155 results for The University of Auckland Library, Harding, Jane

  • Multi-nutrient fortification of human milk for preterm infants

    Brown, JVE; Embleton, ND; Harding, Jane; McGuire, W (2016)

    Journal article
    The University of Auckland Library

    Exclusively breast milk-fed preterm infants may accumulate nutrient deficits leading to extrauterine growth restriction. Feeding preterm infants with multi-nutrient fortified human breast milk rather than unfortified breast milk may increase nutrient accretion and growth rates and may improve neurodevelopmental outcomes. Objectives To determine whether multi-nutrient fortified human breast milk improves important outcomes (including growth and development) over unfortified breast milk for preterm infants without increasing the risk of adverse effects (such as feed intolerance and necrotising enterocolitis). Search methods We used the standard search strategy of the Cochrane Neonatal Review Group. This included electronic searches of the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 2), MEDLINE, EMBASE and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (until February 2016), as well as conference proceedings and previous reviews. Selection criteria Randomised and quasi-randomised controlled trials that compared feeding preterm infants with multi-nutrient (protein and energy plus minerals, vitamins or other nutrients) fortified human breast milk versus unfortified (no added protein or energy) breast milk. Data collection and analysis We extracted data using the standard methods of the Cochrane Neonatal Review Group. We separately evaluated trial quality, data extracted by two review authors and data synthesised using risk ratios (RRs), risk differences and mean differences (MDs). We assessed the quality of evidence at the outcome level using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Main results We identified 14 trials in which a total of 1071 infants participated. The trials were generally small and weak methodologically. Meta-analyses provided low-quality evidence that multi-nutrient fortification of breast milk increases in-hospital rates of growth (MD 1.81 g/kg/d, 95% confidence interval (CI) 1.23 to 2.40); length (MD 0.12 cm/wk, 95% CI 0.07 to 0.17); and head circumference (MD 0.08 cm/wk, 95% CI 0.04 to 0.12). Only very limited data are available for growth and developmental outcomes assessed beyond infancy, and these show no effects of fortification. The data did not indicate other potential benefits or harms and provided low-quality evidence that fortification does not increase the risk of necrotising enterocolitis in preterm infants (typical RR 1.57, 95% CI 0.76 to 3.23; 11 studies, 882 infants). Authors' conclusions Limited available data do not provide strong evidence that feeding preterm infants with multi-nutrient fortified breast milk compared with unfortified breast milk affects important outcomes, except that it leads to slightly increased in-hospital growth rates.

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  • Global Motion Perception in 2-Year-Old Children: A Method for Psychophysical Assessment and Relationships With Clinical Measures of Visual Function

    Yu, Tzu-Ying; Jacobs, Robert; Anstice, Nicola; Paudel, Nabin; Harding, Jane; Thompson, Benjamin; CHYLD Study Team (2013-12)

    Journal article
    The University of Auckland Library

    Purpose. We developed and validated a technique for measuring global motion perception in 2-year-old children, and assessed the relationship between global motion perception and other measures of visual function. Methods. Random dot kinematogram (RDK) stimuli were used to measure motion coherence thresholds in 366 children at risk of neurodevelopmental problems at 24 ?? 1 months of age. RDKs of variable coherence were presented and eye movements were analyzed offline to grade the direction of the optokinetic reflex (OKR) for each trial. Motion coherence thresholds were calculated by fitting psychometric functions to the resulting datasets. Test???retest reliability was assessed in 15 children, and motion coherence thresholds were measured in a group of 10 adults using OKR and behavioral responses. Standard age-appropriate optometric tests also were performed. Results. Motion coherence thresholds were measured successfully in 336 (91.8%) children using the OKR technique, but only 31 (8.5%) using behavioral responses. The mean threshold was 41.7 ?? 13.5% for 2-year-old children and 3.3 ?? 1.2% for adults. Within-assessor reliability and test???retest reliability were high in children. Children's motion coherence thresholds were significantly correlated with stereoacuity (LANG I & II test, ?? = 0.29, P < 0.001; Frisby, ?? = 0.17, P = 0.022), but not with binocular visual acuity (?? = 0.11, P = 0.07). In adults OKR and behavioral motion coherence thresholds were highly correlated (intraclass correlation = 0.81, P = 0.001). Conclusions. Global motion perception can be measured in 2-year-old children using the OKR. This technique is reliable and data from adults suggest that motion coherence thresholds based on the OKR are related to motion perception. Global motion perception was related to stereoacuity in children.

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  • Different dexamethasone regimens have different short term effects on growth and cardiovascular parameters in preterm infants treated for chronic lung disease

    Bloomfield, Francis; Knight, David; Harding, Jane (1997)

    Conference item
    The University of Auckland Library

    Bloomfield FH, Knight DB, Harding JE. Different dexamethasone regimens have different short term effects on growth and cardiovascular parameters in preterm infants &.. Proc 1st Ann Cong Perinatal Soc Australia/NZ, Fremantle, 1997, A15.

