4 results for Atatoa Carr, PE

  • Growing Up in New Zealand: A longitudinal study of New Zealand children and their families. Report 1: Before we are born. Auckland: Growing Up in New Zealand.

    Morton, SMB; Atatoa Carr, PE; Bandara, DK; Grant, CC; Ivory, VC; Kingi, TR; Liang, R; Perese, LM; Peterson, E; Pryor, JE; Reese, E; Robinson, EM; Schmidt, JM; Waldie, KE (2010)

    Report
    The University of Auckland Library

    1.1 Background. Growing Up in New Zealand was set up in response to a recognised need by New Zealand policymakers for more robust, contemporary, population relevant evidence to inform their efforts to improve the quality of young New Zealander’s lives. The Ministry of Social Development has been the lead agency responsible for commissioning and funding this study, with support from multiple other agencies including Ministries of Health, Education, Justice, and Research, Science and Technology as well as Statistics New Zealand, the Families Commission, Ministry of Pacific Island Affairs, Department of Labour, New Zealand Police, SPARC (Sport and Recreation New Zealand) and Te Puni Kokiri. The design and processes for this study were subject to an extensive, peer-reviewed development phase between 2005 and 2007. After agreement that the proposed design would meet the required objectives, the longitudinal study proper was launched as Growing Up in New Zealand in April 2008.

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  • Growing Up in New Zealand: A longitudinal study of New Zealand children and their families: Report 1: Before we are born.

    Morton, Susan; Atatoa Carr, PE; Bandara, DK; Grant, Cameron; Ivory, VC; Kingi, TR; Liang, R; Perese, LM; Peterson, Elizabeth; Pryor, JE; Reese, E; Robinson, EM; Schmidt, Johanna; Waldie, Karen (2010)

    Report
    The University of Auckland Library

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  • Too many left at risk by current folic acid supplementation use in New Zealand

    Morton, Susan; Grant, Cameron; Atatoa Carr, PE (2013-04)

    Journal article
    The University of Auckland Library

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  • Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever

    Raynes, JM; Frost, HRC; Williamson, DA; Young, Paul; Baker, Edward; Steemson, JD; Hughes, Jacelyn; Proft, Thomas; Dunbar, Peter; Atatoa Carr, PE; Bell, A; Moreland, Nicole (2016-07)

    Journal article
    The University of Auckland Library

    Acute rheumatic fever (ARF) is an autoimmune response to Group A Streptococcus (GAS) infection. Repeated GAS exposures are proposed to ‘prime’ the immune system for autoimmunity. This notion of immune-priming by multiple GAS infections was first postulated in the 1960s, but direct experimental evidence to support the hypothesis has been lacking. Here, we present novel methodology, based on antibody responses to GAS T-antigens, that enables previous GAS exposures to be mapped in patient sera. T-antigens are surface expressed, type specific antigens and GAS strains fall into 18 major clades or T-types. A panel of recombinant T-antigens was generated and immunoassays were performed in parallel with serum depletion experiments allowing type-specific T-antigen antibodies to be distinguished from cross-reactive antibodies. At least two distinct GAS exposures were detected in each of the ARF sera tested. Furthermore, no two sera had the same T-antigen reactivity profile suggesting that each patient was exposed to a unique series of GAS T-types prior to developing ARF. The methods have provided much-needed experimental evidence to substantiate the immune-priming hypothesis, and will facilitate further serological profiling studies that explore the multifaceted interactions between GAS and the host.

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