32 results for Conference poster, 2016

  • Considering clinical protocols and guidelines: what lessons for IPE?

    Barrow, Mark; Gasquoine, S (2016-08-30)

    Conference poster
    The University of Auckland Library

    Background: Interprofessional collaboration is enhanced if professionals work across discursive boundaries. While interprofessional education interventions may encourage this the practice environment may militate against the implementation of understandings developed in educational settings. Summary of work: Interviews with doctors and nurses highlighted differences between each professions’ views of clinical protocols and guidelines. This prompted us to conduct a critical discourse analysis of a number of clinical guidelines and the systems which guide their development and approval. Summary of results: Our analysis shows a range of discourses at work within clinical protocols régimes. Development and approval systems are dominated by collectivist discourses emphasising communication and collaboration within rigid bureaucratic systems. The protocols exemplify a neo-liberal discourse where people who are the objects of care are positioned as clients or consumers amenable to standardised aliquots of diagnosis and care, the level of which can be justified on the basis of scoring systems and claims related to a ‘scientific’ evidence base. The régimes also suggests (perhaps falsely) flattened hierarchical structures, a democratising discourse where all professional voices are equal in the provision of care. Discussion: A nursing identity relies on experience, holistic views of patients and collective approaches to practice. The medical identity is based on craft-based development of expertise associated with generating distinctive and sometime idiosyncratic responses to a patient’s needs. Each comes to protocols with different ‘agenda’. Conclusions: The collectivist discourse of protocol development does not seem to carry through to their utilisation. Protocols appear to act as objects that reinforce discursive boundaries between the groups. Take-home messages: Educators need to consider the effect of protocols on practice and account for this in the design of educational interventions. Understanding the discursive roll of protocols might help educators design more robust IPE programmes.

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  • Investigations At Hi-SEAS into Team Function and Performance on Long Duration Exploration Missions

    Binsted, KA; Basner, M; Bedwell, W; Caldwell, Bryan; Chang, D; Hunter, J; Kozlowski, S; Nasrini, J; Roma, P; Santoro, J; Seibert, M; Shiro, B; Wu, P (2016-02-09)

    Conference poster
    The University of Auckland Library

    HI-SEAS HI-SEAS (Hawaii Space Exploration Analog and Simulation, www.hi-seas.org) is a habitat on an isolated Mars-like site on the Mauna Loa side of the saddle area on the Big Island of Hawaii at approximately 8200 feet above sea level. HI-SEAS is unique, in addition to its setting in a distinctive analog environment, as: - we select the crew to meet our research needs (in contrast, at serendipitous analogs, such as Antarctic stations, crew selection criteria are not controlled by researchers); - the conditions (habitat, mission, communications, etc.) are explicitly designed to be similar to those of a planetary exploration mission; - the site is accessible year round, allowing longer-duration isolated and confined environment studies than at other locations; - the Mars-like environment offers the potential for analog tasks, such as geological field work by human explorers and/or robots. The ability to select crew members to meet research needs and isolate them in a managed simulation performing under specific mission profiles makes HI-SEAS ideal for detailed studies in space-flight crew dynamics, behaviors, roles and performance, especially for long-duration missions. MISSIONS TO DATE As of February 2016, there have been three missions completed at HI-SEAS, two of four months in length, and one of eight months. The fourth mission, which is twelve months long, is currently under way, and will end in August 2016. UPCOMING MISSIONS The next cycle of missions will see the research focus at HI-SEAS shift from crew cohesion and performance to crew composition. We expect the first of three eight-month missions to start in late 2016. CURRENT RESEARCH The current research projects being carried out at HI-SEAS focus on crew cohesion, function and performance. Preliminary results from each of these projects are being presented in detail by the co-authors separately at this meeting. This presentation will provide an overview of the research conducted to date, and the plans for the future. OPPORTUNISTIC RESEARCH In order to maximize research return, and to provide HI-SEAS crews with a realistic workload, we welcome proposals for opportunistic research to be carried out during HI-SEAS missions. Proposed projects must a) advance human space exploration by addressing NASA’s needs and requirements; b) require a long-duration analog for desired research outcomes; and c) not confound the primary research. If you are interested in submitting an opportunistic research proposal, please contact the first author.

