1,995 results for Book item

  • Personalised information modelling technologies for personalised medicine

    Hu, Y; Kasabov, N; Liang, W (2014-03-21)

    Book item
    Auckland University of Technology

    Personalised modelling offers a new and effective approach for the study in pattern recognition and knowledge discovery, especially for biomedical applications. The created models are more useful and informative for analysing and evaluating an individual data object for a given problem. Such models are also expected to achieve a higher degree of accuracy of prediction of outcome or classification than conventional systems and methodologies. Motivated by the concept of personalised medicine and utilising transductive reasoning, personalised modelling was recently proposed as a new method for knowledge discovery in biomedical applications. Personalised modelling aims to create a unique computational diagnostic or prognostic model for an individual. Here we introduce an integrated method for personalised modelling that applies global optimisation of variables (features) and an appropriate size of neighbourhood to create an accurate personalised model for an individual. This method creates an integrated computational system that combines different information processing techniques, applied at different stages of data analysis, e.g. feature selection, classification, discovering the interaction of genes, outcome prediction, personalised profiling and visualisation, etc. It allows for adaptation, monitoring and improvement of an individual’s model and leads to improved accuracy and unique personalised profiling that could be used for personalised treatment and personalised drug design.

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  • Information methods for predicting risk and outcome of stroke

    Liang, L; Krishnamurthi, R; Kasabov, N; Feigin, V (2014-03-21)

    Book item
    Auckland University of Technology

    Stroke is a major cause of disability and mortality in most economically developed countries. It is the second leading cause of death worldwide (after cancer and heart disease) [55.1, 2] and a major cause of disability in adults in developed countries [55.3]. Personalized modeling is an emerging effective computational approach, which has been applied to various disciplines, such as in personalized drug design, ecology, business, and crime prevention; it has recently become more prominent in biomedical applications. Biomedical data on stroke risk factors and prognostic data are available in a large volume, but the data are complex and often difficult to apply to a specific person. Individualizing stroke risk prediction and prognosis will allow patients to focus on risk factors specific to them, thereby reducing their stroke risk and managing stroke outcomes more effectively. This chapter reviews various methods–conventional statistical methods and computational intelligent modeling methods for predicting risk and outcome of stroke.

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  • Ontologies and machine learning systems

    Tegginmath, S; Pears, R; Kasabov, N (2014-03-21)

    Book item
    Auckland University of Technology

    In this chapter we review the uses of ontologies within bioinformatics and neuroinformatics and the various attempts to combine machine learning (ML) and ontologies, and the uses of data mining ontologies. This is a diverse field and there is enormous potential for wider use of ontologies in bioinformatics and neuroinformatics research and system development. A systems biology approach comprising of experimental and computational research using biological, medical, and clinical data is needed to understand complex biological processes and help scientists draw meaningful inferences and to answer questions scientists have not even attempted so far.

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  • An extension of real life?: Understanding the experiences of two female chatroom operators.

    Bowker, N. (2005)

    Book item
    Open Polytechnic

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  • Emerging forms of identity online: Opportunities for extending theorising about identity through textual analysis.

    Bowker, N. (2012)

    Book item
    Open Polytechnic

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  • Corporate governance in Malaysia: Cosiness, cronyism and corruption.

    Chang, A. L. (2014)

    Book item
    Open Polytechnic

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  • Policies and strategies to improve nutrition and health for Indigenous peoples

    Kuhnlein, H; Burlingame, BA; Erasmus, B

    Book item
    Massey University

    false

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  • Why do Indigenous peoples food and nutrition interventions for health promotion and policy need special consideration

    Kuhnlein, H; Burlingame, BA

    Book item
    Massey University

    false

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  • Identities, roles, relationships and contexts in research

    White, CJ

    Book item
    Massey University

    false

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  • Writing here

    Horrocks, IA; Lacey, C

    Book item
    Massey University

    false

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  • Successful writing

    Kavan, Heather

    Book item
    Massey University

    No abstract

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  • The meaning of significance in data testing

    Perezgonzalez, JD

    Book item
    Massey University

    false

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  • The Brawn-Drain? Issues for the professional sports worker

    Sayers, Janet; Edwards, Margot

    Book item
    Massey University

    Professionalism is now the reality in many sports. For the professional sportsperson (most professional sports are male), there are several challenges and issues that make them a 'special' type of worker. We explore three of the challenges of the sports professional: the short-term nature of the career and its implications which includes living with injury and the fear of life after a sports career; second, the 'brawn drain'; and third, the celebrity status of athletes.

