83 results for Conference poster, 2000

  • What Does My Grade Mean?: Differing Assessment Models in Chemistry.

    Salter, David (2009-06)

    Conference poster
    The University of Auckland Library

    Determining whether students have learnt what was intended is a crucial aspect of every course. How this is done and what the outcome shows can however vary greatly. Traditionally in New Zealand, tertiary students’ academic ability is assessed using methods that allow for discrimination between students through norm-referencing, typically producing a single cumulative percentage value which is translated into a letter grade. In contrast, the Government-mandated system for assessing secondary school students in New Zealand is based on a model of criterion-referenced assessment that aims to describe students’ current level of performance with reference to specific performance criteria which are derived from national curriculum statements. Consequently, in progressing from secondary to tertiary education in New Zealand, students experience a major change in the assessment of their performance from being independent of others to being relative to others. A comparison of these two assessment systems used in New Zealand will be presented as well as a description of how standards-based assessment is being introduced into several first-year tertiary chemistry courses as a way to better indicate students’ current capabilities and assist students in the transition between secondary and tertiary education.

    View record details
  • Functional analysis of the novel melanoma master-regulators

    Wang, Li (2008)

    Conference poster
    The University of Auckland Library

    Melanoma is a devastating form of cancer that is especially common in New Zealand and that is incompletely understood. In this project, we are using clinical microarray information about the function of tens of thousands of genes in melanoma patients. We are combining this clinical microarray information with microarray analysis of melanoma cells in the laboratory. In this laboratory analysis we have knocked down the expression of 75 different genes using a method known as siRNA. This clinical and laboratory data is combined mathematically using a method known as gene network analysis. This allows us to identify novel "master-regulators" of melanoma, which are seen as “hubs” in melanoma gene networks. These hubs may drive the uncontrolled growth of melanoma cells, and are likely to be useful as prognostic markers or new drug targets. We have already identified several novel melanoma gene network hubs using this method. The sequences encoding these hubs are cloning into an expression vector, and the candidate hub genes are then screened through a functional screening platform. Since we are interested the clinically important genes, we screen to identify those genes that may play a role in proliferation, sensitivity to drug-induced apoptosis, and survival. We will transfect all the candidate genes (alongside a negative vector only control and a positive control of Bcl-2) into 293T cells (human embryonic kidney cells containing the SV40large T antigen to promote episomal replication of transfected plasmids), and A375 cells (melanoma). We will screen for expressed gene function using assays for viable cell number (MTT), assays for cell cycle progression (flow cytometry), and apoptosis assays. In particular we will use the anti-neoplastic drug etoposide (VP16) to induce apoptosis in cells that have been transfected by these genes and controls, to assess gene product function in modifying the apoptosis induced by VP16. For clinically relevant network hub genes that appear to play a role in controlling proliferation, apoptosis and survival, we will home in further on their mechanism of action (the methods used will depend upon our hypotheses about the gene product's function). We hope some of those hubs may lead to novel diagnostic/prognostic assays and novel drug targets.

    View record details
  • What drives bacterial community structure in stream biofilms?

    Roberts, Kelly; Lear, Gavin; Turner, Susan; Lewis, Gillian (2008-08-17)

    Conference poster
    The University of Auckland Library

    BACKGROUND The microorganisms within biofilms are the key basal trophic level within most freshwater systems. However, microbial structure, function and succession in natural stream systems remain poorly understood. This research characterises the biofilm community structure of stream biofilms experiencing different anthropogenic impacts and how they change over time. Our aim is describe the changes in bacterial biofilm communities over time and to investigate what drives these changes.