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  • Pride and Prejudice: Social Workers’ Experiences of the Profession

    Staniforth, Barbara; Beddoe, Elizabeth (2016-06-28)

    Conference poster
    The University of Auckland Library

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  • Radiofrequency ablation of osteoid osteoma - aiming for zero recurrence

    Doyle, Anthony; Graydon, A; French, JG; Hanlon, M (2016-04-30)

    Conference poster
    The University of Auckland Library

    Over a 13 year period, a single radiologist (AJD) performed radiofrequency ablation (RFA)of osteoid osteoma in 32 patients. The lesions were located mostly in the lower extremities (femur N=15, tibia N=9) and spine (N=5). Lesion size varied from 4 to 18 mm, average 10 mm. Patient age ranged from 5 to 23 years, average 14 years. All but two had RFA as their primary treatment, with two treated after surgical excision had resulted in recurrence. CT guidance was used for all procedures, performed under general anaesthetic. A variety of different radiofrequency generators and probes were used. No complications occurred. None of the patients showed any signs of recurrence and none required further intervention. Although the followup period varied (and a few patients were lost to followup after a few weeks), most of the patients were followed for at least 12 months post procedure, with maximum followup seven years. We conclude that, with careful technique, the recurrence rate for RFA of osteoid osteoma can approach zero. Details of technique are discussed in the poster itself.

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  • LiDAR and EM conductivity investigation of a Holocene coastal landslide complex: Pourewa Landslide Zone, Auckland, New Zealand

    Liu, S; Brook, Martin; Richards, NP; Bevan, D; Prebble, W (2016-12-05)

    Conference poster
    The University of Auckland Library

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  • Rapid mapping of a Holocene coastal landslide using Structure-from-Motion (SfM) photogrammetry: Ohuka Landslide, Port Waikato, New Zealand

    Bevan, D; Brook, MS; Tunnicliffe, Jon; Prebble, W (2016-12-05)

    Conference poster
    The University of Auckland Library

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  • Quaternary geology of the Auckland urban region, New Zealand: geotechnical properties and engineering implications

    Brook, Martin; Roberts, R; France, S; Williams, AL; Prebble, W (2016-12-09)

    Conference poster
    The University of Auckland Library

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  • An optimal sampling schedule for neonates, infants & children receiving cefazolin +/- vancomycin for cardiopulmonary bypass

    Sturge, Jacqueline; Anderson, Brian; Holford, Nicholas (2016-08-22)

    Conference poster
    The University of Auckland Library

    Background: Dosing of prophylactic antibiotics in children during cardiopulmonary bypass (CPB) remains poorly defined. Pharmacokinetic (PK) studies can be improved using optimal design when sampling is limited, or multiple factors influence PK. We aimed to optimize a sampling schedule designed to determine cefazolin and vancomycin PK in children undergoing CPB. Methods: A one compartment distribution model for vancomycin and a three compartment distribution model for cefazolin was used with theory based allometric scaling and maturation to describe first-order elimination clearance. The CPB circuit was represented by an additional compartment. We assumed 60 subjects received cefazolin 50 mg.kg-1, with 50 of these subjects undergoing a procedure with CPB. We assumed 15 subjects also received 15 mg.kg-1 vancomycin. Optimal times for up to 8 samples per patient were estimated, ignoring CPB effects, using WinPOPT (University of Otago, New Zealand). Optimal sampling times for determination of CPB related changes were considered separately. Designs were selected based on relative standard errors (RSEs) for model parameters and comparison of criterions summarizing design efficiency. Results: Sample times were 0.001, 0.001, 0.108, 0.36, 1.05, 1.85 h following the first dose, and 0.36 and 2.5 h after the second dose, for With CPB subjects. Sample times were 0.127, 0.43, 0.43, 1.3, 3.18, 6, 6 h after the first dose and 6 h after the second dose, for Without CPB subjects. Five samples, taken directly from the CPB circuit, were required to adequately capture CPB related changes in CPB V and CL. RSE estimates of cefazolin, vancomycin and CPB circuit parameters for the final design were ≤ 30%, with the exception of one of the cefazolin volumes (V2) for which RSEs were 49%. Conclusion: The sampling schedule may be used in the planning of a clinical study of children receiving cefazolin and vancomycin during CPB.

