1 results for Ames, R.
Wu, F.; Staykova, T.; Horne, A.; Clearwater, J.; Ames, R.; Mason, B.; Orr-Walker, B.; Gamble, G.; Scott, M.; Reid, I.R. (2003)
The University of Auckland Library
An open access copy of this article is available and complies with the copyright holder/publisher conditions. Aim: Treatment of vitamin D deficiency is an important aspect of the management of osteoporosis, particularly in the elderly. Most well-described regimens in current use involve daily dosing and thus require long-term compliance to be effective. In New Zealand, no preparation containing only low-dose vitamin D suitable for daily use is available. We describe a high-dose regimen for rapid correction of vitamin D deficiency, which makes use of the calciferol 50 000 international unit (IU) tablets available in this country. Methods: Thirty two women (mean age 76 ? 4 years; range 67-84 years) with serum 25-hydroxyvitamin D concentrations ?10 ?g/l were treated with oral calciferol 50 000 IU daily for 10 days. Results: At an average time after treatment of four months, serum 25-hydroxyvitamin D increased from 8 ? 1 ?g/l to 21 ? 5 ?g/l, bringing all but one patient within the reference range (14-76 ?g/l). Serum parathyroid hormone level decreased after treatment by 0.7 ? 1.7 pmol/l (p <0.001), but all values were within the reference range. Data collected from a separate cohort of elderly inpatients showed that similar increases could be achieved with a single 300 000 IU dose, and suggested that serum 25-hydroxyvitamin D levels decline with a half-life of 90 days. Conclusions: This regimen provides a simple, safe and effective way of managing vitamin D deficiency. Its short-term nature may result in higher compliance than daily dosing regimens.View record details