27 results for Conference poster, 2015

  • Can we minimize androgen deprivation therapy-related quality of life effects in Māori & Pacific prostate cancer survivors using a genetic stratification?

    Karunasinghe, N; Zhu, Y; Han, Dug; Lange, K; Wang, A; Zhu, Shuotun; Masters, J; Goudie, M; Keogh, J; Benjamin, B; Holmes, M; Ferguson, Lynnette (2015-11-15)

    Conference poster
    The University of Auckland Library

    BACKGROUND: Androgen deprivation therapy (ADT) is an effective palliation treatment for men with advanced prostate cancer (PC). This is a common treatment received by the majority of PC survivors among New Zealand (NZ) Maori men due to their late presentation of the disease. However, ADT have well documented side effects that could alter the patient’s quality of life (QoL). ADT involves suppression of androgens produced either by the testes or the adrenal gland or both. Adrenal androgen production involves conversion of androstenedione to testosterone by the aldo-keto reductase 1C3 (AKR1C3) enzyme. We have previously reported that the AKR1C3 rs12529 G allele is associated with a lower prostate specific antigen (PSA) level, which is a downstream product of androgens binding to the androgen receptor. The AKR1C3 rs12529 G allele frequency is 14.2% higher among Māori, Pacific and East Asian men compared to Caucasians in our study cohort. Therefore, the current assessment is to evaluate whether genetic stratification with the AKR1C3 rs12529 polymorphism could support decision making on ADT to minimize QoL effects. METHODS: A patient cohort with confirmed clinical diagnoses of PC was recruited with written consent from 2006-2014 to Urology studies carried out at the Auckland Cancer Society Research Centre, University of Auckland, NZ. Recruitment was carried out at hospitals managed under three District Health Boards of Auckland, and private Urology clinics from Waikato District, in NZ. From May 2013, patients were invited to complete a questionnaire that contained options for selecting PC treatment type/s received and a QoL survey. The primary outcomes were the percentage scores under each QoL subscale assessed using the European Organisation for Research and Treatment of Cancer quality of life questionnaires (EORTC QLQ-C30 and PR25). Genotyping of these men for the AKR1C3 rs12529 single nucleotide polymorphism (SNP) was carried out using the Sequenom MassArray and iPlex system or the Applied Biosystem’s Taqman SNP genotyping procedure. Age at diagnosis, Gleason score and alcohol consumption were confounding variables between ADT and no ADT groups, and were corrected for subsequent analysis. Analysis of QoL scores were carried out against ADT duration or in association with the AKR1C3 rs12529 SNP using the Generalised Linear Model. P-values <0.02]. This increase among the rs12529 GG genotype (9.7) is therefore, equivalent to 59% of the mean hormone treatment-related symptom score of 16.5 (SD16.6) recorded in this study. INTERPRETATION: As 85.3% ADT recipients have used AA the current study is best interpreted as QoL effects of AAs. This study suggests a possibility for those stratified with the AKR1C3 rs12529 G allele to receive intermittent AA treatment to minimize QoL effects. If larger prospective studies can confirm these findings, PC survivors particularly those of Maori and Pacific ethnic groups may greatly benefit through optimal ADT options not only for their survival benefits, but also to better maintain their QoL.

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  • Mid-term results after phaco-canaloplasty and canaloplasty

    Hurtikova, KH; Traine, PT; Loertscher, Martin; Mueller, MM (2015-06-06)

    Conference poster
    The University of Auckland Library

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  • Preclinical rationale for the ongoing Phase 2 study of the hypoxia-activated EGFR-TKI tarloxotinib bromide (TH-4000) in patients with advanced squamous cell carcinoma of the head and neck (SCCHN) or skin (SCCS).

    Jackson, V; Silva, S; Abbattista, Maria; Guise, Christopher; Bull, Matthew; Ashoorzadeh, Amir; Hart, C; Pearce, T; Smaill, Jeffrey; Patterson, Adam (2015)

    Conference poster
    The University of Auckland Library

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  • Who are Today's Dads?

