71 results for Book, 2007

  • Critical pedagogy: where are we now?

    McLaren, Peter (2007)

    Book
    The University of Auckland Library

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  • Life in schools: an introduction to critical pedagogy in the foundations of education

    McLaren, Peter (2007)

    Book
    The University of Auckland Library

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  • Jade Taniwha: Māori-Chinese Identity and Schooling. Auckland: Rautaki.

    Lee, Jennifer (2007)

    Book
    The University of Auckland Library

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  • Psychiatry and the Law

    Brookbanks, Warren; Simpson, AIF (2007-05)

    Book
    The University of Auckland Library

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  • Xenophon on Government

    Gray, Vivienne (2007)

    Book
    The University of Auckland Library

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  • International Encyclopaedia of Laws: Conflict of Laws: South Africa

    Schoeman, Elsabe; Roodt, HC (2007)

    Book
    The University of Auckland Library

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  • Nietzsche and Rée: A Star Friendship

    Small, Robin (2007)

    Book
    The University of Auckland Library

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  • Lecture on Ethics: Introduction, Interpretation and Complete Text

    Wittgenstein, Ludwig (2007)

    Book
    The University of Auckland Library

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  • Ruling Class Men : money, sex, power

    Donaldson, M; Poynting, Noel (2007)

    Book
    The University of Auckland Library

    What is it like to be a master of the universe? The authors have researched the desires and fears of the world’s most powerful men. The Murdochs, Packers, Kennedys, Agnellis and other men like them, directly determine the fates of thousands and influence the future of the world like no other people. Described as ‘sacred monsters’ by one of their own, they are carefully created to be what they are and to enjoy shaping the world in their own likeness. To learn about these often reclusive men, the authors extended the life-history technique to interrogate autobiographies, diaries and biographies and have created a composite picture, a collective portrait, of tycoons over three generations. The book carefully explores the childhoods, schooling, work and play, sexual activities, marriages and deaths of the wealthiest men who have ever lived. It exposes the nature of ruling-class masculinity itself.

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  • Expanding Oral Language in the Classroom

    van Hees, Jennie Adriana (2007-04)

    Book
    The University of Auckland Library

    This book is about why and how teachers can realistically create and construct conditions that provide opportunities for each student's oral language development. A pilot research study underpinned the book contents, also drawing on a comprehensive literature review and the writer's own classroom-based practice and expertise. Within a research framework, it is a practical journey towards optimised language engagement and contribution by each member of the classroom community The book has become core reading for New Zealand teachers in oral language pedagogy and has served to foreground educational attention to expanding oral language in the classroom, To date, 861 copies have been sold, 72 internationally. There have been four reprints. To the author’s knowledge through personal communication with lecturers, it is a text used as part of two post graduate papers internationally: Education Research Institute, Melbourne University (Dr Janet Scull) and Monterey Institute of International Studies, Canada (Professor Leo van Lier).

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  • Teacher professional learning and development: Best evidence synthesis iteration

    Timperley, H; Wilson, A; Barrar, H; Fung, I (2007)

    Book
    The University of Auckland Library

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  • Criminal Justice in New Zealand

    Tolmie, Julia; Brookbanks, Warren (2007-11)

    Book
    The University of Auckland Library

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  • Public Transit Planning and Operation: Theory, Modeling and Practice

    Ceder, Avishai (2007)

    Book
    The University of Auckland Library

    Five groups of themes are addressed in the book: Overview of transit planning a Design and optimization of transit scheduling Passenger demand and assignment Transit service, network and route design Transit reliability

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  • Theories of Scientific Method

    Nola, Robert; Sankey, H (2007)

    Book
    The University of Auckland Library

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  • The Small Business Book - A New Zealand Guide for the 21st Century

    Oliver, Leith (2007)

    Book
    The University of Auckland Library

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  • Die Waage der Welt. Roman des Jahres 1932/1933.

    Stern, G (2007)

    Book
    The University of Auckland Library

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  • IEC 61499 Function Blocks for Embedded And Distributed Control Systems Design

    Vyatkin, Valeriy (2007)

    Book
    The University of Auckland Library

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  • Pedagogy and praxis in the age of empire: towards a new humanism / Peter McLaren and Nathalia Jaramillo.

