277 results for Conference poster

  • Condicoes de saude dos indigenas menores de 5 anos Pataxo, MG, Brasil. Health conditions of the under 5 years old indigenous Pataxo children, MG, Brazil

    Santos, AP; Leite, MS; Conde, WL; Franco, MCP; Gontijo de Castro, Teresa (2016-10-29)

    Conference poster
    The University of Auckland Library

    Introdu????o: O quadro de sa??de dos povos ind??genas no Brasil ?? complexo e din??mico, est?? relacionado ao processo hist??rico de mudan??as econ??micas, sociais e ambientais (Santos & Coimbra Jr., 2003). Altas preval??ncias de d??ficit estatural (25,7%) tem acometido as crian??as ind??genas brasileiras e diarreia e infec????o respirat??ria aguda sao apontadas como as maiores causas de interna????o hospitalar notificada (Horta et al., 2013; Leite et al., 2013; Coimbra et al., 2013). Objetivo: Dentre os menores de 5 anos Pataxo de Minas Gerais: 1) descrever caracter??sticas de nascimento, situa????o vacinal, acompanhamento do pre-natal e do crescimento e desenvolvimento, perfil de morbidades e acessos aos servi??os de sa??de; 2) verificar associacoes entre estado nutricional e condicoes de saude observadas. Metodologia: Estudo epidemiol??gico de base populacional, natureza transversal, com dados coletados em 2011 entre os Patax?? de Minas Gerais. Foram avaliadas 34 crian??as (< 5 anos) residentes em 5 aldeias do povo Patax??, localizadas nos munic??pio de Carm??sia, Itapecerica e A??ucena. A avalia????o da situa????o de sa??de utilizou question??rio estruturado baseado no Primeiro Inqu??rito Nacional de Sa??de e Nutri????o dos Povos Ind??genas (Cardoso et al., 2009). A aferi????o das medidas antropom??tricas (peso, estatura/comprimento e circunfer??ncia da cintura) foi realizada de acordo com as recomenda????es da Organiza????o Mundial da Sa??de. O presente estudo foi aprovado pelo comit?? de ??tica da Universidade Federal de S??o Paulo pela Comiss??o Nacional de ??tica em Pesquisa. Foram calculadas freq????ncias de vari??veis categ??ricas e m??dias (desvios-padr??o) e medianas das vari??veis cont??nuas. Para a identifica????o de diferen??as entre as m??dias utilizou o teste t de Student, enquanto propor????es foram comparadas pelo teste do qui-quadrado de Pearson, adotando-se P< 0,05. Utilizou-se o programa SPSS (17.0) para analise dos dados. Resultados: Entre os menores de 5 anos, 55,9% eram do sexo feminino e 44,1% tinham idade inferior a 24 meses. A maioria das crian??as nasceu no hospital, e 82,4% das maes tiveram 6 ou mais consultas de pre-natal. Mais de 80% das mesmas estavam com o esquema vacinal em dia a ??poca da pesquisa e havia tomado a megadose de vitamina A. Apenas 8,8% das crian??as tinham o registro do acompanhamento do crescimento no ??ltimo m??s anterior a pesquisa. A preval??ncia de hospitaliza????o nos ??ltimos 12 meses foi de 23,5%, mas nenhuma interna????o foi devida a infec????es respirat??rias e apenas uma crian??a foi internada com diarreia. Ocorr??ncia de diarreia na ??ltima semana foi relatada para 17,6% das crian??as e tosse para 35,3%. Devido ao fato dos d??ficits estaturais e ponderais serem inexistentes nesta popula????o e o excesso de peso ter acometido somente uma das crian??as, n??o foi poss??vel verificar a distribui????o dos dist??rbios nutricionais de acordo com as vari??veis independentes, de forma a verificar-se poss??veis associa????es. Conclus??es: Comparado com a populacao de criancas indigenas brasileiras, alguns indicadores de saude entre os Pataxo tiveram melhor desempenho, como a baixa preval??ncia de interna????o hospitalar reportada para diarreia e IRAs, a alta cobertura vacinal e o percentual de gestantes que tiverm 6 ou mais consultas pre-natal. No entanto, melhorias na periodicidade de acompanhamento do crescimento e desenvolvimento sao necessarias.

