19 results for Hogan, NC

  • Jet injector use in oral evaluation

    Hunter, IW; Chen, Y; Hogan, NC; Ruddy, BP (2012)

    Patent
    The University of Auckland Library

    A tooth treatment device includes a detector that detects a marker of oral health and a fluid ejector that ejects fluid against teeth in response to the detected marker. The device can include a housing configured to be held on hand, the fluid ejector being positioned at an end of the housing. The fluid may include a liquid, a medicant, a cleansing solution, cleaning particles, or any combination thereof. The medicant can include any combination of a chelating agent, fluoride, a fluorescent dye, a bacterial specific probe, and a biochemical specific biomarker. Further, the device can include a servo controller controlling pressure of ejected fluid in response to the detected marker and a sensed surface condition, latter including for example, a mechanical property of tissue. The device may include a pressure sensor that senses pressure of the fluid in the ejector. Also included may be a distance sensor that senses distance of the ejector from a tissue surface. The surface condition may be sensed using the sensed pressure, sensed distance, or any combination thereof. In some embodiments, the fluid ejector comprises a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. A method of tooth treatment includes detecting a marker of oral health and controlling ejection of a fluid jet against the tooth responsive to the detected marker. In some embodiments, detecting the marker includes detecting plaque and the ejection is controlled to clean the plaque. Detecting the marker can include collecting a sample from an oral cavity.

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  • Needle-free jet injection using real-time controlled linear Lorentz-force actuators

    Taberner, Andrew; Hogan, NC; Hunter, Ian (2012-11)

    Journal article
    The University of Auckland Library

    Needle-free drug delivery by jet injection is achieved by ejecting a liquid drug through a narrow orifice at high pressure, thereby creating a fine high-speed fluid jet that can readily penetrate skin and tissue. Until very recently, all jet injectors utilized force- and pressure-generating principles that progress injection in an uncontrolled manner with limited ability to regulate delivery volume and injection depth. In order to address these shortcomings, we have developed a controllable jet injection device, based on a custom high-stroke linear Lorentz-force motor that is feed-back controlled during the time-course of an injection. Using this device, we are able to monitor and modulate continuously the speed of the drug jet, and regulate precisely the volume of drug delivered during the injection process. We demonstrate our ability to control injection depth (up to 16 mm) and repeatably and precisely inject volumes of up to 250 ??L into transparent gels and post-mortem animal tissue.

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  • Needle-free delivery of macromolecules through the skin using controllable jet injectors

    Hogan, NC; Taberner, Andrew; Jones, LA; Hunter, IW (2015-10)

    Journal article
    The University of Auckland Library

    INTRODUCTION: Transdermal delivery of drugs has a number of advantages in comparison to other routes of administration. The mechanical properties of skin, however, impose a barrier to administration and so most compounds are administered using hypodermic needles and syringes. In order to overcome some of the issues associated with the use of needles, a variety of non-needle devices based on jet injection technology has been developed. AREAS COVERED: Jet injection has been used primarily for vaccine administration but has also been used to deliver macromolecules such as hormones, monoclonal antibodies and nucleic acids. A critical component in the more recent success of jet injection technology has been the active control of pressure applied to the drug during the time course of injection. EXPERT OPINION: Jet injection systems that are electronically controllable and reversible offer significant advantages over conventional injection systems. These devices can consistently create the high pressures and jet speeds necessary to penetrate tissue and then transition smoothly to a lower jet speed for delivery of the remainder of the desired dose. It seems likely that in the future this work will result in smart drug delivery systems incorporated into personal medical devices and medical robots for in-home disease management and healthcare.

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  • Analysis of Moving-Coil Actuator Jet Injectors for Viscous Fluids.

