3,587 results for The University of Auckland Library, Doctoral

  • Integrated Solutions in the Capital Goods Sector: Exploring Innovation, Service and Network Perspectives

    Windahl, Charlotta (2007)

    Doctoral thesis
    The University of Auckland Library

    With varying degrees of success, a number of firms in the capital goods sector are experimenting with different ‘integrated solutions’ initiatives. Integrated solutions include product innovations which enable increased process control that allows the optimisation of the customers’ processes, as well as business innovations which change the firms’ business models and customer approach. It is not always easy to develop and commercialise these new offerings, especially for firms that have traditionally focused on developing and selling products. Integrated solutions challenge these firms to shift the focus from physical products, spare parts and support services to emphasis on delivery of performance optimisation and productivity. This thesis is a compilation of five papers and five supporting chapters that discuss and analyse the challenges with developing and commercialising integrated solutions in the capital goods sector. The research builds on case studies of firms experimenting with integrated-solution offerings. The firms produce complex, expensive industrial machinery to customers in the process and manufacturing industries. The main case is based on a five-year, in-depth longitudinal study of Alfa Laval, and more specifically of the developments within the wastewater industry. Other case studies include ITT Flygt and Atlas Copco. The thesis shows that the development and commercialisation of integrated solutions represent a multifaceted, iterative and complex process for the firms under study, who need to combine product, service and business innovations, create new business structures, and create new relationships with customers and possible partners. Consequently, the development of integrated solutions is not confined to or explained by one theoretical field in this thesis, but is linked to innovation, service and network perspectives. The thesis also shows that the three activities of innovating, organising and building relationships are dependent on changing market structures, customer demands and business cycles. Therefore it becomes important to manage the coexistence of different types of offerings, such as products, services and integrated solutions.

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  • Strengthening the Capability Approach: The Foundations of the Capability Approach with insights from Two Challenges

    Watene, Krushil (2011)

    Doctoral thesis
    The University of Auckland Library

    The Capability Approach was initially developed by Nobel laureate Amartya Sen, with the first basic articulation presented in his 1979 ‘Equality of What?’ Tanner Lecture. Since then, the approach has gained a huge amount of attention as a conceptual framework which offers a clear and insightful way to measure well-being and development. Most recently, the approach has been refined and extended by Martha Nussbaum to issues of disability, nationality, and species membership in political philosophy. This project is about the foundations of the capability approach. More specifically, this project asks whether we can, and whether there are good reasons to, strengthen those foundations. The conclusions drawn here are that we ought to think seriously about the way that the capability approach develops as a theory that responds to real world challenges and change. More importantly, this project contends – in light of the challenges of future people and indigenous peoples – that there is good reason to think of new ways to ground the approach. This project takes up this challenge and grounds the approach in a modified version of Tim Mulgan’s approach to well-being. This project demonstrates that this alternative enriches the capability approach by providing us with a way of making sense of important problems, and with options for moving forward. Overall, this project asks important questions about how the capability approach could evolve based on challenges that remain relatively under-explored in the current literature. This project contributes to this literature by demonstrating that we can and ought to strengthen the capability approach and its ability to understand, take on board, and resolve these challenges.

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  • Houses and horror: a sociocultural study of Spanish and American women writers

    Pallejá-López, Clara (2010)