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  • Extracellular RNA profiles of rat mesenteric lymph

    Hong, Jiwon; Tsai, P; Blenkiron, Cherie; Premkumar, R; Nachkebia, S; Hickey, Anthony; Windsor, John; Phillips, Anthony (2017-06-09)

    Conference poster
    The University of Auckland Library

    Recent discoveries suggests that some RNA species are stable outside the cells and can play in cell-to-cell communication and other biological or disease processes. Such extracellular RNAs have been found in a variety of body fluids including plasma and urine, but are yet to be studied in detail in mesenteric lymph (ML). We performed RNA sequencing analysis on rat ML and plasma, and compared their RNA profiles. In addition, extracellular vesicle (EV)- and triglyceride-rich lipoprotein (TRL)-enriched fractions were isolated from ML using Macherey-Nagel exosome precipitation solution and differential ultracentrifugation, respectively, and their RNA profiles were also compared. We found that each sample type had a distinct RNA profile. Interestingly, ML contained a large proportion (>80%) of rat tRNA fragments and <2%). The TRL fraction of ML had very low RNA, suggesting that TRLs might not be the major carriers of RNA in ML. Interestingly, ML, which constantly drains the gut, has a greater abundance of non-rodent sequences than the plasma, and some of these were mapped to bacteria. This is the first report on the RNA profile of ML.

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  • First proteomic profiling of exosomes in rodent intestinal lymph

    Hong, Jiwon; Nachkebia, S; Tun, SM; Premkumar, R; Blenkiron, C; Windsor, John; Phillips, Anthony (2016-05-06)

    Conference poster
    The University of Auckland Library

    Introduction: Exosomes are released by many cell types and can be taken up by other cells. They may play an important role in cell-to-cell communication and disease pathogenesis. Exosomes derived from plasma or urine have been extensively studied, but that of intestinal lymph has not been reported due to the difficulty in obtaining these samples. Intestinal lymph is continuously draining from the intestine and enters the veins just before the heart and lungs. These organs may therefore be directly influenced by intestinal exosomes. Methods: Intestinal lymph was collected from a rodent experimental model of critical illness. Exosomes were isolated from the intestinal lymph using a commercially available exosome isolation kit. Particle size and concentration were determined by Nanosight. Proteomic profiling of lymph exosomes and its changes in critical illness were analysed by LC-MS. Results: The size and concentration of ???exosomes??? isolated from the intestinal lymph did not change significantly in the critical illness. The exosome preparation contained proteins previously identified in microparticles or exosomes (e.g. inter-alpha trypsin inhibitor), but also the highly abundant plasma proteins (e.g. complement C3, albumin). Common exosomal markers (e.g. TSG101, CD63) were not detected. Instead, substantial amounts of Apo B and A-I were found, indicating presumed co-isolation of chylomirons. Lymph chylomicrons are similar to size of ???exosomes???, and produced in high concentration from the intestine. Our study indicates the unexpected difficulty in isolating pure exosomes using a commercial kit in this unique fluid. Conclusion: This present study provides the first attempt at a proteomic profile of an exosome preparation from intestinal lymph. Collectively, multiple proteins were identified, but found to have come from both exosomes and chylomicrons. New purification methods will be needed to study pure isolates of each particle type in this unique fluid.

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  • Energy and nutrient modelling of human evolution

    McGill, Anne-Thea; Wake, G; Beedle, Alan (2010-10)

