63 results for Patent

  • Compressor Improvements

    McGill, IC; Boyd, JR; White, DJ; Patel, U; Bruce, CS; Read, TG; Otte, G; Bonniface, BR; Mallinson, Gordon (2008)

    Patent
    The University of Auckland Library

    Compressor having a single cylinder (15012) with an enclosed end defining a compression space, with a piston (15002,15004) reciprocating in said single cylinder, comprising: a plurality of gas flow paths (15008) from said compression space to a discharge space, a self operating valve (15020;17008) in each said gases flow path, opening under the influence of the prevailing pressure differential across the valve, and being biased to a closed condition by a spring (17006), each said valve and spring being part of a single unitary planar valve member (15020;17002).

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  • Methods of increasing radiosensitivity using inhibitors of trefoil factor 1 (TFF1)

    Lobie, Peter; Perry, Johanna (2012)

    Patent
    The University of Auckland Library

    The invention relates generally to the use of inhibitors of TTF1 to increase radiosensitivity of tumors and other cells. The invention provides methods of inhibiting proliferation or survival of a tumor cell; methods of treating, delaying the progression of, preventing a relapse of, or alleviating a symptom of a cancer or other neoplastic condition; methods increasing sensitivity of a tumor cell to radiotherapy; methods of enhancing or supplementing an anti-cancer therapy in a subject that is receiving or has been administered radiotherapy; and methods of inhibiting one or more activity or function of a TFF1 - stimulated cancer stem cell.

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  • Cognitive Enhancement and Cognitive Therapy Using Glycyl-L-2-Methylprolyl-L-Glutamic Acid

    Gluckman, Peter; Guan, Jian; Woodworth, M; Brimble, Margaret

    Patent
    The University of Auckland Library

    This invention provides compounds, compositions and methods for treating loss of cognitive function in animals that results from aging. In particular, compounds of this invention can stimulate neural cell growth, increased amounts of cells containing a key enzyme needed for production of the cholinergic neurotransmitter, and can improve memory and cognitive function in animals who have experienced a loss of memory or cognitive function as a result of aging.

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  • Conducting polymer nanowire brain-machine interface systems and methods

    Llinas, RR; Hunter, IW; Ruddy, Bryan (2013-03-26)

    Patent
    The University of Auckland Library

    The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

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  • Jet injector use in oral evaluation

    Hunter, IW; Chen, Y; Hogan, NC; Ruddy, BP (2012)

    Patent
    The University of Auckland Library

    A tooth treatment device includes a detector that detects a marker of oral health and a fluid ejector that ejects fluid against teeth in response to the detected marker. The device can include a housing configured to be held on hand, the fluid ejector being positioned at an end of the housing. The fluid may include a liquid, a medicant, a cleansing solution, cleaning particles, or any combination thereof. The medicant can include any combination of a chelating agent, fluoride, a fluorescent dye, a bacterial specific probe, and a biochemical specific biomarker. Further, the device can include a servo controller controlling pressure of ejected fluid in response to the detected marker and a sensed surface condition, latter including for example, a mechanical property of tissue. The device may include a pressure sensor that senses pressure of the fluid in the ejector. Also included may be a distance sensor that senses distance of the ejector from a tissue surface. The surface condition may be sensed using the sensed pressure, sensed distance, or any combination thereof. In some embodiments, the fluid ejector comprises a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. A method of tooth treatment includes detecting a marker of oral health and controlling ejection of a fluid jet against the tooth responsive to the detected marker. In some embodiments, detecting the marker includes detecting plaque and the ejection is controlled to clean the plaque. Detecting the marker can include collecting a sample from an oral cavity.