    Doctoral thesis
    The University of Auckland Library

    This thesis is a comparative study of haunted house fiction written by women in Spain and the United States from around 1900 onwards. It focuses on the aspect of sentience in buildings, establishing a connection between women's sociocultural history and transformations in the trope of the haunted house. This study highlights the vague presence of the haunted house in Spanish fiction when compared to American literature, and presents two reasons that might account for this circumstance. The first seems to be an overall discouragement of horror and fantasy in Spain that can be traced back at least to the times of the Spanish Empire. The second, which stands as the more important, is the particular situation of women in Spain, where a confluence of sociocultural factors upheld the values of domesticity for longer than in the United States, notably the repression enforced by the Franco dictatorship until 1975. I posit that the presence of the house in horror fiction grows in relation to women's envisioning of the home as the source of their oppression, and that this process is further nourished by underlying inherited anxieties resulting from women's legacy of domesticity. In particular, this study maintains that the sentient house is consolidated in literature the moment that women's primeval need for home enters into conflict with a rejection of domesticity. In order to illustrate this theory, I review work by American writers such as Charlotte Perkins Gilman, Elia W. Peattie, Shirley Jackson and Anne Rivers Siddons, and compare their narratives to those of Emilia Pardo Bazán, Carmen de Burgos, Mercè Rodoreda, Carmen Martín Gaite, Pilar Pedraza and Cristina Fernández Cubas in Spain. This thesis contends that Spanish horror literature presents belated but parallel transformations in the trope of the sentient house, which confirm the intertwining of this trope with women's culture across time and space.

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  • An investigation into how the cell cycle and the Notch signalling pathway regulate pronephrogenesis in Xenopus laevis

    Naylor, Richard (2009)

    Doctoral thesis
    The University of Auckland Library

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  • Alterations in cardiac contraction, intracellular calcium homeostasis amd cardiac remodelling in diabetic cardiomyopathy and the effect of triethylenetetramine treatment

    Zhang, Lin (2009-10)

    Doctoral thesis
    The University of Auckland Library

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  • Novel Linkers for Prostate Specific Pro-drug Systems

    Miller, Christian (2006)

    Doctoral thesis
    The University of Auckland Library

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  • Gene network inference and application

    Hurley, Daniel (2010)

    Doctoral thesis
    The University of Auckland Library

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  • Differentiating the afferent innervation of the mouse cochlea

    Barclay, Meagan (2010)

    Doctoral thesis
    The University of Auckland Library

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  • Making film-landscapes and exploring the geographical resonances of The Lord of the Rings and Whale Rider

    Le Heron, Erena (2008)

    Doctoral thesis
    The University of Auckland Library

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  • Development and Characterization of Biomaterials for Fistula Repair

    Keshaw, Hussila (2008)

    Doctoral thesis
    The University of Auckland Library

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  • Mechanisms of neurogenesis

    Park, In (2010)

    Doctoral thesis
    The University of Auckland Library

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  • From a hormone peptide to protein-receptor complexes; a structure and dynamics analysis by NMR

    Bobby, Romel (2013)

    Doctoral thesis
    The University of Auckland Library

    With the increasing number of protein related diseases, it is evident that a full comprehension of protein function with structural detail will facilitate rationales for a priori drug design. This research thesis used solution-state NMR spectroscopy to study the structure and dynamics of three proteins at the molecular level that are of therapeutic interest: (i) the human cytokine interleukin-6 (IL-6); (ii) the neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4-1) and (iii) the adrenomedullin receptor antagonist (AM22-52). IL-6 triggers Jak/Stat signaling pathways upon assembly with its cognate membrane bound alpha and beta receptors. Dysfunction of the signalling complex leads to crippling diseases. In the apo-form, dynamic analysis showed that IL-6 samples a vast range of conformations through inherrent motions. In particular, regions that are involved in beta receptor interactions were observed to show large amplitude motions, and may function to inhibit the direct interaction between IL-6 and the beta receptor. The results indicate that IL-6 exists in a dynamic state, whereby conformational selection and dynamic allostery play a role in complex assembly and, thus, in mediating cellular events. The determination of the three-dimensional structure of the Nedd4 WW3* in complex with the PY-motif of the epithelial Na+ channel revealed that binding follows the canonical PY-motif recognition paradigm forWWdomains. However, hitherto unknown side-chain interactions for WW - PY complexes were observed in the structure and, in conjunction with a dynamics analysis, revealed that the protein samples a broad range of conformational states on timescales between picoseconds to microseconds. In particular, conformational exchange processes for residues of theWWdomain located at the binding interface suggest that motions play a role in peptide recognition. Thus, both structural and dynamic features of the complex appear to define the high binding affinity. A chemical shift perturbation study conducted on the AM22-52 fragment in complex with the adrenomedullin receptor extracellular domain identified key residues in binding. Structural studies on the AM22-52 peptide showed that the peptide is essentially unstructured. This was supported by dynamic studies where residues involved in binding showed increased motions on the picosecond timescale. Altogether, these studies have relevance in the biomedical field and results obtained herein will contribute in the field of hypothesis-driven design of therapeutics.