    Conference poster
    The University of Auckland Library

    ENERGY AND NUTRIENT MODELLING OF HUMAN EVOLUTION Background. During evolution, human encephalisation resulted in high energy use by the large brain in proportion to the body. Adaptations to increase energy intake or reduce total body energy to redress this imbalance may have involved 1) highly developed neural appetite pathways including the dopaminergic mesocorticolimbic self -reward system to enhance energy dense food intake 2) an expensive tissue trade off including a short adaptable gut that relies on a higher energy omnivorous diet 3) slow growth and development and thus careful preservation of cellular integrity to reduce oxidative stress and allow longevity 4) inhibition/alteration of energy expensive vitamin and co-factor synthesis and a dependence on the wide variety of food micronutrients. It appears that many such food micronutrients are modulating cellular energy use, and that micronutrient quality must be built into energy requirements. Concurrently, humans were developing technologies such as tool use and fire to further expand food quality and quantity. However, the neural self reward aspect systems pushed technology to favour high and secure energy yields. Animal husbandry and plant crop farming lead to selective breeding for high fat, starch and sugar produce, at the expense of micronutrient variety and volume. Once technology progressed to factory farming, and mechanised and chemical food processing systems, proportions of food micronutrients/macronutrients were markedly altered. Humans are driven to consume addictive energy dense foodstuffs but (unconsciously) neglect to acquire adequate micronutrient volumes. They are forced to attempt to store the energy firstly safely in subcutaneous adipose, then centrally around viscera, and finally in non-adipose cells where glycolipotoxicity occurs. Aims: We plan to start developing new dynamic energy equations, with reference to Dynamic Energy Budget (DEB) models for other biological systems. Ultimately, the ???ideal??? prehistoric fit and healthy, lean hunter-gatherer will be compared with the contemporary sedentary and (metabolically) degenerate, obese ???westernised-diet??? consuming human. Method: Principles of DEB and mathematical modelling of energy use will be reviewed with respect to human metabolism and different diets.

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  • Applying threshold concepts to unlock the ???hidden??? core of a multifaceted health sciences curriculum

    Petersen, Mary; Egan, John; Barrow, Mark (2015-07-07)

    Conference poster
    The University of Auckland Library

    Title: Applying threshold concepts to unlock the ???hidden??? core of a multifaceted health sciences curriculum Background/context: In 2014, a curriculum implementation plan was developed to comprehensively map the existing Bachelor of Health Sciences (BHSc) curriculum so as to inform a cohesive workforce-related vision for the future. However, prior to mapping the curriculum, staff first needed to agree upon what the future-focused set of graduate capabilities across their diverse programme should be. To do so, we applied Meyer and Land???s (2003) notion of threshold concepts to enable us to unpack and clarify what felt like a complex, and at times hidden, core curriculum. Research/evaluation method: The existing BHSc programme was analysed using the frame of threshold concepts through a series of staff and student focus group sessions. This led to a refining of six central threshold concepts for the degree. This in turn informed the revision of a set of programme-wide graduate capabilities. Pre-review course outlines (n=24) and assessments (n=104) were analysed using thematic coding in NVivo and then mapped against the proposed graduate capabilities and thresholds for the revised BHSc. Lecturers validated these data using co-constructed matrices to explore coverage of these thesholds across the programme. At the end of 2014, teaching staff involved in the curriculum project (n=14) completed an evaluation analysing their perception of the effects of applying threshold concepts to their own development, and to their BHSc programme knowledge development. Outcomes: Evaluation results indicate that staff now report a greater common sense of purpose, increased collegiality and a more clarified overarching vision for the BHSc programme (which encompasses at least six distinct pathways of learning within the health sciences). By applying the frame of threshold concepts to the programme curriculum, many staff reported surprise that ???taken for granted??? competencies such as academic, information and professional literacies were not actually being systematically built upon across the three years of the BHSc. This has been the springboard to a programme-wide redevelopment of the BHSc core courses assisted by external health sector representatives. Additionally, two new complementary ???capstone??? courses have been planned for stage three of the programme which will more purposefully address real-world, essential graduate capabilities. How the conference sub-themes are addressed (200 words): This poster focuses centrally on conference theme one by exploring how threshold concepts can assist the process of establishing what capabilities are required of (BHSc) graduates and how we can ensure these are responsive to (health) sector needs. It highlights examples from practice in the Bachelor of Health Sciences programme. We first show how an overarching programme purpose was reframed in conjunction with external sector input by utilising Meyer & Land???s notion of threshold concepts. Next we illustrate examples of effective tools and processes (co-constructed matrices) that were applied by academic staff to shed light on gaps and overlaps in existing core course content and assessment tasks. Related to this we address questions from conference theme three concerned with how we can assess, embed and evaluate these graduate capabilities once we have mapped them across our courses. Examples also illustrate the processes utilised in designing stage three ???capstone??? courses to embed and assess these graduate capabilities.

