3 results for Aït-Khaled, N

  • Translation of questions: the International Study of Asthma and Allergies in Childhood (ISAAC) experience.

    Ellwood, Philippa; Williams, H; Aït-Khaled, N; Björkstén, B; Robertson, CF; and the ISAAC Phase Three Study Group; Asher, MI; Stewart, AW; Clayton, Tadd (2009-09)

    Journal article
    The University of Auckland Library

    OBJECTIVE: To explore the consequences of translating the International Study of Asthma and Allergies in Childhood (ISAAC) English core questionnaires on asthma, rhinitis and eczema symptoms into other languages. DESIGN: ISAAC Phase III developed 49 language translations for adolescents and 42 for children following standardised guidelines, which included back-translating the questionnaires into English to check their accuracy and meaning. Language deviations were categorised and analysed with regard to influences on the reported symptom prevalence. RESULTS: Category 1 deviations for one or more questions were found in seven translations (14%) for adolescents and in three translations (7%) for children. Data for these questions were excluded from the worldwide analyses. Category 2 deviations were identified in the publications, and Category 3 deviations were ignored. CONCLUSIONS: Translations of questionnaires should follow a consistent protocol in global epidemiological research. Cultural norms need to be considered when evaluating back-translations into English, as disease labels are not available in every language, nor are they understood in the same way. Deviations from literal translations of English should be permitted if the intent of the original meaning is retained. A web-based tool of medical terminology would be useful for international research requiring the use of translations.

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  • Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood Phase Three

    Aït-Khaled, N; Pearce, N; Anderson, HR; Ellwood, Philippa; Montefort, S; and the ISAAC Phase Three Study Group; Shah, J; Clayton, Tadd; Mitchell, Edwin; Stewart, AW; Asher, Monica Innes (2009)

    Journal article
    The University of Auckland Library

    Background: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global patterns of prevalence and severity of symptoms of rhinoconjunctivitis in children in 1993–1997. Methods: International Study of Asthma and Allergies in Childhood Phase Three was a cross-sectional survey performed 5–10 years after Phase One using the same methodology. Phase Three covered all of the major regions of the world and involved 1 059 053 children of 2 age groups from 236 centres in 98 countries. Results: The average overall prevalence of current rhinoconjunctivitis symptoms was 14.6% for the 13- to 14-year old children (range 1.0–45%). Variation in the prevalence of severe rhinoconjunctivitis symptoms was observed between centres (range 0.0–5.1%) and regions (range 0.4% in western Europe to 2.3% in Africa), with the highest prevalence being observed mainly in the centres from middle and low income countries, particularly in Africa and Latin America. Co-morbidity with asthma and eczema varied from 1.6% in the Indian sub-continent to 4.7% in North America. For 6- to 7-year old children, the average prevalence of rhinoconjunctivitis symptoms was 8.5%, and large variations in symptom prevalence were also observed between regions, countries and centres. Conclusions: Wide global variations exist in the prevalence of current rhinoconjunctivitis symptoms, being higher in high vs low income countries, but the prevalence of severe symptoms was greater in less affluent countries. Co-morbidity with asthma is high particularly in Africa, North America and Oceania. This global map of symptom prevalence is of clinical importance for health professionals.

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  • Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three

    Björkstén, B; Aït-Khaled, N; Asher, Monica Innes; Clayton, TO; Robertson, C; Anderson, HR; Beasley, R; Brunekreef, B; Crane, J; Flohr, C; Foliaki, S; Forastiere, F; García-Marcos, L; Keil, U; Lai, CKW; Mallol, J; Mitchell, EA; Odhiambo, J; Montefort, S; Pearce, N; Stewart, AW; Strachan, D; von Mutius, E; Weiland, SK; Williams, H; Wong, G; Howitt, ME; Weyler, J; de Freitas Souza, L; Rennie, D; Aguilar, P; Aristizábal, G; Cepeda, AM; Riikjärv, MA; sigmond, GZ; Awasthi, S; Bhave, S; Hanumante, NM; Jain, KC; Joshi, MK; Mantri, SN; Pherwani, AV; Rego, S; Salvi, S; Sharma, SK; Singh, V; Sukumaran, U; Suresh Babu, PS; Kartasasmita, CB; Masjedi, MR; Odajima, H; Imanalieva, C; Kudzyte, J; Quah, BS; Teh, KH; Baeza-Bacab, M; Barragán-Meijueiro, M; Del-Río-Navarro, BE; García-Almaráz, R; González-Díaz, SN; Linares-Zapién, FJ; Merida-Palacio, JV; Romero-Tapia, S; Romieu, I; MacKay, R; Moyes, C; Pattemore, P; Onadeko, BO; Cukier, G; Brêborowicz, A; Lis, G; Câmara, R; Lopes dos Santos, JM; Nunes, C; Rosado Pinto, JE; Lee, HB; Busquets, RM; Carvajal-Urueña, I; García-Hernández, G; González Díaz, C; López-Silvarrey Varela, A; Morales-Suárez-Varela, MM; Al-Rawas, O; Mohammad, S; Huang, JL; Kao, CC; Trakultivakorn, M; Vichyanond, P; Lapides, MC; Sears, M; Shah, J; Baratawidjaja, K; Lee, BW; Ellwood, Philippa (2011)

    Journal article
    The University of Auckland Library

    Background In Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), we investigated the relationship between breast feeding in infancy and symptoms of asthma, rhinoconjunctivitis and eczema in 6–7 year old children. Methods Parents or guardians of 6–7 year old children completed written questionnaires on current symptoms of asthma, rhinoconjunctivitis and eczema, and on a range of possible asthma risk factors including a history of breast feeding ever. Prevalence odds ratios were estimated using logistic regression, adjusted for gender, region of the world, language, per capita gross national income, and other risk factors.

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