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  • CI-921 : a clinical, pharmacokinetic and metabolic study of a potential new cytotoxic agent

    Hardy, Janet Rea (1989)

    Doctoral thesis
    The University of Auckland Library

    CI-921, an analogue of the antileukaemic agent amsacrine, was produced in an attempt to develop a cytotoxic agent with a broader spectrum of activity. CI-921 was selected for clinical trial on the basis of superior in vivo and in vitro solid tumour activity. Sixteen patients with histologically documented cancer for which there was no conventional cytotoxic treatment were entered into a phase I trial. The dose of CI-921 was escalated from 39mg/m2 to 810mg/m2 (total dose divided over 3 days) and repeated 3 weekly. Neutropenia was the major dose limiting toxicity and defined a maximum tolerated dose of 810 mg/m2. Pharmacokinetic studies revealed a biexponential pattern of drug distribution with a distribution half-life of 2.6 h. The kinetics appeared linear over the dose range tested. Less than 1% of total drug was excreted in the urine. Nineteen patients were entered into a limited phase II trial in non-small cell lung cancer using CI-921 at a dose of 648 mg/m2 in the same 3-day schedule. One of the 16 evaluable patients achieved a partial response lasting five months. Myelosuppression was the predominant toxicity as in the phase I trial, but the degree of toxicity confirmed this dose as being suitable for further phase II trials. One patient had a grand mal seizure temporally associated with three of four courses of CI-927 raising the possibility of neurotoxicity. Although drug-induced cardiotoxicity has been reported with the parent drug amsacrine, there was no evidence of this in the current study. It has been suggested that CI-921 undergoes hepatic metabolism and biliary excretion following conjugation with glutathione. There was no fall in whole blood glutathione levels in patients following CI-921 infusion, although a transient decrease in mouse hepatic GSH was demonstrated following both amsacrine and CI-921. The toxicity of CI-921 in mice was markedly increased following depletion of hepatic glutathione with BSO but was not affected by pre-treatment with morphine or the glutathione "protector" N-acetyl cysteine.

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  • Studies on the internal failure mechanics of lumbar intervertebral discs

    Veres, Samuel Peter (2009)

    Doctoral thesis
    The University of Auckland Library

    While several mechanical disruption studies of lumbar intervertebral discs have previously been carried out in vitro, none have sought to examine the microstructure of the resulting tissue failures. Consequently, how various spinal postures during loading and various loading rates for a given posture affect the disc's internal failure mechanics has yet to be documented. In the studies contained herein, ovine lumbar intervertebral discs have been mechanically disrupted by injecting radio-opaque gel into their nucleus via an injection screw inserted longitudinally through their inferior vertebra. The resulting disruption caused to each disc was subsequently examined using microcomputed tomography and microscopy in tandem.

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  • Mathematical modelling of energy demand and supply in the cardiac myocyte

    Tran, Kenneth (2010)