    View record details
  • CellML: Cellml.org, Tools and Community

    Lawson J.; Lloyd C.; Noble P.; Hunter P.; Nielsen P. (2007)

    Conference poster
    The University of Auckland Library

    Poster presented at ICSB2007 The purpose of CellML is to store and exchange computer-based mathematical models of as wide a range of scale and subject as posssible. For example, biochemical signalling and metabolic systems can be embedded in electrophysiological models of excitable cells in CellML. The CellML language is an open standard based on the XML markup language and is being developed by the Bioengineering Institute at the University of Auckland and affiliated research groups [1]. The majority of computational biology publications aim to discuss their model but often fail to provide a comprehensive set of instructions for recreating the model, or include errors preventing reproduction of published model outputs. Publishing a paper with a link to a CellML model facilitates the wide distribution and recreation of that model, and additionally forces the modeller to carefully consider matters such as unit consistency. The CellML specification and application programming interfaces (API) are driven by a core team, but a growing international community is involved in work related to CellML. A community website (www.cellml.org) has been set up as a focal point for the community and also functions as a model repository. A number of groups are developing software tools for CellML and using the language for research in computational biology. A repository of almost 300 unique CellML models is available at www.cellml.org/models: these are computational models from peer-reviewed publications that have been coded into CellML. These models are undergoing an active curation process based on the MIRIAM standard, proposed by the international biological modelling community [2]. This process includes provision of comprehensive documentation, annotation with citation and model author metadata, maintenance of file modification histories, and correspondence with model authors to ensure that models define all required initial conditions and parameters. The CellML community strongly supports collaboration with other groups to continue to set standards for curation and distribution of biological models. A number of free / open source software tools for developing and simulating CellML models are available, including Physiome CellML Environment (PCEnv) and Cellular Open Resource (COR). Other modelling environments such as JSim and Virtual Cell also support the CellML format. Information on further tools such as validators, debuggers and simulation specific packages can be found at www.cellml.org/tools. In the near future, models in the cellml.org model repository will be completely annotated with ontologies such as BioPaX and references to databases such as UniProt. Models will be broken down into the components from which they are comprised, and these components will themselves be curated, providing a toolbox of standardised computational parts from which new models can be created, in an in silico analogy to the MIT Registry of Standard Biological parts (http://parts.mit.edu/registry/index.php/Main_Page). An API has recently been developed for software tools to allow interaction between CellML and SVG diagrams of models, such as biochemical pathway schematics, and work is also underway to standardise graphical representations of CellML models. For more information, please join the CellML community mailing list at http://www.cellml.org/mailman/listinfo/cellml-discussion. 1.) Cuellar, A.A., Lloyd, C. M., Nielsen, P. F., Bullivant, D. P., Nickerson, D. P., Hunter, P. J. "An Overview of CellML 1.1, a Biological Model Description Language" Simulation, 2003, 79, No. 12, 740-747 2.) Le Novere, N., Finney, A., Hucka, M., Bhalla, U.S., Campagne, F., Collado-Vides, J., Crampin, E.J., Halstead, M., Klipp, E., Mendes, P., Nielsen, P., Sauro, H., Shapiro, B., Snoep, J.L., Spence, H.D., Wanner, B.L. "Minium information requested in the annotation of biochemical models (MIRIAM)" Nature Biotechnology, 2005, 23 1509-1515

    View record details
  • Can tree weta detect terrestrial bats

    Lomas, Kathryn; Field, LH; Wild, John; Kubke, Maria; Parsons, Stuart (2008-10)

    Conference poster
    The University of Auckland Library

    Interactions between insects and bats are well-known examples of predator-prey co-evolution. For example, moths have evolved hearing abilities that allow them to respond to sounds in the ultrasound range, thus enabling them to detect the echolocation calls of hunting bats and perform evasive manoeuvres (Roeder 1998). Although New Zealand insects are preyed upon by endemic bats, no studies have examined whether they possess similar strategies for predator avoidance. If auditory information is used to detect and avoid predation, then the frequencies of greatest sensitivity of the auditory organ are predicted to correspond to the echolocation frequency (or other hunting-related sounds) produced by predatory bats. New Zealand has two endemic bats, the long tailed bat (Chalinolobus tuberculatus) and lesser short tailed bat (Mystacina tuberculata). Long tailed bats are typical aerial insectivores and are not known to prey on weta.

