1 results for Abell, C

  • Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues

    Payne, RJ; Bulloch, Esther; Kerbarh, O; Abell, C (2010-08-07)

    Journal article
    The University of Auckland Library

    Several 2-amino-4-carboxypyridine, 4- and 5-carboxypyridone-based compounds were prepared and tested against three members of the chorismate-utilising enzyme family, anthranilate synthase, isochorismate synthase and salicylate synthase. Most compounds exhibited low micromolar inhibition of these three enzymes. The most potent inhibitor was a 4-carboxypyridone analogue bearing a lactate side chain on the pyridyl nitrogen which exhibited inhibition constants of 5, 91 and 54 ??M against anthranilate synthase, isochorismate synthase and salicylate synthase respectively.

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