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  • Investigations At Hi-SEAS into Team Function and Performance on Long Duration Exploration Missions

    Binsted, KA; Basner, M; Bedwell, W; Caldwell, Bryan; Chang, D; Hunter, J; Kozlowski, S; Nasrini, J; Roma, P; Santoro, J; Seibert, M; Shiro, B; Wu, P (2016-02-09)

    Conference poster
    The University of Auckland Library

    HI-SEAS HI-SEAS (Hawaii Space Exploration Analog and Simulation, www.hi-seas.org) is a habitat on an isolated Mars-like site on the Mauna Loa side of the saddle area on the Big Island of Hawaii at approximately 8200 feet above sea level. HI-SEAS is unique, in addition to its setting in a distinctive analog environment, as: - we select the crew to meet our research needs (in contrast, at serendipitous analogs, such as Antarctic stations, crew selection criteria are not controlled by researchers); - the conditions (habitat, mission, communications, etc.) are explicitly designed to be similar to those of a planetary exploration mission; - the site is accessible year round, allowing longer-duration isolated and confined environment studies than at other locations; - the Mars-like environment offers the potential for analog tasks, such as geological field work by human explorers and/or robots. The ability to select crew members to meet research needs and isolate them in a managed simulation performing under specific mission profiles makes HI-SEAS ideal for detailed studies in space-flight crew dynamics, behaviors, roles and performance, especially for long-duration missions. MISSIONS TO DATE As of February 2016, there have been three missions completed at HI-SEAS, two of four months in length, and one of eight months. The fourth mission, which is twelve months long, is currently under way, and will end in August 2016. UPCOMING MISSIONS The next cycle of missions will see the research focus at HI-SEAS shift from crew cohesion and performance to crew composition. We expect the first of three eight-month missions to start in late 2016. CURRENT RESEARCH The current research projects being carried out at HI-SEAS focus on crew cohesion, function and performance. Preliminary results from each of these projects are being presented in detail by the co-authors separately at this meeting. This presentation will provide an overview of the research conducted to date, and the plans for the future. OPPORTUNISTIC RESEARCH In order to maximize research return, and to provide HI-SEAS crews with a realistic workload, we welcome proposals for opportunistic research to be carried out during HI-SEAS missions. Proposed projects must a) advance human space exploration by addressing NASA???s needs and requirements; b) require a long-duration analog for desired research outcomes; and c) not confound the primary research. If you are interested in submitting an opportunistic research proposal, please contact the first author.

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  • Are doctoral theses changing over time?

    Brailsford, Ian; Sowden, E; Orioli Figueira, Brigida (2016-04-22)

    Conference poster
    The University of Auckland Library

    This poster presents longitudinal data on the length and chapter composition of 800 doctoral theses deposited at the University of Auckland between 2008 and 2015. Over this period, the doctoral statute has been amended to allow for more flexibility in the format of a thesis submitted for examination, such as the inclusion of creative practice and peer-reviewed publications. In addition, the funding mechanisms for doctorates in New Zealand have put a premium on candidates completing in a timely fashion. Given these two contexts we speculated that the length of an average doctoral thesis would be declining over time. One hundred doctoral theses ??? overwhelmingly PhD theses with a smattering of name doctorates ???deposited in the University Library from each calendar year were randomly selected to assess: the number of pages; chapter composition; and inclusion of published papers within the thesis. These data were then correlated against academic faculty to tease out variations across the disciplines. Overall, our findings indicate that the doctoral thesis has remained relatively stable in length and chapter structure.

