7 results for Hunter, Peter, Conference poster

  • Modelling NFAT Cycling Sensitivity in the Cardiac Myocyte

    Cooling, Michael; Hunter, Peter; Crampin, Edmund (2007-10-01)

    Conference poster
    The University of Auckland Library

    The transcription factor NFAT acts as a signal integrator for a number of signal transduction pathways in cardiac myocytes that initiates gene expression in the disease Pathological Cardiac Hypertrophy[1]. Here we develop a quantitative mathematical model of the cytoplasmicnuclear-cytoplasmic cycling of NFAT in response to calcium signals in the cardiac myocyte

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  • Annotation of Clinical Datasets Using openEHR Archetypes

    Zivaljevic, Aleksandar; Atalag, Koray; de Bono, B; Hunter, Peter (2015-02-19)

    Conference poster
    The University of Auckland Library

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  • So what does linking computational models with clinical data mean and how to do it?

    Atalag, Koray; Kalbasi, R; Zivaljevic, Aleksandar; Nickerson, David; Warren, James; Cooling, M; Hunter, Peter (2017-02-23)

    Conference poster
    The University of Auckland Library

    Linking computational physiology models with clinical data has been proposed to help real-world model validation as well as enable personalised and predictive clinical decision support systems. Electronic health records (EHR) are sinks of biomedical knowledge and include manifestations of genomic and environmental aspects that impact on biological systems. We describe how to use openEHR to normalise, annotate and link clinical data with computational models.

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  • Bridging Computational Modelling and Clinical Information using openEHR and Semantic Web

    Atalag, Koray; Zivaljevic, Aleksandar; Kalbasi, R; Cooling, Michael; Nickerson, David; Hunter, Peter (2016-02-19)

    Conference poster
    The University of Auckland Library

    Linking clinical data to computational physiology is a crucial step for personalised and predictive Medicine. Electronic health records (EHR) embody quantifiable manifestations of genetic and environmental effects that impact on biological systems. Recent attempts to enable this linkage heavily rely on semantic technologies however in the world of EHRs Semantic Web has very limited use. openEHR provides open engineering specifications and tooling to tackle health data which supports Semantic Web. We are setting up an openEHR-based research data repository at ABI to normalise and annotate clinical and experimental data with an aim to integrate with the Physiome Model Repository (PMR).

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  • Multi-Scale and Multi-Physics Visualization

    Blackett, Shane; Bullivant, D; Nickerson, David; Hunter, Peter (2005-07-31)

    Conference poster
    The University of Auckland Library

    Accurate computational models of physiology require the coupling of different physical processes that occur across a wide range of spatial scales. The interpretation and analysis of the calculated results of these models require the integrated visualization of these multi-scale and multi-physics processes. A number of different strategies for doing this are presented for a model of the heart left ventricle.

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  • Visualizing multiscale models of the nephron

    Nickerson, David; Terkildsen, J; Hamilton, K; Hunter, Peter (2010-04)

    Conference poster
    The University of Auckland Library

    We present the development of a tool which provides users with the ability to visualize and interact with multiscale models of the nephron ??? from the scale of models of membrane bound proteins, to that of an individual nephron. A 1-D finite element model of the nephron has been created and is used for both visualization and modeling of the tubule transport. Mathematical models of nephron segments (for example, Weinstein et al., Am. J. Physiol. 292:F1164-F1181, 2007 for the proximal tubule) are embedded in the finite element model. At the cellular level these segment models utilize models encoded in CellML (www.cellml.org) to describe cellular transport kinetics. A user interface has been developed which allows the visualization and interaction with the multiscale nephron models and simulation results. The zinc extension to Firefox (http://www.cmiss.org/cmgui/zinc/) is used to provide an interactive 3-D view of the model(s). This model viewer is embedded in a web page which dynamically presents content based on user input. For example, when viewing the whole nephron model the user might be presented with information on the various embedded segment models as they select them in the 3-D model view. Similarly, the user might choose to focus the model viewer on a cellular model in a particular segment in order to view the various membrane transport proteins. Selecting a specific protein might present the user with a full reference description of the mathematical model governing the behavior of that protein (Nickerson et al., Bioinformatics 24:1112-1114, 2008).

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  • A Computational Model For Cerebral Circulation And Its Application For Haemodynamic Modelling In Vascular Surgeries

    Ho, Harvey; Mithraratne, K; Hunter, Peter (2009)

    Conference poster
    The University of Auckland Library

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