3 results for Park, K

  • A Study on the national/ethnic identity questions reflected in the post-1990s Korean Chinese novels: changes in the Joseonjok communities and their relationship with South Koreans and Han Chinese

    Song, Changzoo; Park, K (2010)

    Journal article
    The University of Auckland Library

    In this article, and the establishment of diplomatic relation between Korea and China's reform and opening up a significant number of ethnic Koreans in China as opportunity to move to Korea, while large cities appeared changing patterns of national identity, especially ethnic Koreans since the 1990s has been investigated as a novel target. Two weeks due to ethnic Koreans with an eye to changes in ethnic communities, the relationship between Koreans and examined the relationship between the Han. Community of ethnic Koreans in the form of the past two weeks due to the dissolution of reality can not be avoided, but a number of writers in the works for this show sadness and restoring hope for the community exposed. Related to Korea in spite of many negative experiences in the work meeting with South Korea and Koreans as a symbol of hope, community awareness of ethnic Koreans look was sunken, And when their ethnic identity be based in the mutual relationship between a station to be built in can see that. It also discussed the relationship between Han works with the co-existence and cooperation which they have an open mind and accept ethnic community while ethnic Koreans worry prescribed rituals revealed weakness, weakening national community should prepare for the preparedness showed that. Han ethnic Koreans from the artist's works with the new co-existence, convergence appears relationships, and meeting with Korea and Koreans look positively identified the fact that the work is vitally important. These works appeared in the writer's consciousness, the consciousness of the society, which represents ethnic Koreans bars, which are ethnic Koreans in China than in the position of small family Sumin access to mainstream society, and at the same time with the ethnic identity of Koreans admit that u 0 because that means that the visible.

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  • Quantitative model for the blood pressure-lowering interaction of valsartan and amlodipine

    Heo, Y-A; Holford, Nicholas; Kim, Y; Son, M; Park, K (2016-12)

    Journal article
    The University of Auckland Library

    Aims: The objective of this study was to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model to quantitatively describe the antihypertensive effect of combined therapy with amlodipine and valsartan. Methods: PK modelling was used with data collected from 48 healthy volunteers receiving a single dose of combined formulation of 10 mg amlodipine and 160 mg valsartan. Systolic (SBP) and diastolic blood pressure (DBP) were recorded during combined administration. SBP and DBP data for each drug alone were gathered from the literature. PKPD models of each drug and for combined administration were built with NONMEM 7.3. Results: A two-compartment model with zero order absorption best described the PK data of both drugs. Amlodipine and valsartan monotherapy effects on SBP and DBP were best described by an Imax model with an effect compartment delay. Combined therapy was described using a proportional interaction term as follows: (D1 + D2) +ALPHA??(D1 ?? D2). D1 and D2 are the predicted drug effects of amlodipine and valsartan monotherapy respectively. ALPHA is the interaction term for combined therapy. Quantitative estimates of ALPHA were ???0.171 (95% CI: ???0.218, ???0.143) for SBP and ???0.0312 (95% CI: ???0.07739, ???0.00283) for DBP. These infra-additive interaction terms for both SBP and DBP were consistent with literature results for combined administration of drugs in these classes. Conclusion: PKPD models for SBP and DBP successfully described the time course of the antihypertensive effects of amlodipine and valsartan. An infra-additive interaction between amlodipine and valsartan when used in combined administration was confirmed and quantified.

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  • New high fidelity polymerases from Thermococcus species

    Griffiths, K; Nayak, S; Park, K; Mandelman, D; Modrell, B; Lee, J; Ng, B; Gibbs, MD; Bergquist, Peter (2007)

    Journal article
    The University of Auckland Library

    Two DNA polymerase genes have been isolated from Thermococcus strains, Thermococcus zilligii from New Zealand, and the other, Thermococcus 'GT', a fast-growing strain isolated from the Galapagos trench. Both genes were isolated by genomic walking PCR, a technique that does not require expression of the gene product. Phylogenetic analysis of SSU rDNA showed that the two strains were not closely related, as confirmed by an examination of the DNA polymerase sequences. Inteintless versions of each gene were generated by overlap-extension PCR and transferred into plasmid expression vectors. The proteins were produced in an Escherichia coli strain with additional copies of tRNAs corresponding to rarely used codons and purified by standard chromatographic procedures. Both enzymes were able to support PCR, but the Thermococcus 'GT' polymerase required higher concentrations of template than the enzyme from T. zilligii. Both enzymes showed 3' to 5' exonuclease activity, which was abolished in the case of T zilligii by mutating the aspartic acid at position 141 and the glutamic acid at position 143 to alanine. Both enzymes showed a significant increase in fidelity of replication compared to the family A Thermus aquaticus DNA polymerase, in agreement with other results reported for family B polymerases with proofreading ability. (c) 2006 Elsevier Inc. All rights reserved.

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