only relatively weak complexes with Zn2+, Cd2+, Co2+ and Mn2+, in keeping with the known reduced tendency of these metals to form stable thioether complexes. ES-MS studies of Megtx showed similar results to spdD, with stable adducts formed with Cu+ and Ag+ ions. The X-ray crystal structure of spdD is also reported.
Subjects: Electrospray mass spectrometry, Mycotoxin, Sporidesmin, Gliotoxin, Metal complexes
Citation: ["Woodcock, J.C., Henderson, W. Miles, C.O. & Nicholson, B.K. (2001). Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry. Journal of Inorganic Biochemistry 84(3-4), 225-232."]
Copyright: This article is published in the Journal of Organometallic Chemistry, (c) 2001 Elsevier Science B.V.