    View record details
  • Practice-led curricula: driving from the front or rear seat?

    Adamson, Carole (2009-11-11)

    Conference poster
    The University of Auckland Library

    Do knowledge-driven or practice-led models best serve the needs of social work practitioners engagin

    View record details
  • Using neuroanatomical imaging to learn about New Zealand's endemic species

    Corfield, Jeremy; Wild, John; Parsons, Stuart; Kubke, Maria (2009-08)

    Conference poster
    The University of Auckland Library

    Isolated from the world, New Zealand became a place where birds, in the absence of terrestrial mammals, evolved a diverse assortment of shapes, sizes and behaviours.

    View record details
  • Modelling NFAT Cycling Sensitivity in the Cardiac Myocyte

    Cooling, Michael; Hunter, Peter; Crampin, Edmund (2007-10-01)

    Conference poster
    The University of Auckland Library

    The transcription factor NFAT acts as a signal integrator for a number of signal transduction pathways in cardiac myocytes that initiates gene expression in the disease Pathological Cardiac Hypertrophy[1]. Here we develop a quantitative mathematical model of the cytoplasmicnuclear-cytoplasmic cycling of NFAT in response to calcium signals in the cardiac myocyte

    View record details
  • Stream Restoration: Getting the microbial ecology right.

    Lewis, Gillian; Lear, Gavin; Turner, Susan; Boothroyd, Ian; Stott, Rebecca; Roberts, Kelly; Ancion, Pierre; Dopheide, Andrew; Washington, Vidya; Knight, Duane; Smith, Joanna (2008-08-17)

    Conference poster
    The University of Auckland Library

    A comprehensive program to re-establish the structure and function of an ecosystem, including its natural diversity and aquatic habitats.

    View record details
  • Bacterially mediated manganese deposition in novel "anelli" within the biofilms of an impacted urban stream

    Smith, JP; Lewis, Gillian (2007-12-02)

    Conference poster
    The University of Auckland Library

    The purpose of this work is to identify bacteria responsible for the formation of manganese containing anelli within stream biofilms, and study their distribution. Manganese oxidising bacteria are part of a diverse group of organisms found commonly within many disparate environments, which deposit manganese and iron biominerals within biofilms and flocs [1]. The purpose of microbial manganese oxidation is poorly understood, but may be associated with energy production, mobilisation of nutrients, protection and/or detoxification [1, 2]. Manganese has a high sorptive capacity for heavy metals, metalloids, and other ions, as well as a strong oxidizing potential, and therefore frequently induces co-precipitation of cations present within the surrounding environment [1]. Within urban streams contaminants such as heavy metals may therefore potentially be concentrated within steam biofilms in the presence of manganese oxidising bacteria.

    View record details
  • A novel implantable blood pressure telemetry device: Comparison between Data Sciences and Telemetry Research systems

    Malpas, Simon; Lim, M; McCormick, John; Kirton, RS; Van Vliet, B; Easteal, Allan; Barrett, Carolyn; Guild, Sarah-Jane; Budgett, David (2008-04-05)

    Conference poster
    The University of Auckland Library

    The pending expiry (May 2008) of a Data Sciences (DSI) patent in the area of blood pressure telemetry permits the development of alternative technologies. A key aspect in providing new telemetry systems is a comparison to existing technology. Important aspects include stability of the calibration over time and the ability to capture the pulsitile blood pressure waveform. In a group of 6 rats and 5 rabbits DSI blood pressure transmitters (C40 or D70 models) were implanted in conjunction with Telemetry Research (TR) transmitters. Both systems incorporate a fluid filled catheter of similar dimensions with a biocompatible gel in the tip. The blood pressure waveform was collected via telemetry for up to 2 months after implantation. The signal was sampled at 500 Hz and digitally transmitted to a receiver up to 5 m away The battery of TR transmitter was recharged within the rat using inductive power transfer technology. The pulsitile waveform associated with each heart beat was reflected similarly in all cases although the frequency response of DSI telemeters was limited to ~40 Hz (–3 dB rolloff point). The calibrated offset level between the two transmitters was not more than 5 mmHg at all times over a 2 month period. We conclude that the Telemetry Research blood pressure transmitters offer comparable performance to existing technology but with extra design advantages (rechargeable, co-housing of animals, greater range).