    Underwood, Lisa; Atatoa Carr, P; Berry, S; Grant, Cameron; Morton, Susan (2015-12-14)

    Conference poster
    The University of Auckland Library

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  • Cardiac response to weak electrical shocks challenges the functional syncytium paradigm

    Caldwell, Bryan; Trew, Mark; Pertsov, AM (2015-04-11)

    Conference poster
    The University of Auckland Library

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  • Annotation of Clinical Datasets Using openEHR Archetypes

    Zivaljevic, Aleksandar; Atalag, Koray; de Bono, B; Hunter, Peter (2015-02-19)

    Conference poster
    The University of Auckland Library

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  • Quality of Life in Fit Elderly Patients with Chronic Lymphocytic Leukemia (CLL) Receiving Oral Fludarabine-Based Regimens As First Line Therapy: Australasian Leukaemia and Lymphoma Group (ALLG) CLL5 Trial

    Suneet, S; Gill, D; Turner, PD; Renwick, WEP; Latimer, M; Mackinlay, N; Berkahn, Leanne; Simpson, DR; Campbell, P; Forsyth, C; Cull, G; Harrup, R; Best, G; Bressel, M; Di Iulio, J; Kuss, BJ; Mulligan, S (2015-12-03)

    Conference poster
    The University of Auckland Library

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  • In Vitro Immunogenicity Screening of Two Novel Bone Graft Scaffolds

    Lock, Alistair; Gao, Yang; Callon, Karen; Pool, B; Choi, A; Munro, Jacob; Cornish, Jillian; Musson, David (2015-11-03)

    Conference poster
    The University of Auckland Library

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  • Gorgeous Gallery: residential aged care in New Zealand, in pictures

    Broad, Joanna (2015)

    Conference poster
    The University of Auckland Library

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  • Where's the Sablefish?: Exploring causes of variable sablefish (Anoplopoma fimbria) representation in Northwest Coast sites

    Nims, Reno; Butler, V (2015-03)

    Conference poster
    The University of Auckland Library

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  • Population Pharmacokinetics of Ethanol in Moderate and Heavy Drinkers

    Jiang, Y; Holford, Nicholas; Murry, DJ; Brown, TL; Milavetz, G (2015-10-07)

    Conference poster
    The University of Auckland Library

    Objectives: To investigate the effect of sex, age, and previous drinking history on ethanol pharmacokinetic parameters with the implementation of a rate dependent extraction model [1], which takes into account the change in hepatic first-pass extraction along with absorption rate and a body composition model that accounts for fat free mass and fat mass [2]. Methods: 108 moderate or heavy drinkers were dosed orally on 2 occasions to achieve a peak blood ethanol concentration of 0.65 g/L or 1.15 g/L using a randomized, crossover design. A total of 6025 breath measurements were obtained and converted into blood alcohol concentration by applying a blood: breath ratio of 2100:1. NONMEM 7.3.0 was used for data analysis. A semi-mechanistic rate dependent extraction model with zero-order input followed by first order absorption was utilized with V allometrically scaled by normal fat mass, Vmax allometrically scaled by total body weight and portal vein blood flow allometrically scaled by fat free mass. The effects of sex and age (21–34, 38–51, or 55–68 years of age) on V, Vmax, and Km; and the effect of drinking status (moderate or heavy drinkers) on Vmax and Km were explored. The covariate effect was considered to be statistically significant if the 95 % non-parametric bootstrap confidence interval of the fractional difference did not include 1. Results: The 95 % bootstrap confidence interval of fractional differences between groups in age, sex and ethanol consumption history all contain 1, indicating none of those covariates have significant effects on any ethanol disposition parameters. Conclusions: Age and sex were not regarded as significant predictors for ethanol disposition parameters after accounting for body size and composition. The results indicated a 19 % higher Vmax and 15 % lower Km for heavy drinkers compared with moderate drinkers, but the difference was not statistically significant.

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  • Retrospective case-series from a Myopia Control Clinic

    Turnbull, Philip; Phillips, John (2015-10-09)

    Conference poster
    The University of Auckland Library

    Background: The prevalence of myopia continues to grow, and there are now a number of optical treatment options available to clinicians. However real world clinical data on their effectiveness is sparse. To promote anti-myopia treatments, a specialist Myopia Control Clinic (MCC) opened as a referral clinic at The University of Auckland, New Zealand in 2010, and this is the first comprehensive audit of the clinical outcomes. Case Series: We present a retrospective case series of 110 patients (aged 4 – 33 years, mean: 12.13 ± 4.58 years, 57% female) who attended the MCC between 2010 and 2014. Of these, 56 underwent orthokeratology (OK), 32 wore dual focus soft contact lenses (DFCL), and 22 received advice only. Baseline myopia, vitreous and axial eye length, previous myopia progression, age, number of myopic parents, and gender were not different between OK and DFCL groups at baseline. However, the advice group were older (p = 0.037) and had less previous myopic progression (p = 0.001). Mean follow-up time was 1.30 ± 0.88 and 1.33 ± 0.80 years in OK and SCL groups respectively (p = 0.989). There was a significant reduction in the annualised myopia progression in both treatment groups (OK: -1.17 ± 0.55 to -0.09 ± 017D/yr, p < 0.001, DFCL: -1.15 ± 0.46 to -0.10 ± 0.23D/yr, p < 0.001). There was no difference between OK and DFCL treatment efficacy (p = 0.763), nor in axial or vitreous chamber length changes following treatment (p = 0.184). Only one adverse event was reported over the 4 year period. Conclusions: Contact lenses, whether OK or DFCL, are an effective strategy for targeting myopia progression in children. As there was no difference in the efficacy of the two methods, there are very few barriers in terms of upskilling, chair time, or capital expenditure, for any practitioner to be actively promoting myopia control treatments to at risk groups.