    McLaren, Peter; Jaramillo, N (2007)

    Book
    The University of Auckland Library

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  • Peter Weiss' "Divina Commedia"-Projekt (1964-1969)

    Muellender, Yannick (2007)

    Book
    The University of Auckland Library

    Zur Zitierweise Die vorliegende Studie enthält Zitate aus unveröffentlichten Quellen, bei denen es sich zu einem Großteil um Arbeitsnotizen, ...

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  • Selective targeting of apoptotic pathways in follicular lymphoma cells

    Wlodkowic, Donald (2007)

    Book
    The University of Auckland Library

    The seminal discovery that the BCL2 gene inhibits cell death rather than promotes cell proliferation gave the foundation for a nowadays widely appreciated theory that impaired tumor cell death is a decisive stage in a multi-step carcinogenesis. Recognition of the central role of mitochondria and Bcl-2 family members in the regulation and propagation of cell demise has, thus, recently uncovered novel targets for selective anti-cancer therapies. In this context, we have for the first time demonstrated monotherapeutic potential of a small molecule Bcl-2 antagonist, HA14-1, against follicular lymphoma (FL) cells with t(14;18) translocation and Bcl-2 overexpression. In agreement with others we have shown that cytotoxicity mediated by a small molecule Bcl-2 inhibitor HA14-1 in FL cells proceeds through rapid (4h) dissipation of the ∆Ψm, generation of ROS and caspase-dependent apoptosis. Moreover, we were first to prove the applicability of combinatorial treatment of HA14-1 and selected conventional chemotherapeutics (dexamethasone and doxorubicin) in FL cells. In the following work we investigated the quantitative relationship between ∆Ψm loss and caspase activation in HA14-1 treated cells. Employing both pharmacological inhibitor studies and novel state-of-the-art multiparametric flow cytometry assays, we revealed that following HA14-1 treatment caspase activation occurs solely as a consequence of mitochondrial breach. Additionally, we provided new evidence that HA14-1-evoked apoptosis appears to be at least partially PT-dependent. We also for the first time addressed the cell cycle specificity of HA14-1 action using multivariate flow cytometry approaches. As the interest in the role of ER and Golgi during induction/execution of apoptosis has been gaining momentum, they simultaneously attract growing appreciation in the development of novel anti-cancer therapies. Pertinent to the therapy of B-cell malignancies we report here for the first time the effects of an ER-Golgi transport inhibitor, Brefeldin A (BFA), alone and in combination with a small molecule Bcl-2 inhibitor HA14-1 or death receptor trigger, in the human FL cell lines bearing t(14;18) translocation. Of importance for future anti-cancer regimens, small molecule Bcl-2 antagonist, HA14-1 and agonistic anti-Fas mAb significantly enhanced BFA- mediated cytotoxicity and apoptosis, revealing novel and previously unexplored avenues to enhance ER-stress mediated cell killing in B-cell malignancies. Finally, as basic studies advance towards their ultimate translational goals there is a need for effective and rapid analytical methods allowing high-throughput detection of diverse cell demise modes. In this context patented SYTO® probes are gaining increasing interest as easy to use markers of apoptosis. Herein, applying the state-of-the-art multiparametric flow cytometry and multicolor cell imaging we identified for the first time different SYTO16 staining characteristics upon apoptotic and oncotic stimuli. We also tracked similarities and discrepancies between SYTO16 and ∆Ψm, sensitive probe, tertramethylrhodamine methyl ester (TMRM), demonstrating that stimulation with mitochondrial uncoupler FCCP and a small-molecule Bcl-2 inhibitor, HA14-1, induce distinct staining profiles with the decrease in TMRM fluorescence preceding the loss of SYTO16 fluorescence. To our knowledge this is the first report demonstrating such a distinct behavior of SYTO16 and TMRM and our data demonstrate that loss of SYTO16 is caspase-dependent, as is not a mere indicator of ∆ψm dissipation, postulated previously by some authors.

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