    Doctoral thesis
    The University of Auckland Library

    The mechanisms that regulate the control of energy demand and energy supply in the heart muscle are crucial for maintaining normal cardiac function, yet they are not very well understood. Although a number of mechanisms have been proffered by which mitochondrial supply of ATP can change to match varying workload in the myocardium, identifying the underlying regulatory pathways remains controversial. In this study, we have developed mathematical models of the sarcoplasmic endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump and the acto-myosin cross-bridge cycle which, along with the Na+/K+ pump, are the key energy-consuming processes in the cardiomyocyte. These models encapsulate both thermodynamic considerations and metabolite sensitivity into a cycle-based framework. The parameters of these models are constrained by experimental data which characterise their physiological behaviour. These models are then placed within the context of a whole-cell electrophysiological framework, alongside a model of mitochondrial energy supply, to investigate the mechanisms that regulate energy control and to shed light on two experimental observations which, for many decades, have evaded a mechanistic explanation: the apparent linearity of the VO₂- PVA (pressure-volume area) relationship and the metabolic stability hypothesis, wherein demand-supply homeostasis is maintained despite negligible variation in metabolite concentrations at varying workloads. The predictions from our model simulations indicate that, under constant metabolite concentrations, the ATP-FTI (force-time integral) relationship is linear, while the ATP- FLA (force-length-area, cellular equivalent of VO₂- PVA) relationship is linear only at low work rates. The linearity of the ATP-FTI relationship is found to arise from kinetic properties of the cross-bridge model. This property is not retained in the ATP-FLA relationship and is lost when metabolite concentrations are allowed to vary, as during normal variation with changing workload. This suggests that FTI and FLA are not equivalent, and that the VO₂- PVA relationship may only be approximately linear. Finally, we show that metabolite concentrations change significantly with increasing workload if Pi feedback onto mitochondrial oxidative phosphorylation is removed from the model, suggesting that Pi-regulation alone is sufficient to maintain metabolic homeostasis in the absence of other regulatory mechanisms.

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  • Affects : intermedial images between art, philosophy and science

    Sumich, Julainne S. (Julainne Sybil), 1941- (2006)

    Doctoral thesis
    The University of Auckland Library

    Four hyperlinks on page 2 of my dissertation do not work in pdf format. My dissertation investigates the correspondence and interaction between intermedial arts and thought processes. I devise a chemistry of affection to overcome the elusive synthesis between the arts and sciences; and through an appeal to neurological processes I attempt to make the event-related potential of the human mind visible,now, in its response to novelty.

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  • Logic and Landscapes: Simulating Surface Archaeological Record Formation in Western New South Wales, Australia

    Davies, Benjamin (2016)

    Doctoral thesis
    The University of Auckland Library

    Surface archaeological deposits are ubiquitous in arid Australia, but using them to reconstruct human behaviour and chronological sequences is made difficult by stratigraphic mixing. Contrasting interpretations of late Holocene human activity in the region have emerged, alternatively suggesting high levels of mobility and frequent hiatuses in occupation, or greater sedentism and population growth, based on equivocal archaeological patterning. The latter feature in narratives of socioeconomic intensification in Australian prehistory, prompting two questions that guide this thesis: is directional change needed to explain patterns in the surface record in western New South Wales and how can we know? Two simplified models of formation processes, formalised as agent-based simulations, are used to resolve differences in interpretations by evaluating their logic in an explicit framework and generating tests. The first, called HMODEL, is based on the concept of the archaeological palimpsest and demonstrates that infrequent, high intensity sedimentation events can generate patterning qualitatively similar to that explained elsewhere in behavioural terms. The second model, called FMODEL, features agents reducing stone and distributing it across a simulated space to examine the influence of movement patterns on the ratio of cortical to non-cortical stone (the Cortex Ratio) in flaked stone assemblages. Outcomes suggest that movement can influence the variability of ratio values, while systematic shifts depend on the consistent import or export of stone. Patterns observed in a large-scale surface survey at Rutherfords Creek, western New South Wales, are considered in light of simulation outcomes. Alternative models of hearth formation are compared to establish how each explains patterns in radiocarbon chronologies. Predictions from these models are tested against a second chronometric proxy, showing that patterning in the data is more aligned with geomorphological change operating on a consistent record of occupation than any detectable changes in population dynamics. The results of FMODEL further show that patterning in at Rutherfords Creek can be explained in large part by the relative abundances of raw material in the region. Both finds are consistent with a model of regularly occurring, short-term occupations over the course of the late Holocene. These demonstrate the potential for exploratory modelling of formation processes to resolve issues concerning contrasting interpretations of the past.