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  • Inter- and Intra-observer variability in the assessment of atelectasis and consolidation in neonatal chest radiographs.

    Bloomfield, Francis; Teele, RL; Voss, M; Knight, David; Harding, Jane (1999)

    Conference item
    The University of Auckland Library

    Bloomfield FH, Teele RL, Voss M, Knight DB, Harding JE. Inter- and Intra-observer variability in the assessment of atelectasis and consolidation in neonatal chest radiographs. Proc 3rd Ann Cong Perinatal Soc Australia/NZ, Melbourne 1999, P90.

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  • Intra-amniotic insulin-like growth factor (IGF)-I supplementation of the growth restricted fetal sheep alters IGF-I and IGF receptor type 1 mRNA and protein expression in placental and fetal tissues.

    Bloomfield, Francis; Sheikh, S; Phua, Hui; Bauer, Michael; Gilmour, RS; Harding, Jane (2004)

    Conference item
    The University of Auckland Library

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  • The importance of being a twin: within twin pair analysis of glucose tolerance and hypothalamic-pituitary-adrenal axis responsiveness

    Bloomfield, Francis; Oliver, Mark; Harding, Jane (2004)

    Conference item
    The University of Auckland Library

    BLOOMFIELD, F.H., OLIVER, M.H., HARDING, J.E. The importance of being a twin: within twin pair analysis of glucose tolerance and hypothalamic-pituitary-adrenal axis responsiveness . MedSciNZ Congress, Queenstown, C8, p65, 2004

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  • Maternal growth hormone and fetal intravenous and amniotic IGF-1 supplements improve growth in growth restricted fetal sheep.

    Eremia, Simona; Bloomfield, Francis; Oliver, Mark; Harding, Jane (2004)

    Conference item
    The University of Auckland Library

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  • The quality and completeness of cerebral ultrasound scanning may contribute to the variability in reported incidence of germinal matrix/intraventricular haemorrhage in New Zealand.

    Harris, Deborah; Bloomfield, Francis; Harding, Jane; Teele, RL (2004)

    Conference item
    The University of Auckland Library

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  • GH treatment of fetal sheep with placental insufficiency restores fetal IGF-1 plasma concentrations, but has different actions on selected organs

    Bauer, MK; Breier, Bernhard; Bloomfield, Francis; Jensen, EC; Gluckman, Peter; Harding, Jane (1999)

    Conference item
    The University of Auckland Library

    Bauer MK, Breier BH, Bloomfield FH & 3 others. GH treatment of fetal sheep with placental insufficiency restores fetal IGF-1 plasma concentrations, but has different actions on selected organs. Growth Hormone and IGF Research 1999;9:324.

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  • Intestinal effects of restricted growth in the ovine fetus can be reversed by intra-amniotic administration of low dose IGF-1.

    Bloomfield, Francis; Bauer, DB; Harding, Jane (1999)

    Conference item
    The University of Auckland Library

    Bloomfield FH, Bauer MK, Harding JE. Intestinal effects of restricted growth in the ovine fetus can be reversed by intra-amniotic administration of low dose IGF-1. Proc 3rd Ann Cong Perinatal Soc Australia/NZ, Melbourne 1999, P172.

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  • Maternal undernutrition and endocrine development

    Harding, Jane; Behrensdorf Derraik, Jose; Bloomfield, Francis (2010)

    Journal article
    The University of Auckland Library

    Maternal undernutrition, whether it occurs before conception, throughout gestation or during lactation, may lead to physiological adaptations in the fetus that will affect the health of the offspring in adult life. The timing, severity, duration and nature of the maternal nutritional insult may affect the offspring differently. Other factors determining outcome following maternal undernutrition are fetal number and gender. Importantly, effects of maternal undernutrition may be carried over into subsequent generations. This review examines the endocrine pathways disrupted by maternal undernutrition that affect the long-term postnatal health of the offspring. Maternal and childhood undernutrition are highly prevalent in low- and middle-income countries, and, in developed countries, unintentional undernutrition may arise from maternal dieting. It is, therefore, important that we better understand the mechanisms driving the long-term effects of maternal undernutrition, as well as identifying treatments to ameliorate the associated mortality and morbidity.

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  • Amniotic supplementation with IGF-I reverses the gastrointestinal effects of placental embolisation in the ovine fetus.

    Bloomfield, Francis; Bauer, MK; Gluckman, Peter; Harding, Jane (2000)

    Conference item
    The University of Auckland Library

    Bloomfield FH, Bauer MK, Gluckman PD, Harding JE. Amniotic supplementation with IGF-I reverses the gastrointestinal effects of placental embolisation in the ovine fetus. 82nd Annual Meeting of the Endocrine Society, Toronto 2000, A947.

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  • Neonatal chest physiotherapy does not prevent post-extubation atelectasis.