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  • Loop closure and kinase selectivity in lung cancer

    Yosaatmadja, Yuliana; Squire, Christopher (2016-07-17)

    Conference poster
    The University of Auckland Library

    Lung cancer is a leading cause of cancer deaths worldwide. Somatic mutations in tyrosine kinase receptors that causes aberrant signalling have been implicated in the development of lung cancer. Two such receptors, EGFR and FGFR kinases are directly involved in many cases of aggressive metastasis and drug resistance. The FGFR kinase family consists of four highly conserved receptor proteins (FGFR1 ??? FGFR4). FGFR pathways are the main cause of resistance to chemotherapy in non-small cell lung cancer patients, and 22% of them show over-expression of FGFR1. There are a number of small molecules in phase III clinical trials that target not only FGFR but also other kinases. A wide range of EGFR mutations are linked to lung cancer development in never-smokers or former smokers. The two most common mutations are exon 19 deletions and the point mutation L858R in exon 21. Many patients harbouring L858R acquire a secondary T790M mutation after treatment with gefitinib/erlotinib resulting in drug resistance. In the past few years AstraZeneca have developed drugs that target specific proteins, eg; AZD4547 (FGFR1 selective) and AZD9291 (selectivity for T790M/L858R EGFR). In an effort to design our own novel and selective inhibitors, we solved the structures of AZD4547 and AZD9291 in complex with FGFR and EGFR respectively. In both cases, the phosphate binding loop (P-loop) of the proteins forms an unusual ???bent??? structure wrapped closely around these inhibitors. We speculate that the ability of these compounds to induce P-loop closure is an important part of their respective selectivity mechanisms.

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  • What should be stored in Biobanks? Using computational modelling to unravel genotype to phenotype linkage

    Cooling, Michael; Atalag, Koray (2016-10-31)

    Conference poster
    The University of Auckland Library

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  • Bridging Computational Modelling and Clinical Information using openEHR and Semantic Web

    Atalag, Koray; Zivaljevic, Aleksandar; Kalbasi, R; Cooling, Michael; Nickerson, David; Hunter, Peter (2016-02-19)

    Conference poster
    The University of Auckland Library

    Linking clinical data to computational physiology is a crucial step for personalised and predictive Medicine. Electronic health records (EHR) embody quantifiable manifestations of genetic and environmental effects that impact on biological systems. Recent attempts to enable this linkage heavily rely on semantic technologies however in the world of EHRs Semantic Web has very limited use. openEHR provides open engineering specifications and tooling to tackle health data which supports Semantic Web. We are setting up an openEHR-based research data repository at ABI to normalise and annotate clinical and experimental data with an aim to integrate with the Physiome Model Repository (PMR).

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  • Buried Faults in the Auckland Region

    Gasston, Caleb; Lindsay, Jan; Brook, MS (2016-12-09)

    Conference poster
    The University of Auckland Library

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  • Condicoes de saude dos indigenas menores de 5 anos Pataxo, MG, Brasil. Health conditions of the under 5 years old indigenous Pataxo children, MG, Brazil

    Santos, AP; Leite, MS; Conde, WL; Franco, MCP; Gontijo de Castro, Teresa (2016-10-29)

    Conference poster
    The University of Auckland Library

    Introdu????o: O quadro de sa??de dos povos ind??genas no Brasil ?? complexo e din??mico, est?? relacionado ao processo hist??rico de mudan??as econ??micas, sociais e ambientais (Santos & Coimbra Jr., 2003). Altas preval??ncias de d??ficit estatural (25,7%) tem acometido as crian??as ind??genas brasileiras e diarreia e infec????o respirat??ria aguda sao apontadas como as maiores causas de interna????o hospitalar notificada (Horta et al., 2013; Leite et al., 2013; Coimbra et al., 2013). Objetivo: Dentre os menores de 5 anos Pataxo de Minas Gerais: 1) descrever caracter??sticas de nascimento, situa????o vacinal, acompanhamento do pre-natal e do crescimento e desenvolvimento, perfil de morbidades e acessos aos servi??os de sa??de; 2) verificar associacoes entre estado nutricional e condicoes de saude observadas. Metodologia: Estudo epidemiol??gico de base populacional, natureza transversal, com dados coletados em 2011 entre os Patax?? de Minas Gerais. Foram avaliadas 34 crian??as (< 5 anos) residentes em 5 aldeias do povo Patax??, localizadas nos munic??pio de Carm??sia, Itapecerica e A??ucena. A avalia????o da situa????o de sa??de utilizou question??rio estruturado baseado no Primeiro Inqu??rito Nacional de Sa??de e Nutri????o dos Povos Ind??genas (Cardoso et al., 2009). A aferi????o das medidas antropom??tricas (peso, estatura/comprimento e circunfer??ncia da cintura) foi realizada de acordo com as recomenda????es da Organiza????o Mundial da Sa??de. O presente estudo foi aprovado pelo comit?? de ??tica da Universidade Federal de S??o Paulo pela Comiss??o Nacional de ??tica em Pesquisa. Foram calculadas freq????ncias de vari??veis categ??ricas e m??dias (desvios-padr??o) e medianas das vari??veis cont??nuas. Para a identifica????o de diferen??as entre as m??dias utilizou o teste t de Student, enquanto propor????es foram comparadas pelo teste do qui-quadrado de Pearson, adotando-se P< 0,05. Utilizou-se o programa SPSS (17.0) para analise dos dados. Resultados: Entre os menores de 5 anos, 55,9% eram do sexo feminino e 44,1% tinham idade inferior a 24 meses. A maioria das crian??as nasceu no hospital, e 82,4% das maes tiveram 6 ou mais consultas de pre-natal. Mais de 80% das mesmas estavam com o esquema vacinal em dia a ??poca da pesquisa e havia tomado a megadose de vitamina A. Apenas 8,8% das crian??as tinham o registro do acompanhamento do crescimento no ??ltimo m??s anterior a pesquisa. A preval??ncia de hospitaliza????o nos ??ltimos 12 meses foi de 23,5%, mas nenhuma interna????o foi devida a infec????es respirat??rias e apenas uma crian??a foi internada com diarreia. Ocorr??ncia de diarreia na ??ltima semana foi relatada para 17,6% das crian??as e tosse para 35,3%. Devido ao fato dos d??ficits estaturais e ponderais serem inexistentes nesta popula????o e o excesso de peso ter acometido somente uma das crian??as, n??o foi poss??vel verificar a distribui????o dos dist??rbios nutricionais de acordo com as vari??veis independentes, de forma a verificar-se poss??veis associa????es. Conclus??es: Comparado com a populacao de criancas indigenas brasileiras, alguns indicadores de saude entre os Pataxo tiveram melhor desempenho, como a baixa preval??ncia de interna????o hospitalar reportada para diarreia e IRAs, a alta cobertura vacinal e o percentual de gestantes que tiverm 6 ou mais consultas pre-natal. No entanto, melhorias na periodicidade de acompanhamento do crescimento e desenvolvimento sao necessarias.

