63 results for Patent

  • Conducting polymer nanowire brain-machine interface systems and methods

    Llinas, RR; Hunter, IW; Ruddy, Bryan (2013-03-26)

    Patent
    The University of Auckland Library

    The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

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  • Heat Exchanger

    Taylor, MP; Chen, John; Farid, M; Wallace, RJ (2014-07-15)

    Patent
    The University of Auckland Library

    A heat exchanger 10 includes a conduit 12 for conveying cooling fluid relative to a body to be cooled. A heat transfer arrangement 62 is arranged in communication with an interior of the conduit 12, the heat transfer arrangement 62 and the conduit 12 together defining an assembly that is mountable adjacent the body to be cooled, convective heat exchange occurring, in use, due to movement of the cooling fluid relative to the body and to the heat transfer arrangement 62 of the assembly and radiant heat exchange occurring between the body and at least part of the heat transfer arrangement 62 of the assembly.

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  • 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

    Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

    Patent
    The University of Auckland Library

    The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

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  • Jet injector use in oral evaluation

    Hunter, IW; Chen, Y; Hogan, NC; Ruddy, BP (2012)

    Patent
    The University of Auckland Library

    A tooth treatment device includes a detector that detects a marker of oral health and a fluid ejector that ejects fluid against teeth in response to the detected marker. The device can include a housing configured to be held on hand, the fluid ejector being positioned at an end of the housing. The fluid may include a liquid, a medicant, a cleansing solution, cleaning particles, or any combination thereof. The medicant can include any combination of a chelating agent, fluoride, a fluorescent dye, a bacterial specific probe, and a biochemical specific biomarker. Further, the device can include a servo controller controlling pressure of ejected fluid in response to the detected marker and a sensed surface condition, latter including for example, a mechanical property of tissue. The device may include a pressure sensor that senses pressure of the fluid in the ejector. Also included may be a distance sensor that senses distance of the ejector from a tissue surface. The surface condition may be sensed using the sensed pressure, sensed distance, or any combination thereof. In some embodiments, the fluid ejector comprises a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. A method of tooth treatment includes detecting a marker of oral health and controlling ejection of a fluid jet against the tooth responsive to the detected marker. In some embodiments, detecting the marker includes detecting plaque and the ejection is controlled to clean the plaque. Detecting the marker can include collecting a sample from an oral cavity.

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  • Inductively Powered Mobile Sensor System

    Malpas, Simon; Hu, AP; Budgett, David (2004-09-16)

    Patent
    The University of Auckland Library

    The present invention provides an inductively powered sensor system having a primary conductive path capable of being energized to provide an electromagnetic field in a defined space. An inductive power pick-up is associated with a sensor and is capable of receiving power from the field to supply the sensor. The system includes a first sensing unit to sense the power available to the pick-up and a control unit to increase or decrease the power available to the sensor dependant on the sensed power available. A method of inductively powering a sensor, an inductively powered sensor and an animal enclosure including one or more primary conductive path of an inductive power supply are also disclosed.

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  • Compositions and Methods for Regulating Plant Gene Expression

    Espley,, RV; Hellens,, RP; Allan,, AC; Chagné,, D (2008)

    Patent
    The University of Auckland Library

    The invention provides a method for producing a chimeric promoter polynucleotide capable of controlling transcription of an operably linked polynucleotide in a plant cell or plant, wherein the method comprises combining: a) at least one sequence motif comprising a sequence with at least 70% identity to SEQ ID NO:1, 11 or 12, and b) another polynucleotide sequence. The invention also provides chimeric promoters polynucleotides comprising the sequences defined in a) and b). The invention also provides constructs, vectors, host cells, plant cells and plants comprising the chimeric promoter polynucleotides of the invention. The invention also provided methods for modifying gene expression and phenotype of plant cells and plants by transforming the plant cells and plants with the chimeric promoter polynucleotides of the invention.