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  • Polyamine diamide orthidine F as a potent and selective antimalarial lead compound

    Liew, Lydia; Kaiser, M; Copp, B (2013)

    Conference poster
    The University of Auckland Library

    THE POLYAMINE DIAMIDE ORTHIDINE F AS A POTENT AND SELECTIVE ANTIMALARIAL LEAD COMPOUND Orthidine F (1) was isolated from an extract of the marine organism Aplidium orthium, found at Three Kings Islands, New Zealand.1 An initial screen of the natural product 1 against a panel of parasitic protozoa (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum K1 dual drug-resistant strain) identified selective inhibitory activity for T. brucei rhodesiense (IC50 78 ??M) against T. cruzi, no detectable activity towards L. donovani and moderate activity against P. falciparum. Furthermore, the natural product was found to be non-toxic in the non-malignant L6 rat myoblast cell line, thus representing an attractive target as an antiparasitic drug. A preliminary structure-activity relationship (SAR) study identified analogues with a similar activity profile to the natural product. The analogues were found to exhibit moderate inhibitory activity against T. brucei rhodesiense (IC50 3.2???210 ??M), more potent inhibitory activity against P. falciparum (IC50 0.0086???0.61 ??M), and no significant activity against T. cruzi and L. donovani. The analogues also continued to display little or no cytotoxic effect in the L6 cell line, this combined with the potent IC50 values obtained for inhibition of P. falciparum afforded a series of analogues with impressive properties which warranted further studies. This led to a second series of analogues with the intention of improving its antimalarial activity. The analogues generated from this exercise exhibited potent in vitro activities (IC50 0.0086???0.61 ??M) while retaining selectivity against P. falciparum. Three analogues were selected based on the in vitro data obtained and evaluated for in vivo activity in the Plasmodium berghei mouse model of malaria; which in this instance did not yield significant activity.

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  • fMRI Measures of the Dorsal Visual Cortex Correlates with Behavioral Performance and Cortical Thickness

    Poppe, Tanya; Leung, Myra; Tottman, Anna; Harding, Jane; Bloomfield, Francis; Alsweiler, Jane; Thompson, Benjamin (2015)

    Conference poster
    The University of Auckland Library

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  • Paternal depression during pregnancy and after childbirth: evidence from Growing Up in New Zealand

    Underwood, Lisa; Atatoa Carr, P; Berry, S; Grant, Cameron; Peterson, Elizabeth; Waldie, Karen; Morton, Susan (2016-07-06)

    Conference poster
    The University of Auckland Library

    Background: There is little evidence on depression among men whose partners are pregnant or have recently given birth. Methods: An ethnically and socioeconomically diverse sample of 3528 men living in New Zealand completed interviews during their partner's pregnancy and nine months after the birth of their child. Depression symptoms were measured using the Edinburgh Postnatal Depression Scale (EPDS) and the 9-item Patient Health Questionnaire (PHQ-9). Rates of depression (defined as EPDS>12 and PHQ-9>9) and associations with a range of paternal and maternal characteristics were explored using logistic regression. Results: Antenatal paternal depression, which affected 2.3% of fathers, was associated with paternal perceived stress (OR=1.4, 95%CI 1.3 to 1.5) and fair to poor paternal health (OR=2, 95%CI 1.1 to 3.5) during their partner's pregnancy. Postnatal paternal depression affected 4.3% of fathers and was associated with paternal perceived stress in pregnancy (OR=1.12, 95%CI 1.1 to 1.2), relationship status at nine months after childbirth (OR=5.6, 95%CI 2 to 15.7), fair to poor paternal health at nine months (OR=3.3, 95%CI 2 to 5.1), employment status at nine months (OR=1.8, 95%CI 1.1 to 3.1) and a past history of depression (OR=2.8, 95%CI 1.7 to 4.7). Conclusions: Expectant fathers are at risk of depression if they feel stressed or are in poor health. In this study, rates of depression were higher during the postpartum period and were associated with adverse social and relationship factors. Identifying who is most at-risk of paternal depression and when will help inform interventions to help men and their families.

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  • Who are Today's Dads?

    Underwood, Lisa; Atatoa Carr, P; Berry, S; Grant, Cameron; Kingi, TK; Pryor, J; Nicholson, J; Verbiest, Marjolein; Morton, Susan (2016-07-06)

    Conference poster
    The University of Auckland Library

    Dads play a crucial role in the lives of children. Who Are Today???s Dads? is a University of Auckland project related to the Growing Up in New Zealand study. We want to find out how dads shape their children???s early development, health and wellbeing. The ???dads??? of more than 5,000 6 year olds were invited to take part in an online questionnaire. We are interested in all ???dads??? not just those who are the biological fathers of their children but also step-dads, foster and/or adoptive parents, co-mums and other family members who fulfil a dad role. Another important focus of the study is the extent to which New Zealand children experience changes in ???dads???. We will explore the diversity of individuals who are father figures to contemporary New Zealand children with a focus on their work, parent???child relationship and how engaged dads are with their Growing Up in New Zealand child. Our aim is to determine how current and future policy can be developed to enhance the role that modern ???dads??? can play to contribute positively to children???s early development.

