7 results for Rewcastle, Gordon, Patent

  • Pteridinones as kinase inhibitors

    Denny, William; Rewcastle, Gordon; Dobrusin, EM; Kramer, JB; McNamara, DJ; Showalter, HD; Toogood, PL (2007)

    Patent
    The University of Auckland Library

    View record details
  • 5-Substituted-4-[(substituted phenyl)amino]-2-pyridone derivatives

    Black, Shannon; Kaufman, MD; Ortwine, DF; Plummer, MS; Quin, J; Rewcastle, Gordon; Shahripour, AB; Spicer, Julie; Whitehead, CE (2007)

    Patent
    The University of Auckland Library

    The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

    View record details
  • Substituted pyrimidines and triazines and their use in cancer therapy

    Rewcastle, Gordon; Shepherd, Peter; Chaussade, C; Denny, William; Gamage, Swarnalatha (2009)

    Patent
    The University of Auckland Library

    Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110α isoform of PI3K.

    View record details
  • Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer Therapy

    Rewcastle, Gordon; Gamage, Swarnalatha; Flanagan, JU; Giddens, Anna; Tsang, KY (2013-06-11)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g. compounds of Formula 1A, 1B, and 1C, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

    View record details
  • Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy

    Rewcastle, Gordon; Tsang, KY; Gamage, Swarnalatha; Giddens, Anna (2013-07-16)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

    View record details
  • Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy

    Rewcastle, Gordon; Gamage, Swarnalatha; Flanagan, JU; Giddens, Anna; Tsang, KY (2014-07-08)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

    View record details
  • 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

    Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

    Patent
    The University of Auckland Library

    The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

    View record details