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  • 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

    Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

    Patent
    The University of Auckland Library

    The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

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  • 1,2,4-benzotriazine-1,4-dioxides

    Denny, William; Hay, Michael; Hicks, Kevin; Pruijn, Frederik; Wilson, William; Pchalek, Karin (2010)

    Patent
    The University of Auckland Library

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  • Transcription Factors

    Bloksberg, LN; Bryant, C; Connett, MB; Emerson, SJ; Frost, MJ; Forster, RLS; Grigor, M; Higgins, C; Lasham, Annette; Lund, ST; Magusin, A; Phillips, J; Puthigae, S; Veerakone, S; Westwood, C; Gause, K; Wood, M; Havukkala, I; Rottmann, WH (2009-03-24)

    Patent
    The University of Auckland Library

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  • Pteridinones as kinase inhibitors

    Denny, William; Rewcastle, Gordon; Dobrusin, EM; Kramer, JB; McNamara, DJ; Showalter, HD; Toogood, PL (2007)

    Patent
    The University of Auckland Library

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  • Directly photodefinable polymer compositions and methods thereof

    Elce, E; Bell, A; Knapp, B; Ng, H; Rhodes, LF; Shick, R; Zhang, W; Dimenna, W; Jayaraman, S; Jin, Jianyong; Puthenkovilakom, RR; Ravikiran, R; Wu, X; Takeuchi, E (2011)

    Patent
    The University of Auckland Library

    A polymer includes a first type of repeat unit represented by Formula I, where X is selected from -CH2-, -CH2-CH2-, or -O-; m is an integer from 0 to about 5; and where for the first type of repeat unit one of R1, R2, R3, and R4 is one of a maleimide containing group and for the second type of repeat unit one of R1, R2, R3, and R4 is a hindered aromatic group, a C8 or greater alkyl group, a C4 or greater halohydrocarbyl or perhalocarbyl group, a C7 or greater aralkyl group, or a heteroatom hydrocarbyl or halohydrocarbyl group.

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  • Improvements for Cochlear Implants

    Bradley, AP; Petoe, Matthew; Wilson, WJ (2010)

    Patent
    The University of Auckland Library

    The invention relates to a method of generating a place-frequency map for accurate positioning of a cochlear implant whereby the place-frequency map is used to relate a physical position of the cochlear implant to a tonotopic map of the basilar membrane/spiral ganglion. The invention also relates to a method of electrically positioning of an already inserted cochlear implant within the cochlea to provide stimuli to only the parts of the cochlea that have reduced or no residual hearing.

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  • Pyrazolo[1,5-a]pyridines and their use in cancer therapy

    Kendall, JD; Marshall, Andrew (2009)

    Patent
    The University of Auckland Library

    Phosphoinositide-3-kinases (PI3Ks) are a group of lipid kinases which phosphorylate the 10 3-hydroxyl of phosphoinositides. They are split into three classes (Class I, II and Ill) and play an important role in cellular signalling [Stephens et al., Curr. Opin. Pharmacal. 2005, 5, 357]. The Class I enzymes are further split into Class Ia and lb based on their mechanism of activation; the Class Ia PI3Ks are heterodimeric structures consisting of a catalytic subunit (p11 Oa, p11 013 or p11 0~) in complex with a regulatory p85 subunit, while 15 the class-IB PI3K (p11 Oy) is structurally similar but lacks a reguiatory subunit linking and instead is activated by 13v subunits of heterotrimeric G-proteins [Walker et al,. Moi.Ce/1., 2000, 6, 909]. PI3Ks play a variety of roles in normal tissue physiology [Foukas & Shepherd, Biochem. 20 Soc. Trans., 2004,32, 330; Shepherd,Acta Physiol. Scand,. 2005, 183, 3], with p110a having a specific role in cancer growth, p11 013 in thrombus formation mediated by integrin aul33 [Jackson et al., Nat. Med., 2005, 11, 507], and p11 Oy in inflammation, rheumatoid arthritis [Camps et al., Nat. Med., 2005, 11, 936] and other chronic inflammation states [Barber et al., Nat. Med., 2005, 11, 933]. The PI3K enzymes produce phosphoinositide 25 3,4,5-triphosphate (PIP3) from the corresponding diphosphate (PIP2), thus recruiting AKT (protein kinase B) through its PH domain, to the plasma membrane. Once bound, AKT is phosphorylated and activated by other membrane bound kinases, and is central to a cascade of events that lead to inhibition of apoptosis [Berrie, Exp. Opin. Invest. Drugs, 2001, 10, 1085].