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  • Impact of conjugate pneumococcal vaccine on nasopharyngeal S.pneumoniae serotypes and antibiotic susceptibility over 7 years

    Best, Emma; Taylor, S; Tse, F; McBride, C; Stewart, Joanna; Lennon, Diana; Trenholme, A (2015-03-19)

    Conference poster
    The University of Auckland Library

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  • A case of overwhelming sepsis in splenectomised child

    Alkhudairi, Z; Wilson, E; Best, Emma (2015-03-19)

    Conference poster
    The University of Auckland Library

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  • Apple Waste Preservation for Extraction of Antioxidants

    Zhan, D; Oliveira, Maria; Saleh, Z (2015-11)

    Conference poster
    The University of Auckland Library

    A huge amount of apple waste is generated from juice, cider and other apple product industries. This waste represents a cost and causes environmental problems. Apple waste is a rich source of polyphenolic compounds, mostly found in the apple peels and cores. Polyphenols are antioxidants with high value that can be extracted from the waste and exploited commercially. Proper methods of waste pasteurisation would allow its preservation and reduce waste degradation. In this study, diluted apple waste was pasteurised using three different technologies: thermal processing (TP), high pressure processing (HPP) and low pressure assisted thermal processing. The effect of processing on the waste native yeasts and moulds, inoculated Saccharomyces cerevisiae yeast and antioxidants were investigated. TP at 60, 80 and 100 °C for 30 min, HPP at 300, 400 and 500 MPa for 10 min and 600 MPa for 20 min, and low pressure assisted thermal processing at 60, 80 and 100 °C with 2 MPa for 30 min were carried out. The total yeasts and moulds initially in the diluted apple waste was about 6.6×101 cfu/g, which was fully inactivated by the three technologies. S. cerevisiae inoculated in the waste was reduced by 5-log or more with all processing methods/conditions. HPP and low pressure assisted thermal processing treatments did not affect the antioxidant activity (DPPH-radical scavenging). However, both TPC and DPPH radical scavenging decreased with TP (p < 0.05). The results of this study can be helpful for designing appropriate conditions to pasteurise fruit industry byproducts for further extraction of high value antioxidants.

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  • Do you see what I see? - Surveillance and response

    Patel, Reena; Dixon, Robyn; Webster, Craig (2015-07-06)

    Conference poster
    The University of Auckland Library

    Introduction: Early warning scoring systems and rapid response teams are important strategies to improve the detection of patient deterioration in hospitals. Initiation of an appropriate response relies on nurses recognising changes in patient condition and alerting the required emergency assistance team. Study Objective: To determine the level of concordance between the nurse’s assessment and that of the emergency team, based on early warning scores (EWS). Methods: An audit of data collected between June 2011 and May 2013 was undertaken and 2780 instances were reviewed in order to determine the degree of concordance on EWS scores between nurses initiating calls and those assigned by the emergency response team. Results: 881 instances lack of concordance was identified. In the majority of instances, the nurse overestimated the severity of the patient’s condition when compared to the emergency response team’s score. Conclusion: Such lack of concordance is problematic given that failure to activate an emergency response when required has obvious implications for patient safety while inappropriate referral to emergency response teams can result in inefficient use of resources.

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  • Variability in soil CO2 efflux across distinct urban land cover types

    Weissert, Lena; Salmond, Jennifer; Schwendenmann, Luitgard (2015-04-14)

    Conference poster
    The University of Auckland Library

    As a main source of greenhouse gases urban areas play an important role in the global carbon cycle. To assess the potential role of urban vegetation in mitigating carbon emissions we need information on the magnitude of biogenic CO2 emissions and its driving factors. We examined how urban land use types (urban forest, parklands, sportsfields) vary in their soil CO2 efflux.We measured soil CO2 efflux and its isotopic signature, soil temperature and soil moisture over a complete growing season in Auckland, New Zealand. Soil physical and chemical properties and vegetation characteristics were also measured. Mean soil CO2 efflux ranged from 4.15 to 12 molm 2 s 1.We did not find significant differences in soil CO2 efflux among land cover types due to high spatial variability in soil CO2 efflux among plots. Soil (soil carbon and nitrogen density, texture, soil carbon:nitrogen ratio) and vegetation characteristics (basal area, litter carbon density, grass biomass) were not significantly correlated with soil CO2 efflux. We found a distinct seasonal pattern with significantly higher soil CO2 efflux in autumn (Apr/May) and spring (Oct). In urban forests and sportsfields over 80% of the temporal variation was explained by soil temperature and soil water content. The 13C signature of CO2 respired from parklands and sportsfields (-20 permil - -25 permil) were more positive compared to forest plots (-29 permil) indicating that parkland and sportsfields had a considerable proportion of C4 grasses. Despite the large intra-urban variability, our results compare to values reported from other, often climatically different cities, supporting the hypothesis of homogenization across urban areas as a result of human management practices.