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  • Children who learn in more than one language in Aotearoa/New Zealand: New challenges and research processes

    Harvey, Nola; Podmore, Valerie; Hedges, Helen; Keegan, Peter; Mara, D; Lee, Jennifer; Tuafuti, P (2013-11)

    Conference poster
    The University of Auckland Library

    Demographic evidence indicates that learners in Aotearoa-New Zealand are increasingly likely to speak more than one language and that this is most evident in the Auckland region. These trends suggest emerging challenges for researchers and practitioners. This poster presents our TLRI* research, in progress, which documents the diversity of language use and experiences of children in early childhood education and care in the Auckland region. The collaborative research team includes University of Auckland researchers and teacherresearchers in four early childhood centres: a M??ori-medium centre, a Samoan immersion centre, and a kindergarten and a centre with children from a wide range of heritage language backgrounds. Theoretical frameworks influencing the design and analyses include an additive approach to bilingual activity and contexts that views children as potentially capable. The research (2013-2015) addresses three questions: 1. What languages do children from participating ECE centres use in their learning in the centre and at home? 2. What experiences and outcomes for children who learn in more than one language in the early years are valued by parents, teachers, and children? 3. How might the opportunities and challenges for children who learn in more than one language be addressed in educational practice? Objectives within each of the four partner-centre settings are to: ?? document the languages spoken by children, parents, and teachers in the ECE centre and at home ?? document and interpret the learning experiences of young children who learn in more than one language (as valued by parents, teachers, and children) ?? document the valued outcomes for young children who learn in more than one language ?? in partnership between teacher-researchers and University of Auckland researchers, analyse and theorise the data gathered, using funds of knowledge and additive bilingualism approaches, to build on understandings of the learning and teaching of children who learn in more than one language, and ?? analyse and theorise, using an 'additive approach' (to bilingualism, immersion, or multi-literacies), to extend understandings of the learning and teaching of children who learn in more than one language.) Research team members are using a range of qualitative and quantitative approaches to generate data about the experiences, opportunities, and challenges associated with learning in more than one language. Methods/tools include: questionnaires for parents and teachers, focus group interviews with parents and teachers, and fieldnote observations of arrivals and departures at the centres, videotaped observations of children's learning experiences in ECE settings, and conversations with children. In the poster session, aspects of these processes will be discussed. This research is significant, given the demographics and that there are gaps in current knowledge about learning experiences, valued outcomes and possible futures for children who are learning in more than one language in their ECE and (or) their family environments. Our study is designed to contribute new findings and to advance knowledge and practice about children learning in more than one language in the early years.

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  • Clinical prediction rules for appendicitis in adults: Which is best?

    Kularatna, M; Lauti, Melanie; Haran, C; MacFater, W; Sheikh, L; Huang, Y; McCall, J; MacCormick, Andrew (2017)

    Conference poster
    The University of Auckland Library

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  • Estado nutricional de los ind??genas Patax?? de 5 aldeas de Minas Gerais, Brasil (Nutritional status of the indigenopus Pataxo from Minas Gerias, Brazil).