    View record details
  • Metabolomics as a novel approach to study mixed species biofilms of stream bacteria exhibiting mutualistic and antagonistic responses

    Washington, Vidya; Villas-Boas, Silas; Lewis, Gillian (2008-08-17)

    Conference poster
    The University of Auckland Library

    Experimental objective / Purpose 1. To investigate the metabolic interactions of bacterial species using metabolic footprint profiling. 2. As proof of concept, microbes exhibiting mutualistic and antagonistic associations were chosen for this study.

    View record details
  • Molecular investigation of protozoan diversity in stream biofilms

    Dopheide, AJ; Lear, Gavin; Lewis, Gillian (2006-11-21)

    Conference poster
    The University of Auckland Library

    This research aims to test the following hypothesis: that molecular biological methods will allow description of protozoan diversity and ecology in streams.

    View record details
  • A Multiscale, Spatially-Distributed Model of Airway Hyper-Responsiveness

    Donovan, Graham; Politi, Antonio; Sneyd, A; Tawhai, Merryn (2009-05)

    Conference poster
    The University of Auckland Library

    Rationale: Airway hyper−responsiveness (AHR), along with airway hyper−sensitivity, is a defining feature of asthma, and greater understanding of this emergent phenomenon may lead to better insight into and treatment of the condition. We seek a multiscale, spatially−distributed, mathematical model of the lung to help us understand the role of airway smooth muscle and parenchymal material in AHR. Methods: Our model couples together the organ scale with the tissue scale in the lung in a multiscale approach to the problem. At the organ level, parenchymal tissue is modeled as a compressible Blatz−Ko material in three dimensions, with expansion and recoil of lung tissue due to tidal breathing. The governing equations of finite elasticity deformation are solved using a finite element method. An airway tree is embedded in this tissue, with airway smooth muscle behavior described by a modified Hai−Murphy cross−bridge model (Wang et al., Biophys. J. 94:2008). Each airway segment is initially assumed to be radially symmetric and longitudinally stiff, and thus the embedded airway tree is essentially 1D. Results: Our spatially−distributed, multiscale model yields organ−level observations while incorporating tissue−level modeling detail. Preliminary results from the integrated model indicate potential use in the study of many phenomena associated with asthmatic AHR, including spatial distribution of ventilation defects, patchiness, and effects of deep inspirations.

    View record details
  • New sugar agents for the control of undesirable microbes in the food industry

    Oliveira, Maria; Justino, J; Neves, A; Rauter, AP (2007-11-14)

    Conference poster
    The University of Auckland Library

    View record details
  • Cell proliferative and radioprotective properties of bioactive Salvia sclareoides extracts

    Ruivo, D; Oliveira, Maria; Rauter, AP; Justino, J; Goulart, M (2008-11)

    Conference poster
    The University of Auckland Library

    View record details
  • Characterisation of the Genetic and Hormone controls of Branching in Petunia

    Simons, Joanne; Templeton, K; Plummer, K; Beveridge, C; Snowden, K (2004-09)

    Conference poster
    The University of Auckland Library

    View record details
  • Effects of Storm water metal contaminats on microbial communities in stream biofilm revealed by Automated Ribosomal Intergenic Spacer Analysis (ARISA)

    Ancion, Pierre; Lear, Gavin; Lewis, Gillian (2008-08-17)

    Conference poster
    The University of Auckland Library

    Stormwater metal contaminants are known to be a threat to our freshwater environments but little is known about their effects on stream micro-organisms. This project investigates accumulation and release of the most common stormwater metal contaminants (zinc, copper and lead) in stream biofilms and their effects on bacterial populations.