    Bloomfield, Francis; Teele, RL; Voss, M; Knight, David; Harding, Jane (1997)

    Conference item
    The University of Auckland Library

    Bloomfield FH, Teele RL, Voss M, Knight DB, Harding JE. Neonatal chest physiotherapy does not prevent post-extubation atelectasis. J Paediatr Child Health 33:A34, 1997.

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  • Chronic IGF-I infusion in healthy and IUGR late-gestation ovine fetuses: effects on fetal growth and placental function

    Bloomfield, Francis; Van zijl, PL; Bauer, MK; Harding, Jane (2001)

    Conference item
    The University of Auckland Library

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  • 'Effects of periconceptual undernutrition on the prepartum rise in circulating prostaglandin and cortisol concentrations in sheep'

    Kumarasamy, V; Mitchell, MD; Bloomfield, Francis; Oliver, MH; Harding, Jane (2003)

    Conference item
    The University of Auckland Library

    Kumarasamy, V., Mitchell, M.D., Bloomfield, F.H., Oliver, M.H., Harding, J.E. Effects of periconceptual undernutrition on the prepartum rise in circulating prostaglandin and cortisol concentrations in sheep . Annual Meeting of the Australian and New Zealand Placental Association, Sydney, 2003.

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  • Reported variation in the incidence of cerebral white matter changes may be due to differences in interpretation of scans.

    Harris, Deborah; Bloomfield, Francis; Teele, RL; Harding, Jane (2004)

    Conference item
    The University of Auckland Library

    HARRIS, D.L.5, BLOOMFIELD, F.H., TEELE, R.L.3, HARDING, J.E. Reported variation in the incidence of cerebral white matter changes may be due to differences in interpretation of scans. MedSciNZ Congress, Queenstown, C14, p76, 2004.

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  • Protocol for Sugar Babies Study

    Harris, DL; Weston, PJ; Battin, MR; Harding, Jane (2013-05-06)

    Unclassified
    The University of Auckland Library

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  • Nutritional interventions in the mothers - are we ready?

    Fall, CHD; Harding, Jane; Yajnik, CS (2009)

    Book item
    The University of Auckland Library

    Over the past 20 years a large body of research has accumulated, showing associations between birthweight and the risk of developing obesity, cardiovascular disease, type 2 diabetes and other health outcomes in later life. This has highlighted the importance of optimal fetal nutrition for lifelong health and has brought a renewal of interest, from policy makers, in improving maternal nutrition. In a 2006 report ???Repositioning nutrition as central to development??? the World Bank recommended that interventions to eradicate undernutrition in low-income countries should focus on pregnant women and children under 2 years of age in order to reap the greatest long-term benefits for human capacity and health [1]. The World Health Organisation highlighted the global burden of death, disability and lost human potential resulting from impaired fetal development [2]. And a series of papers published in the Lancet described the large burden of maternal and infant undernutrition in low-income countries and its adverse consequences throughout life [3, 4].

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  • Periconceptual undernutrition in the sheep causes premature activation of the hypothalamic-pituitary-adrenal (HPA) axis resulting in preterm birth.

    Bloomfield, Francis; Oliver, Mark; Hawkins, P; Challis, JRG; Harding, Jane (2001)

    Conference item
    The University of Auckland Library

    Objective: to investigate whether periconceptual undernutrition in sheep alters the timing and activation of the fetal HPA axis and thus pregnancy duration. Preterm birth is a major health problem, but its causes are poorly understood. Methods: Twentyeight nulliparous ewes were randomly assigned to an ad libitum (N, n=8) or restricted diet (maternal body weight reduced by 15-20%; UN, N=10) from 61 d before to 30 d after mating. Thereafter all ewes were fed ad libitum for the remainder of pregnancy. At 118 d vascular catheters were inserted in fetus and ewe and blood samples withdrawn at regular intervals until delivery. Ewes delivered normally and lambs were weighed and measured. Plasma samples were stored at -80 degC until analysis for cortisol (F), ACTH and progesterone (P4) by radioimmunoassay. Results: At surgery, there were no differences in fetal measurements between groups. UN fetuses delivered earlier than N fetuses (139.6 plus/minus 2.1 vs 145.1plus/minus 0.7 d, p lessthan 0.05 (Kaplan Meier survival analysis)) and 5 UN vs 0 N fetuses were preterm (<0.01) fell, significantly earlier than in term fetuses. There were no differences between UN and N groups in fetuses born at term. The ACTH to F ratio in preterm fetuses was twice that in term fetuses, consistent with the feed-forward loop seen in late-gestation, but was not significantly different between nutritional groups in term fetuses. Conclusion: We have shown for the first time that maternal periconceptual undernutrition results in precocious activation of the fetal HPA axis and preterm birth.

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  • Adult ovine HPA function is programmed by 10, but not 20, days of undernutrition in late gestation.

    Bloomfield, Francis; Oliver, Mark; Fraser, Mhoyra; Harding, Jane; Challis, JRG (2002)

    Conference item
    The University of Auckland Library

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