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  • Embryo modification and implantation.

    Blake, Deborah; Carter, NL; Henry, SM (2010-10-26)

    Patent
    The University of Auckland Library

    The present invention relates to constructs and methods used to enhance the attachment and implantation of an embryo. It is shown that modified glycolipids and glycolipid-attachment molecule constructs can be used to modify embryos, or localised to target tissues, to enhance interaction between the embryo and the target tissue, (typically the endometrium). The invention may advantageously be used to enhance implantation of embryos in the uterus, for example, in IVF treatments.

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  • System and method for mapping gastro-intestinal electrical activity.

    O'Grady, Gregory; Cheng, LK; Pullan, AJ; Du, P; Erickson, JC (2011)

    Patent
    The University of Auckland Library

    A gastro-electrical activity mapping system and comprises a catheter insertable through a natural orifice into the gastro-intestinal (GI) tract and comprising an array of electrodes for contacting an interior surface of a section of the GI tract to detect electrical potentials at multiple electrodes, and a signal analysis and mapping system arranged to receive and process electrical signals from multiple electrodes of the array and spatially map GI smooth muscle electrical activity as an activation time map, a velocity map, or an amplitude map, which may be in the form of contour plots and may be mapped on an anatomical computer model of at least the section of the GI tract and may be animated. A GI mapping method and catheter are also claimed.

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  • Contact lens and method for prevention of myopia progression

    Phillips, John (2011)

    Patent
    The University of Auckland Library

    A method of slowing the progression of myopia in a person, comprises applying to the eye of the person contact lens or lenses each including a vision correction area for correcting in use the myopic vision of a wearer, and a myopic defocus area having a less negative focal power, to simultaneously present a controlled myopic defocus to the retina both when viewing in the distance and also when viewing at near. Contact lenses and their use are also claimed.

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  • Methods and compositions for increasing storage-life of fruit

    Atkinson, R; Schaffer, Robert; Gunaseelan, K; Schroeder, R (2010)

    Patent
    The University of Auckland Library

    The invention provides methods and compositions for producing plants with fruit having increased post-harvest storage life, the method comprising reducing the expression or activity in the plant, of a polypeptide with the amino acid sequence of SEQ ID NO: 1(Malus domestica polygalaturonase, MdPG1), or a variant of the polypeptide. The invention provides host cells, plant cells and plants transformed with the polynucleotides of the invention. The invention also provides methods for selecting plants with fruit having increased postharvest storage life. The invention also provides plants produced and selected by the methods of the invention.

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  • Conducting polymer nanowire brain-machine interface systems and methods

    Llinas, RR; Hunter, IW; Ruddy, Bryan (2010-10-19)

    Patent
    The University of Auckland Library

    The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

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  • Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer Therapy

    Rewcastle, Gordon; Gamage, Swarnalatha; Flanagan, JU; Giddens, Anna; Tsang, KY (2013-06-11)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g. compounds of Formula 1A, 1B, and 1C, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

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  • Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy

    Rewcastle, Gordon; Tsang, KY; Gamage, Swarnalatha; Giddens, Anna (2013-07-16)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

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  • Conformable antenna using conducting polymers

    Ruddy, BP; Hunter, IW; Montemayor, L; Paster, ET; Pillai, P

    Patent
    The University of Auckland Library

    Antenna including a wire made of a conducting polymer. The wire is sewn into fabric material in a selected pattern. A preferred conducing polymer is polypyrrole. It is also preferred that the Wire be encased in a non-conductive, low dielectric plastic.

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