2 results for Abrahams, BF

  • Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands.

    Carland, M; Abrahams, BF; Rede, T; Stephenson, J; Murray, V; Denny, William; McFadyen, WD (2006)

    Journal article
    The University of Auckland Library

    The complexes dichloro[2-(phenylselanyl)ethanamine]platinum(II), dichloro[2-(benzylselanyl)ethanamine]platinum(II) and dichloro(O-methylselenomethionine)platinum(II) have been prepared and the structure of dichloro(O-methylselenomethionine)platinum(II) has been determined by single crystal X-ray diffraction. The Pt(II) is in a square planar environment and is coordinated by two cis chloride ligands and a chelating O-methylselenomethionine ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and they are at least threefold less toxic than cisplatin in both cell lines.

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  • A 2D hydrogen-bonded network constructed from large organic dications

    Holmes, RJ; Abrahams, BF; Murray, V; Denny, William; McFadyen, WD (2010-06-30)

    Journal article
    The University of Auckland Library

    The crystal structure determination of N,N′-Bis-(2-aminoethyl)-phenazine-1,6-dicarboxamide dihydrochloride dihydrate reveals an essentially planar dication. A pair of ammonium groups tethered to the phenazine group in the 1 and 6 positions through alkyl amide links, act as hydrogen-bond donors to amide oxygen atoms of symmetry-related neighbouring dications. With each dication molecule having two hydrogen-bond donors and acceptors, an undulating 2D network is formed. The chloride ions, lying within the network voids, associate with the ammonium groups and pairs of water molecules. The network topology appears to be largely governed by cation–cation hydrogen-bonds, ionic associations involving the chloride ions and π–π-stacking interactions.

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