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  • Transcription factors

    Bloksberg, LN; Bryant, C; Connett, MB; Emerson, SJ; Forster, RLS; Frost, J; Gause, K; Grigor, M; Havukkala, I; Higgins, C; Lasham, Annette; Lund, ST; Magusin, A; Phillips, J; Puthigae, S; Rottmann, WH; Veerakone, S; Westwood, C; Wood, M (2012)

    Patent
    The University of Auckland Library

    The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided. Products and methods of use are disclosed.

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  • Cascaded Raman Laser

    Martinelli, C; Leplingard, F; Sylvestre, T; Vanholsbeeck, Frederique; Emplit, P (2006-02-07)

    Patent
    The University of Auckland Library

    A cascaded Raman laser (10) has a pump radiation source (12) emitting at a pump wavelength λp, an input section (14) and an output section (16) made of an optical medium. Each section (14, 16) comprises wavelength selectors (141, 142, . . . , 145 and 161, 162, . . . , 165) for wavelengths λ1, λ2, . . . , λn−k, where n≧3, λp< . . . <λn and λn−k+1, λn−k+2, . . . , λn being k≧1 emitting wavelengths of the laser (10). The laser further comprises an intracavity section (18) that is made of a non-linear optical medium, has a zero-dispersion wavelength λ0 and is disposed between the input (14) and the output (16) section. The wavelengths λ1, λ2, . . . , λn−k of the wavelength selectors (141, 142, . . . , 145 and 161, 162, . . . , 165) and the zero-dispersion wavelength λ0 of the intracavity section (18) are chosen such that energy is transferred between different wavelengths by multi-wave mixing.

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  • Kinase inhibitors, prodrug forms thereof and their use in therapy.

    Smaill,, JB; Patterson, AV; Lu, G-L; Lee, Ho; Ashoorzadeh, A; Anderson, RF; Wilson, WR; Denny, WA; Hsu, A; Maroz, A; Jamieson, SMF; Mowday, AM; Carlin, KM (2011-03-10)

    Patent
    The University of Auckland Library

    The present invention relates to pyrido[3,4-d]pyrimidine compounds of formula (I) suitable as kinase inhibitors, kinase inhibitors in prodrug form, their use in compositions and medicaments which are suitable for the treatment of diseases related to kinase activity such as cancers.

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  • Oral formulations of Glycyl-2-Methylprolyl-Glutamate.

    Wen, Jingyuan; Thomas, G; Bickerdike, MJ (2009)

    Patent
    The University of Auckland Library

    Oral formulations of G-2MePE including microemulsions, coarse emulsions, liquid crystals, tablets and encapsulated forms of G-2MePE have improved bioavailability than conventional aqueous formulations. In particular, microparticles, nanoparticles and microemulsions can exhibit great neuroprotective effects after oral administration. In a microemulsion formulation, G-2MePE can nearly completely inhibit cerebral infarction in an animal model of stroke even after the stroke had been initiated. Thus, improved oral formulations can be desirably used to treat a variety of neurodegenerative conditions with improved convenience and improved efficacy.

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  • Marker assisted selection of a mammalian subject for desired phenotype

    Davis, S; Lehnert, K; Berry, SDK; Snell, Russell; Beattie, EM (2011)

    Patent
    The University of Auckland Library

    The present invention provides methods of genotyping mammalian subjects for desired lactoferrin phenotypes by determining the lactoferrin genotype of the subject. The invention particularly provides methods wherein the presence or absence of the T allele or the C allele at the 30126 T/C polymorphism, of the A allele or the G allele at the 7447 A/G polymorphism, or of the C allele or the G allele at the -7 G/C polymorphism in the bovine Lf gene, is associated with increased or decreased lactoferrin production or secretion, including increased or decreased milk or colostrum Lf content.