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  • What is the host range of Phytophthora agathidicida in New Zealand

    Ryder, Jessica; Burns, Bruce (2016-08-08)

    Conference poster
    The University of Auckland Library

    hytophthora agathidicida is a virulent oomycete plant pathogen, which is currently known to only infect Agathis australis in New Zealand. Phytophthora species rarely have a single plant host, so other hosts for P. agathidicida are likely but unknown. Phytophthora species are also often cryptic and sometimes asymptomatic on their host plants, making it a challenge to identify their true host range. Once an exotic Phytophthora species is introduced to an area, it becomes virtually impossible to eliminate. A sound understanding of a Phytophthora???s epidemiology is needed to prevent its spread onto uninfected hosts. This study determined whether P. agathidicida has a wider host range than currently recognised. Plant community composition was compared between healthy and infected kauri forest to detect possible susceptible species, and detached leaf assays were utilised as a further screen of possible hosts. Results showed a significant difference in species abundances between sites infected with P. agathidicida and sites without P. agathidicida that was unrelated to other potential variables. Leaf assays also indicated several other native plant species other than A.australis as possible carriers or hosts, including Knightia excelsa and Leucopogon fasciculatus. Identifying the host range of P. agathidicida is important for optimising the design of future control strategies for this pathogen.

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  • Urea cycle enzymes and peptidylarginine deiminase in Alzheimer's superior frontal gyrus

    Cicolini, J; Jing, Y; Waldvogel, Henry; Faull, Richard; Liu, P (2016-07-24)

    Conference poster
    The University of Auckland Library

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  • The spirit that is one's own: A conversation in two tongues, Ko te wairua n?? te tangata ake: He whakawhitiwhiti k??rerorero ki roto i ng?? reo e rua

    Dattaray, D; Keegan, Peter (2016-11-17)

    Conference poster
    The University of Auckland Library

    Indigenous epistemes and philosophies help one understand ethical responsibilities in a changing world, between knowing and learning. Aesthetic, socio-political, cultural and normative aspects of human existence are reflected in Indigenous narrative traditions and language practices. This paper attempts to forge connections between the historical and discursive Indigenous practices of M??ori of New Zealand and Karbis from the North East of India. M??ori are the only indigenous group in New Zealand. M??ori are now highly urbanized, in a largely English speaking and Western dominated context, yet have made important gains in language and cultural revitalization. The North East of India today is a profound paradox that simultaneously represents the frontiers of globalization as well as a heritage of Indigenous traditions and cultures. In present-day India, the ???North East??? often denotes a sense of geographical isolation and is perceived as a region of ethnic strife and violence. North East is also a treasure trove of culture and tradition belonging to hundreds of Indigenous communities from the region. Through an interdisciplinary dialogue, the paper attempts a rethink on issues of public accessibility, intellectual and cultural property rights. Further, it underlines the significance of reciprocal education and training in the context of Indigeneity.