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  • Moving From Hard Copy to Online Marking Made Easy

    Li, C; Sheridan, Donald (2015-06)

    Conference poster
    The University of Auckland Library

    Significant efficiencies can be made in marking classes with large enrolment using a workflow that involves existing or inexpensive technologies. This poster describes how innovative processes saved time, money, improved educational outcomes and quality assurance.

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  • Investigation into the racemic X-ray structure of the antimicrobial protein snakin-1

    Yeung, Ho; Yosaatmadja, Yuliana; Squire, Christopher; Harris, Paul; Baker, Edward; Brimble, Margaret (2015-08-31)

    Conference poster
    The University of Auckland Library

    Snakin-1 is a 63 residue antimicrobial protein originally isolated from potato (Solanum tuberosum).1 It is active against a number of bacterial and fungal phytopathogens such as Clavibacter michiganensis, Pseudomonas syringae and Fusarium solani. Snakin-1 is a member of the GASA (gibberellic acid stimulated in Arabidopsis)/snakin family and the mature protein consists of a GASA domain incorporating six intramolecular disulfide bonds.2 The amino acid sequences of these proteins do not correspond to any known structural motifs. GASA/snakin proteins are found in a variety of plant species and appear to be involved in a range of functions including cell elongation and cell division.2 Their expression profiles support these roles and are commonly linked to development.2 It has also been speculated that the 12 conserved cysteines in these proteins perform a role in redox regulation.2 We have recently completed the total chemical synthesis of native Snakin-1 and showed that its antimicrobial activity is comparable to that of the naturally occurring protein.3 In an attempt to understand how this small protein functions we have determined its threedimensional structure by X-ray crystallography using a quasi-racemic protein system.4 Phase information for structural determination was obtained by radiation-damage induced phasing.5 The structure of snakin-1 appears to be novel, different to known classes of cysteine-rich plant antimicrobial peptide. Its features include a large and distinctly electropositive loop that we speculate to be membrane targeting, and a two helix bundle which is a potential membrane-interacting feature able to disrupt the structural integrity of its target bacteria.

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  • Reverse Mentoring: Benefits and Barriers

    Ross, M; Dunham, Annette (2015)

    Conference poster
    The University of Auckland Library

    Background: Current research suggests that the modern workforce is comprised of a substantial proportion of ageing employees, in addition to an influx of young, first-time workers. This diverse and multigenerational workforce provides organisations an interesting challenge, in retaining engaged and productive employees, and ensuring relevant training and development. One specific management practice is reverse mentoring. Reverse mentoring is a unique form of mentoring, whereby the traditional roles of mentor and mentee are reversed. It involves a junior employee (in age/status) mentoring a senior employee. The junior employee is able to share their recent generational learnings and perspective with a senior organisational member, who gains insight into recent trends and technologies. Whilst there appear to be many benefits from this relationship, including increased communication and understanding; leadership development; and upskilling in relevant trends, there may also be some barriers to the success of the relationship. Barriers may include a resistance to the shift in power hierarchy and challenges with changing the traditional learning pedagogy of older teacher and younger learner. Aim: Reverse mentoring is a reasonably modern concept, and as such, empirical research on this practice is relatively new. This research aims to explore any benefits and barriers experienced in a reverse mentoring relationship. Method: Participants in this study will be recruited from a Melbourne hospital, who currently run a formal reverse mentoring relationship program. Approximately 16 individuals (8 mentors and 8 mentees), will be invited to participate. The proposed study uses a qualitative method of data collection, through semi-structured interviews. Interviews will be recorded, and responses will be transcribed, with thematic analysis used to identify common themes. Thematic analysis allows the common themes and experiences of mentors and mentees, to tell an overall story of the data. Conclusion: The proposed study’s findings contribute to a currently small base of research on reverse mentoring. It is hoped that the research will help (i) inform future quantitative research on reverse mentoring and (ii) inform organisational strategies that will help employees engage in reverse mentoring relationships in ways that effectively support their training and development.

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