    View record details
  • Afferent axonal pathfinding in developing chicken rhomboencephalon

    Kubke, Maria; Wild, JM (2008)

    Conference poster
    The University of Auckland Library

    The developing hindbrain of vertebrates i organized in a series of rhombomeres, each giving rise to specifi c nuclei. The role of this segmentation has been extensively studied with respect to the origin of motor nuclei. The development of afferent innervation, however, has received little attention. Afferent axons enter the brainstem prior to the migration of their central targets and must therefore navigate in the absence of target derived information. Since the target nuclei for each afferent component originates within discrete rhombomeric boundaries, it is possible that the same positional information that is used by neuronal progenitors to defi ne their fi nal fate, may be available to afferent axons to direct them through their initial growth. This study was aimed at determining the normal sequence that characterises the growth of afferent axons in the hindbrain within the context of the site of origin and of the organisation of second order sensory neurons within specifi c rhombomere boundaries. Afferent axons were labelled at different embryonic ages using fl uorescent lipophilic dyes. Crystals of DiI and/or DiO were placed on specifi c exposed nerves or nerve branches of fi xed embryos. Embryos were incubated at 30 C for 18 hrs, after which the hindbrains were dissected, cleared in glycerol and analysed as whole-mount preparations with confocal microscopy. Afferent axons formed a series of fascicles that extended longitudinally along the alar plate, beyond the rhombomeric boundaries that give rise to their target nuclei. At early stages, the degree of organization and segregation of afferent axons did not appear to refl ect the adult patterns. Thus, it appears that the appropriate pathfi nding and fi nal segregation of the afferent components involves an initial profuse growth into the hindbrain, and that proper afferent patterning involves axon retraction and may require the initiation of migration if the central targets towards their fi nal position.

    View record details
  • Institutional Collaboration around Institutional Repositories

    Hayes, Leonie; Stevenson, Alison; Mason, Ingrid; Scott, Anne; Kennedy, Peter (2007)

    Conference poster
    The University of Auckland Library

    Three New Zealand universities have been collaborating on a project to provide open, web-based, access to research outputs through the creation of institutional repositories using the DSpace software. This poster will therefore address the theme of eResearch with particular focus on the benefits of active collaboration, intra-university, inter-university and international, in this area of activity. New Zealand has a small population of 4 million, an innovative and resourceful academic community, a newly implemented research funding model, based on performance (PBRF) and a readiness to stay competitive with the rest of the world. Institutional Repositories in New Zealand are in their infancy but a considerable body of experience already exists overseas which we can draw upon if we work in partnership with those institutions who have already implemented institutional repositories. Funding is limited but by sharing resources and working collaboratively each institution can make substantial progress towards the creation of individual repositories. This poster reports on the joint project between the University of Auckland, the University of Canterbury and Victoria University of Wellington. The three partners have been funded by the New Zealand Tertiary Education Commission to make available, via the Internet for access by Open Archives Initiative (OAI) compliant search engines, research outputs created by staff and students of the three partner institutions. This poster will present information on the work to: • Establish DSpace repositories in partner institutions that conform to the OAI-PMH standard. • Contribute to the development of linkages with the Australian DEST funded information infrastructure projects, i.e. ADT, APSR and ARROW projects. • Identify methods for increasing academic understanding of, and promoting contributions to, digital repositories the content of which is then available to enhance teaching and learning, as well as research. • Provide digital materials, either through the deposit of “born digital” material or through digitisation of material already available in print, that contribute to the developing digital content landscape as envisaged in the NZ Digital Strategy • Contribute to national research resource discovery service to be established by the National Library of New Zealand. Ensure that the content in the project repositories is visible for harvesting by global OAI-compliant search engines such as Google Scholar, OAIster, etc. Collaborate with other IR projects and communicate the lessons learned to the wider tertiary and research communities of New Zealand

    View record details