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  • Lower Limb Estimation from Sparse Landmarks using an Articulated Shape Model

    Zhang, Ju; Hislop-Jambrich, J; Besier, Thor (2016-02-19)

    Conference poster
    The University of Auckland Library

    Rapid generation of lower limb musculoskeletal models is essential for patient-specific gait modeling. Motion-capture is a routine part of gait assessment but contains relatively sparse geometric information. We present an articulated statistical shape model of the lower limb that estimates realistic bone geometry, pose, and muscle attachment regions from seven commonly used motion-capture markers. Our method obtained a lower (p=0.02) surface error of 4.5 mm RMS compared to 8.5 mm RMS using standard isotropic scaling, and was more robust, converging in all 26 test cases compared to 20 for isotropic scaling.

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  • Measuring mindfulness at interval level: Transformation of the Five Facet Mindfulness Questionnaire using Rasch approach

    Medvedev, Oleg; Siegert, RJ; Kerston, P; Kr??geloh, CU (2016-05-13)

    Conference poster
    The University of Auckland Library

    Introduction: Significant contribution of mindfulness to individuals??? health and well-being requires precise mindfulness measures for accurate assessment of psychological and cognitive changes in individuals undergoing mindfulness-based interventions. The widely used measure of trait mindfulness the 39-item Five Facet Mindfulness Questionnaire (FFMQ; Baer, Smith, Hopkins, Krietemeyer, & Toney, 2006) including: Observing, Describing, Act With Awareness, Non-Judging and Non-reacting to inner experience has shown acceptable psychometric properties but no efforts were made to increase precision of its subscales in discriminating between trait levels. Method: Rasch analysis was conducted to enhance the psychometric properties of the FFMQ using sample of 296 participants. Results: The best fit to the Rasch model was achieved for all five FFMQ subscales after minor modifications that involved combining locally dependent items into subtests and removing two items that critically affected the estimates. Discussion: Findings support structural validity of the FFMQ subscales and allow researchers and clinicians transform ordinal FFMQ responses to interval level data suitable for parametric statistics, which increases measurement precision. Conversion tables are included here for convenience and can be used without any modifications of the original FFMQ response format. Further implications of these findings are discussed.

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  • Evaluation of liquefaction susceptibility using the critical state soil mechanics concept

    Orense, Rolando; Tan, Wei Yoong (2016-04-01)

    Conference poster
    The University of Auckland Library

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  • First proteomic profiling of exosomes in rodent intestinal lymph

    Hong, Jiwon; Nachkebia, S; Tun, SM; Premkumar, R; Blenkiron, C; Windsor, John; Phillips, Anthony (2016-05-06)

    Conference poster
    The University of Auckland Library

    Introduction: Exosomes are released by many cell types and can be taken up by other cells. They may play an important role in cell-to-cell communication and disease pathogenesis. Exosomes derived from plasma or urine have been extensively studied, but that of intestinal lymph has not been reported due to the difficulty in obtaining these samples. Intestinal lymph is continuously draining from the intestine and enters the veins just before the heart and lungs. These organs may therefore be directly influenced by intestinal exosomes. Methods: Intestinal lymph was collected from a rodent experimental model of critical illness. Exosomes were isolated from the intestinal lymph using a commercially available exosome isolation kit. Particle size and concentration were determined by Nanosight. Proteomic profiling of lymph exosomes and its changes in critical illness were analysed by LC-MS. Results: The size and concentration of ???exosomes??? isolated from the intestinal lymph did not change significantly in the critical illness. The exosome preparation contained proteins previously identified in microparticles or exosomes (e.g. inter-alpha trypsin inhibitor), but also the highly abundant plasma proteins (e.g. complement C3, albumin). Common exosomal markers (e.g. TSG101, CD63) were not detected. Instead, substantial amounts of Apo B and A-I were found, indicating presumed co-isolation of chylomirons. Lymph chylomicrons are similar to size of ???exosomes???, and produced in high concentration from the intestine. Our study indicates the unexpected difficulty in isolating pure exosomes using a commercial kit in this unique fluid. Conclusion: This present study provides the first attempt at a proteomic profile of an exosome preparation from intestinal lymph. Collectively, multiple proteins were identified, but found to have come from both exosomes and chylomicrons. New purification methods will be needed to study pure isolates of each particle type in this unique fluid.

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