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  • Commuter’s journey to work travel behaviour and the aggregate road passenger travel demand in New Zealand

    Sheng, Mingyue (2016)

    Doctoral thesis
    The University of Auckland Library

    Economic development has historically been strongly associated with an increase in the demand for transportation and particularly in the number of road vehicles. However, traffic congestion, deterioration in air quality and climate change concerns also arise as a result of this escalation in road transport. Since New Zealand ratified the Kyoto Protocol in 1997, cutting down carbon dioxide equivalent (CO2-e) emissions has been a priority for contemporary government policy. Thus, reducing CO2-e emissions from road transport turns out to be critical because this sector alone accounts for 40% of all emissions in the country’s energy emission profile in 2012 (Ministry of Business, Innovation and Employment [MBIE], 2013). To date, local authorities and urban planners have shifted their interest to revitalising public transport as one practical approach of combating the negative externalities generated from road transport. Given that New Zealand, especially Auckland, has a relatively low level of public transport ridership compared to other Australasian cities, the understanding of which variables influence public transport demand at regional level, how travel decisions made by individual commuters, as well as what factors affect the demand for aggregate road passenger travel at national level become key questions to consider. This thesis contributes to the existing research on the analysis of commuter journey-to-work (JTW) behaviour in a spatial context at both the regional and the individual level. It also fills the research gap in the past literature by examining road passenger’s transport mode choices as a system of equations at the national level. Chapter 2 reviews the literature around traveller's travel behaviour and provides an overview of the methodology used in the following chapters. Using regional level JTW data, chapter 3 examines the relationship between urban form and public transport use in Auckland by applying a spatial Durbin model. Taking network effects into account, chapter 4 investigates individual commuter’s transport mode preferences in Auckland for their JTW travel by estimating a spatially autoregressive logit mode choice model. Chapter 5 develops an aggregate road passenger travel demand model using the seemingly unrelated regression (SUR) method, and the empirical results from the SUR model deliver some important policy implications in terms of achieving a reduction in the demand for both petrol and diesel cars, and also promoting the use of public transport. Chapter 6 concludes.

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  • Experimental analysis of navigation and homing in fluid environments

    Marcotte, Megan M. (2010)

    Doctoral thesis
    The University of Auckland Library

    How animals navigate over long distances is not understood despite decades of study. This thesis used lemon sharks as a new experimental model to study navigation because they home reliably after displacement and their responses to the Earth’s magnetic field could be compared with those of homing pigeons. I hypothesised that if movements by homing pigeons, aligned parallel and perpendicular to the intensity contours of the Earth’s magnetic field, are used in navigation, then other species of navigating animals should perform similar movements. Tracks of lemon sharks revealed movements similar to the magnetic alignments made by pigeons during homing. In sharks, this behaviour continued for much of the homeward journey, whereas in pigeons it occurs almost exclusively in the first few kilometres. The effects of magnets and the magnetic characteristics of release sites were examined with pigeons to explore how homing animals overcome magnetic disturbances while navigating over long distances. The magnets did not appear to affect the pigeons’ bearings and alignments, but the field angle variance and the difference between the aspect and home directions at the release sites were associated with the amount of disorientation displayed by the birds. This study was the first to use a multivariate analysis to examine the behaviour of homing pigeons and successfully distinguished magnetic field characteristics that vary at most release sites and that influence the birds’ behaviour from those that do not. This study identified similar responses to the Earth’s magnetic field in two vertebrate classes. The similarity of the behaviours was impressive considering the large differences between the animals, the speeds at which they move, and the fluid media in which they live. The behavioural similarities also suggest that the use of the magnetic field in long distance navigation may be common in vertebrates. The analysis of the effect of release site characteristics on the behaviour of navigating pigeons demonstrated the importance of a multivariate approach in navigational studies. Future research should expand this study with tracks from both pigeons and sharks, and may lead to a model of how navigating sharks and pigeons will react to magnetic fields upon displacement.

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  • Mechanics of sediment entrainment

    Dwivedi, Ambuj (2010)

    Doctoral thesis
    The University of Auckland Library

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