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  • Dielectric elastomer self-sensing using plane approximation

    O'Brien, BM; Gisby, TA; Anderson, IA (2011)

    Patent
    The University of Auckland Library

    The present invention provides a method for obtaining feedback parameters related to the state of a dielectric elastomer (DE). The method comprises introducing a small-scale oscillation to the voltage difference between electrodes of the DE, monitoring or repeatedly measuring several measurable electrical characteristics of the DE, deriving other relevant data from the measurements, deriving an equation for a plane of best fit through the relevant data when defined as orthogonal axes, and deriving the feedback parameters from coefficients of the plane equation. The method thus provides important feedback regarding the capacitance, leakage current and/or electrode resistance of the DE. Also disclosed are a computer program and a system adapted to perform the method.

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  • System and method for tracking facial muscle and eye motion for computer graphics animation

    Sagar, Mark; Scott, R (2009)

    Patent
    The University of Auckland Library

    A motion tracking system enables faithful capture of subtle facial and eye motion using a surface electromyography (EMG) detection method to detect muscle movements and an electrooculogram (EOG) detection method to detect eye movements. An embodiment of the motion tracking animation system comprises a plurality of pairs of EOG electrodes adapted to be affixed to the skin surface of the performer at locations adjacent to the performer's eyes. The EOG data comprises electrical signals corresponding to eye movements of a performer during a performance. Programming instructions further provide processing of the EOG data and mapping of processed EOG data onto an animated character. As a result, the animated character will exhibit he same muscle and eye movements as the performer.

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  • Adrenocorticotropic hormone analogs and related methods

    Brennan, MB; Costa, Jessica; Dores, RM; Hochgeschwender, U; Haskell-Luevano, C (2007)

    Patent
    The University of Auckland Library

    ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.

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  • Murine endometriosis modelled by K-ras activation of menstruating endometrium

    Charnock-Jones, D; Print, Cristin; Cheng, C (2009)

    Patent
    The University of Auckland Library

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  • Conducting polymer nanowire brain-machine interface systems and methods

    Llinas, RR; Hunter, IW; Ruddy, BP (2011)

    Patent
    The University of Auckland Library

    The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

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  • Directly photodefinable polymer compositions and methods thereof

    Elce, E; Bell, A; Knapp, B; Ng, H; Rhodes, LF; Shick, R; Zhang, W; Dimenna, W; Jayaraman, S; Jin, Jianyong; Puthenkovilakom, RR; Ravikiran, R; Wu, X; Takeuchi, E (2011)

    Patent
    The University of Auckland Library

    A polymer includes a first type of repeat unit represented by Formula I, where X is selected from -CH2-, -CH2-CH2-, or -O-; m is an integer from 0 to about 5; and where for the first type of repeat unit one of R1, R2, R3, and R4 is one of a maleimide containing group and for the second type of repeat unit one of R1, R2, R3, and R4 is a hindered aromatic group, a C8 or greater alkyl group, a C4 or greater halohydrocarbyl or perhalocarbyl group, a C7 or greater aralkyl group, or a heteroatom hydrocarbyl or halohydrocarbyl group.

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  • Improvements for Cochlear Implants

    Bradley, AP; Petoe, Matthew; Wilson, WJ (2010)

    Patent
    The University of Auckland Library

    The invention relates to a method of generating a place-frequency map for accurate positioning of a cochlear implant whereby the place-frequency map is used to relate a physical position of the cochlear implant to a tonotopic map of the basilar membrane/spiral ganglion. The invention also relates to a method of electrically positioning of an already inserted cochlear implant within the cochlea to provide stimuli to only the parts of the cochlea that have reduced or no residual hearing.

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  • 5-Substituted-4-[(substituted phenyl)amino]-2-pyridone derivatives

    Black, Shannon; Kaufman, MD; Ortwine, DF; Plummer, MS; Quin, J; Rewcastle, Gordon; Shahripour, AB; Spicer, Julie; Whitehead, CE (2007)

    Patent
    The University of Auckland Library

    The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

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  • Substituted pyrimidines and triazines and their use in cancer therapy

    Rewcastle, Gordon; Shepherd, Peter; Chaussade, C; Denny, William; Gamage, Swarnalatha (2009)

    Patent
    The University of Auckland Library

    Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110α isoform of PI3K.

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