    Williams, Rhys; Ruddy, Bryan; Hogan, NC; Hunter, IW; Nielsen, Poul; Taberner, Andrew (2016-06)

    Journal article
    The University of Auckland Library

    A jet injector is a device that can be used to deliver liquid drugs through the skin using a fluid jet, without the use of a needle. Most jet injectors are designed and used for the delivery of inviscid liquids, and are not optimized for the delivery of viscous drug compounds. To better understand the requirements for delivering viscous drugs, we have developed a mathematical model of the electromechanics of a moving-coil actuated jet injector as it delivers viscous fluids.The model builds upon previous work by incorporating the nonlinear electrical properties of the motor, compliant elements of the mechanical piston and ampoule system, and the effect of viscosity on injector characteristics. The model has been validated by monitoring the movement of the piston tip and measurements of the jet force.The results of the model indicate that the jet speed is diminished with increasing fluid viscosity, but overshoot and ringing in the jet speed is unaffected. However, a stiffer ampoule and piston will allow for a better control of the jet speed profile during an injection, and reduce ringing.We identified that the piston friction coefficient, the compliance of the injector components, and the viscous properties of the fluid are important determinants of performance when jet-injecting viscous fluids.By expanding upon previous jet injector models, this study has provided informative simulations of jet injector characteristics and performance. The model can be used to guide the design of future jet injectors for viscous fluids.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC

    Patent
    The University of Auckland Library

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  • Surface Injection Device

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, Dawn; Ball, NB; Hogan, NC (2010)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .

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  • Bi-directional motion of a lorentz-force actuated needle-free injector (NFI)

    Hunter, IW; Taberner, Andrew; Hogan, NC (2015-09-08)

    Patent
    The University of Auckland Library

    The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

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  • Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system

    Hunter, IW; Taberner, Andrew; Hogan, NC (2014-09-02)

    Patent
    The University of Auckland Library

    A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.

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  • Lorentz force linear actuator needle-free jet injection system to deliver solid and / or fluid

    Taberner, Andrew; Hunter, IW; Hogan, NC (2015-08-26)

    Patent
    The University of Auckland Library

    It means for conveying solids by the method of the surface of the organism, including (i) the electrical input applied to the controllable electromagnetic actuator; (ii) the actuator corresponding to said generated electrical machine with the electromagnetic input force; and (iii) applying mechanical force to the one end of the receptacle is coupled with the nozzle, the mechanical force generated pressure within the receptacle, with the magnitude of the pressure change and the mechanical force caused by the injection of fluid from the reservoir to drive solid into the organism. The method for delivering a substance to a target body, comprising (i) the needle-free injector near the surface of the target body; (ii) the substance injected into the target body; and (iii) at the same time injected, along the movement of the surface of the needle-free injector thus sweep the surface.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Hogan, NC; Ball, NB (2015-03-31)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2014-07-15)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Needle-free injector device with autoloading capability

    Hunter, IW; Hemond, BD; Wendell, DM; Hogan, NC; Taberner, Andrew; Ball, NB (2012-05-08)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

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  • Needle-free transdermal transport device

    Ball, NB; Hemond, BD; Hogan, NC; Hunter, IW; Taberner, Andrew; Wendell, DM (2009-08-16)

    Patent
    The University of Auckland Library

    needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Surface injection device

    Taberner, Andrew; Hunter, IW; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2010-09-29)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-freetransfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .

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  • Method and apparatus for extraction of a sample from a sample source

    Hunter, IW; Taberner, Andrew; Hogan, NC (2013-03-19)

    Patent
    The University of Auckland Library

    The present invention relate to a method and corresponding apparatus for extraction of a sample from a sample source. A fluid is injected into the sample source and the sample source is vibrated. A sample is withdrawn from the vibrated sample source and the sample source is evaluated by measuring one or more identifying parameters in the withdrawn sample.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Hogan, NC; Ball, NB (2012-12-11)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Needle-free injector device with autoloading capability

    Hunter, IW; Hemond, BD; Wendell, DM; Hogan, NC; Taberner, Andrew; Ball, NB (2014-03-25)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

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  • Surface injection device

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2010-10-27)

    Patent
    The University of Auckland Library

    Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules with specially designed jet passages at the injector's distal end.

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  • Injection methods using a servo-controlled needle-free injector

    Hemond, BD; Hunter, IW; Taberner, Andrew; Wendell, DM; Hogan, NC (2014-06-03)

    Patent
    The University of Auckland Library

    A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

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