    Gontijo de Castro, Teresa; Oliveira, SNLG; Mazzetti, CMS; Conde, WL; Leite, MS; Pimenta, AM (2012-11-13)

    Conference poster
    The University of Auckland Library

    Introducci??n: En las ??ltimas d??cadas los estudios brasile??os sobre el estado nutricional no incluyeron la poblaci??n ind??gena como un segmento de an??lisis, generando brechas de informaciones para el direccionamiento de pol??ticas de alimentaci??n y nutrici??n para el grupo. Objetivo: Evaluar el estado nutricional de los ind??genas Patax?? de 5 aldeas de Minas Gerais. Metodolog??a: Estudio transversal que evalu?? 257 ind??genas (87,4% del total) en 2011. El peso y la altura fueran evaluados conforme las orientaciones de la OMS. La circunferencia de la cintura (CC) fue tomada en el punto medio entre la cresta il??aca y la ??ltima costilla. Las clasificaciones nutricionales fueron hechas a partir de los ??ndices altura para edad (A/E), ??ndice de masa corporal para edad (IMC/E), ??ndice de masa corporal (IMC) y CC, utilizando las referencias de la OMS y de Lipschitz (para ancianos). Resultados: Fueron evaluados 70 ni??os (27,3%), 59 adolescentes (23,0%), 116 adultos (45,0%) y 12 ancianos (4,7 %). Ninguno de los ni??os present?? d??ficit para A/E, 1,4% presentaron bajo IMC/E y 2,9% peso elevado para IMC/E. Fue observado d??ficit de altura en 3,4% de los adolescentes y peso excesivo (IMC/E) en 8,5%. Altas prevalencias de sobrepeso/obesidad y valores elevados de CC fueron apuntados para adultos (56,0% y 56,8 %, respectivamente) y ancianos (25,0% y 75%, respectivamente). Conclusi??n: Se destacan el exceso de peso en la poblaci??n de forma ascendente desde la ni??ez y la baja frecuencia de d??ficits nutricionales entre ni??os y adolescentes. Financiaci??n: Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais.

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  • What???s on the INSIDE matters - exploring and characterising the 'Thin on the Outside Fat on the Inside' profile across ethnicities: the TOFI_Asia study

    Sequeira, Ivana; Yip, Wilson; Lu, Louise; Poppitt, Sally (2016-10-20)

    Conference poster
    The University of Auckland Library

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  • The STn-SNc hyperdirect pathway modulates dopaminergic neuron activity by inhibiting GABAergic inputs from the SNr via endocannabinoids

    Freestone, Peter; Wu, XH; de Guzman, G; Lipski, Janusz (2014-07-05)

    Conference poster
    The University of Auckland Library

    The hyperdirect pathway of the basal ganglia circuitry terminates with a glutamatergic projection from the Subthalamic Nucleus (STN) to the Substantia Nigra pars compacta (SNc). We recently showed that glutamate released in the SNc drives endocannabinoid production in dopaminergic neurons, which in turn inhibits GABAergic transmission in that region. The present study investigated the potential role of STN glutamatergic projections of the hyperdirect pathway in this novel endocannabinoid modulatory mechanism. Whole-cell patch-clamp recordings were made from SNc dopaminergic neurons in horizontal brain slices (rat) containing STN, SNc and Substantia Nigra pars reticulata (SNr) regions. Either electrical (bi-polar electrode) or pharmacological (local carbachol application) stimulation of the STN was performed to evoke selective glutamate release from terminals in the SNc. GABAergic inputs to the SNc from the SNr were electrically stimulated to evoke inhibitory post-synaptic currents (eIPSCs). Single-pulse electrical stimulation of the STN caused transient (< 1 sec) attenuation of GABAergic eIPSCs amplitudes recorded from dopaminergic neurons (to 73% of control). The eIPSC attenuation was prevented by block of either cannabinoid CB1 receptors with rimonabant (3 ??M) or metabotropic glutamate mGluR1 receptors with CPCCOEt (100 ??M). Pharmacological activation of STN neurons by rapid local perfusion of muscarinic agonist carbachol (100 ??M, 10 s) caused a similar attenuation of eIPSC amplitude. These findings show that glutamate release from STN terminals in the SNc modulates GABAergic transmission through endocannabinoid signalling ??? a previously undescribed function of the hyperdirect pathway.