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  • Fisher, Neyman-Pearson or NHST? A tutorial for teaching data testing

    Perezgonzalez, JD

    Book item
    Massey University

    false

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  • Role of mathematical modelling and applications in university service courses: an across countries study

    Klymchuk, S; Zverkova, T

    Book item
    Auckland University of Technology

    The aim of this study was to find out what university students, studying mathematics as a service course, think about the role of the mathematical modelling process and application problems in their studies. For this purpose a questionnaire was given to more than 500 students from 14 universities in 9 countries. The research was not a comparison of countries or universities: an across countries study approach was chosen to reduce the affect of differences in education systems, curricula, cultures. The results of the questionnaire were analysed and presented in the paper. In particular, an attempt was made to identify which step of the mathematical modelling process the students found most difficult.

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  • Pacific youth connecting through Poly

    Fairbairn Dunlop, P

    Book item
    Auckland University of Technology

    No abstract.

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  • Brand equity and the value of marketing assets

    Brodie, RJ; Glynn, MS

    Book item
    Auckland University of Technology

    In the last two decades the term ‘equity’ has been used in marketing to describe the value of brands, customers, channels, and other marketing relationships. We examine the alternative uses of the equity concept and how it links with financial thinking. The chapter then explores issues involved in developing a theory of marketing assets and value that integrates branding, relationship and network thinking with financial thinking.

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  • Rapid biofunctionalization of magnetic beads with function-spacer-lipid constructs

    Henry, SM

    Book item
    Auckland University of Technology

    KODE™ Technology is based on novel water-dispersible self-assembling molecules, called a functionspacer- lipids or KODE™ constructs (Figure 1) that are able to coat virtually any biological or non-biological surface with almost any biological or non-biological material [1-10]. The primary coating method of live cells, organisms, bacteria and viruses or solid surfaces (glass, metals, plastics, etc.) is achieved by simple contact with a solution containing one or more FSL KODE™ constructs. Upon contact the FSLs spontaneously and harmlessly create a stable and novel surface coating. Essentially the spontaneous self-assembling process is driven by the need of the constructs to “exclude water”. Because the constructs are able to bind to virtually any surface, be it hydrophobic or hydrophilic the mechanisms of action are multiple and complex and include hydrophobic interactions (via lipid tail), hydrophilic interactions (via the head group and spacer), micelle entrapment, encapsulation, bi/multi layer assembly, and other factors such as hydrogen bonding, van der Waals forces, electrostatic and ionic interactions and combinations of all the above on complex surfaces. To-date a large range of peptides, simple and complex carbohydrates (including sialic acids and hyaluronin), peptides, fluorescent markers, reactive functional groups, biotin (Figure 1), oligonucleotides,radiolabels, chelators, and other functional moieties have been created as FSL constructs [1-10]. The key advantages of KODE™ Technology over other conjugation techniques are that it allows the user to create bespoke novel surfaces on demand, and it can also harmlessly modify live cells to facilitate their attachment to beads. Because multiple different FSL constructs can be added simultaneously to a bead, and in a controlled manner (by simply altering relative concentrations of FSLs in the mix), users can build on the surface of the bead a variety of complex multi-ligand biofunctional surfaces. Furthermore, the technology is compatible with existing functionalized beads and would allow users to add further features, such as fluorescent labels, or other enhancing or blocking components.

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  • Targeted screening for microbial bioactivity

    Stewart, Alison; Ohkura, M.; McLean, K.

    Book item
    Lincoln University

    High throughput screening technology has allowed significant advances to be made in the discovery of lead agents for use in the pharmaceutical and agrichemical industries. However, economic and practical constraints have limited the use of this technology in the identification of bioactive microbes targeted at crop pests and diseases. Smaller scale targeted screening programmes have generally provided greater success in identifying microbial bioactivity. This paper describes a strategy for targeted selection of bioactive Trichoderma spp. Isolates are selected for biological characteristics that best match the biocontrol blueprint developed for the target pathogen and are then put through a series of standardised bioassays. This strategy provides a rapid and cost-effective means of identifying biocontrol agents with commercial potential.

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  • Homogeneity of urban biotopes and similarity of landscape design language in former colonial cities

    Ignatieva, Maria; Stewart, Glenn H.

    Book item
    Lincoln University

    Colonial cities have remarkable similarities in their urban biotopes and landscape designs. The similar urban planning principles, landscape architectural styles, urban construction, and planting designs have produced an array of urban habitats that are replicated around the globe. From urban lawns to hedges and vegetation in pavement cracks, compositional similarity in urban biotopes is probably not surprising. But now, new concepts in individual planting design language such as "plant signatures", "go wild" and "alternative" or "freedom lawns" in North America, the United Kingdom, Australia, and New Zealand are producing a new ecological and cultural identity.

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