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  • Recent experiences in using TOUGH2 for geothermal modelling

    Clearwater, Emily; Yeh, Angus; O'Sullivan, John; Kaya, Eylem; Croucher, Adrian; Cui, T; OSullivan, Michael; Zarrouk, Sadiq; Austria, JJC; Ciriaco, Anthony; Archer, Rosalind; Dempsey, David (2012-04-17)

    Conference poster
    The University of Auckland Library

    The geothermal modelling group in Engineering Science (University of Auckland) is involved with several geothermal R&D projects. On the development side we are running models of Ohaaki, Wairakei, Ngawha, Reporoa, Wayang Windu and Lihir. Our experiences in these projects have led on to several parallel research projects. Our model of Wairakei-Tauhara is so large that it also contains the Rotokawa system and the edge of the Ngatamriki system. Trying to understand the large-scale convection process at Wairakei-Tauhara has led on to studies of more generic convection studies and studies of larger areas of the TVZ. It has also led on to deeper models which require equations of state that can handle high pressures and temperatures. We have developed one for pure water but now wish to extend it to include CO2 and NaCl. With larger and larger models the computational demand increases quickly and we are now routinely using TOUGH_MP, the parallel version of TOUGH2. Also with large complex models dealing with input and output is a major task and we have developed a suite of PYTHON scripts (called pyTOUGH) for carrying out several model management tasks. One of the biggest challenges in geothermal modelling is model calibration and we have carried out studies using inverse modelling with iTOUGH and PEST and also Markov Chain Monte Carlo methods (MCMC). We are also carrying out miscellaneous studies of resewrvoir physics several of which involve fluid/rock interaction, for example the effects of cold water injection on permeability and subsidence in geothermal fields.

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  • PUKUmahi!: Kia whai te huarahi tika. NETwork! Roadmap for safe travel: Ensuring health benefits flow on to M??ori

    Henare, Kimiora; Parker, Kate; Print, Cristin; Findlay, Michael; Lawrence, Benjamin (2015-11-02)

    Conference poster
    The University of Auckland Library

    Neuroendocrine tumours (NET) are complex and variable, making it very difficult for clinicians to determine the best course of treatment. The NETwork project seeks to better understand the epidemiological impact of NETs in New Zealand, and to better characterise the disease to help inform oncologists how to treat it. The estimated incidence rate of patients with NETs in New Zealand is approximately 200 patients per year, however the impact among M??ori is not yet known. M??ori are disproportionately burdened by cancers of the lungs, stomach, and pancreas, so it is tempting to speculate that NET incidence among M??ori could also be high. It is essential that M??ori are involved in the study in order to get an accurate indication of the impact of this cancer in New Zealand, what genes are driving the cancers, and how each can be treated. The multi-faceted NETwork project combines epidemiological analysis and deep genome sequencing of retrospective and prospective NET tissues. Under the guidelines set out in Te Ara Tika, the design of this research project is mainstream, but is likely to involve M??ori participants and have direct relevance to M??ori. Despite being neither M??ori-centred nor Kaupapa M??ori in our approach, the NETwork team are dedicated to honouring the Treaty of Waitangi principles of partnership, participation, and protection. Mindful of the past transgressions involving the use of tissues and genetic information obtained from indigenous populations here in New Zealand and overseas, the NETwork group are keen not to repeat these errors themselves, nor facilitate the opportunity for others to do so. Following ongoing consultation with Te Mata Ira, Maui Hudson, Dr Helen Wihongi, and Associate Professor Papaarangi Reid, we have established a ???roadmap for safe travel??? to guide all aspects of the multi-faceted project. The framework has three key principles (kawa) underpinning its Governance structure, and three core cultural protocols (tikanga) to be incorporated into the implementation strategies. Adhering to these kawa and tikanga should facilitate the establishment and maintenance of relationships with key stakeholders; a vital aspect to the project. The roadmap for safe travel is still in its early stages of development, and consultation is ongoing. Nevertheless, the NETwork team have a strong platform from which to further develop their project. Although the presented framework is specific to the NETwork project, it could easily be adjusted and utilised for other clinical and biomedical projects.

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  • Who are Today's Dads?

    Underwood, Lisa; Atatoa Carr, P; Berry, S; Grant, Cameron; Morton, Susan (2015-12-14)

    Conference poster
    The University of Auckland Library

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  • Reducing the Risks of Long-Term Human Space Exploration by Simulating Missions in an Analog Environment on Mauna Loa

    Binsted, K; Hunter, JB; Caldwell, Bryan (2012-02)

    Conference poster
    The University of Auckland Library

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