266 results for Conference poster

  • The Effect of Glycosylation on the Potency of Pramlintide, An Anti-Diabetic Drug

    Fletcher, Madeleine; Kowalczyk, Renata; Fairbanks, A; Brimble, Margaret; Hay, DL (2013-12-18)

    Conference poster
    The University of Auckland Library

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  • Over-expression of Human Amylin Leads to Oligomerization and beta-cell Dysfunction Associated with Mitochondrial Uncoupling, Activation of c-Jun and Decrease Expression of JNK Interacting Protein-1

    Zhang, Shaoping; Liu, H; Chuang, CL; Li, XL; Au, M; Zhang, L; Cooper, GJS (2012-06-10)

    Conference poster
    The University of Auckland Library

    Over-expression of human amylin (hA) in pancreatic β-cells has been shown to contribute to cytotoxic hA aggregation and islet amyloid formation that can lead to β-cell dysfunction in type-2 diabetes mellitus. We aimed to investigate the functional and molecular changes associated with hA oligomer formation and their relation to β-cell dysfunction and diabetes development using transgenic mouse model that over-expresses hA in their islet β-cells.We showed that both homozygous and hemizygous hA transgenic mice developed spontaneous diabetes with different elevated levels of hA and with different time frame of disease onset and death. Homozygous mice displayed hyperinsulinemia and self-limiting insulin resistance during the pre-diabetic state, whereas by contrast, hemizygous mice had a longer prediabetic phase without insulin resistance. Intracellular and extracellular oligomers were clearly detectable before onset of diabetes with strong correlation with the time of β-cell apoptosis occurred in homozygous but not in hemizygous mice, indicating a difference in the extent of cytotoxic oligomerization between these animals. In addition, RT-qPCR analysis demonstrated progressive decrease in β-cell expression of functional and key regulatory molecules such as insulin, amylin, Pdx1, MafA, Glut2 and GCK. We also detected changes in expression of the mitochondrial membrane protein UCP-2 which contributes to decreased mitochondrial function. Further molecular analysis demonstrated activation of c-Jun/JNK and decrease expression of JNK-interacting protein 1, suggesting their role in mediating beta-cell death/apoptosis. Our studies should lead to a better understanding of the role and regulation of hA-evoked β-cell dysfunction and β-cell death in diabetes

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  • The role of conspicuity in bicycle crashes involving a motor vehicle

    Tin Tin, Sandar; Woodward, Alistair; Ameratunga, Shanthi (2014-10-30)

    Conference poster
    The University of Auckland Library

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  • The development of a whey-based kefir beverage: Physiocochemical, sensory and microbiological characteristics

    Chan, Cheuk; Quek, Siew-Young; Roberton, AM (2007-11-15)

    Conference poster
    The University of Auckland Library

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  • Nano-structural organisation in ionic liquids

    Kathirgamanathan, Kalyani; Al-Hakkak, J; Edmonds, Neil; Easteal, Allan; Grigsby, WJ (2009-12-09)

    Conference poster
    The University of Auckland Library

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  • Monitoring the health of New Zealand’s young people: A decade of surveillance research

    Clark, TC; Fleming, T; Bullen, P; Crengle, S; Denny, S; Dyson, B; Peiris John, R; Robinson, E; Rossen, F; Sheridan, J; Teevale, T; Utter, J; Fortune, S; Lewycka, S (2013)

    Conference poster
    The University of Auckland Library

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  • Purine Nucleosides as Cholinesterase Inhibitors

    Marcelo, F; Rauter, AP; Blériot, Y; Sinaÿ, P; Oliveira, Maria; Goulart, M; Justino, J (2008-09)

    Conference poster
    The University of Auckland Library

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  • Identification of a lead hypoxia-activated irreversible pan-HER inhibitor SN32807 (PR509) by pharmacokinetic and anti-tumor efficacy screening in an erlotinib-resistant xenograft model

    Jaiswal, Jagdish; Lu, Guo-Liang; Jamieson, S; Lee, Ho; Abbattista, Maria; Anderson, BF; Ashoorzadeh, Amir; Denny, William; Doñate, F; Hsu, HL; Maroz, A; Pruijn, A; Puryer, M; Thompson, Aaron; Wilson, William; Smaill, Jeffrey; Patterson, Adam (2011-10-23)

    Conference poster
    The University of Auckland Library

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  • High Pressure and Thermal Processing of kiwifruit puree: the effect on antioxidants and vitamin C

    Soloman, N; Oliveira, Maria (2011-11-30)

    Conference poster
    The University of Auckland Library

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  • Giving research global reach: ResearchSpace@Auckland

    Newton-Wade, Vanessa; Hayes, Leonie (2008)

    Conference poster
    The University of Auckland Library

    A key part of the academic research process is publishing the results – ‘getting it out there’. An institutional repository such as ResearchSpace@Auckland provides authors with a channel for near-instantaneous worldwide dissemination of research. ResearchSpace@Auckland at the University of Auckland was initially developed under the umbrella of the Institutional Repositories Aotearoa (Ira) Project. The project between Auckland, Canterbury and Victoria Universities used DSpace Open Source Software and was funded by the Tertiary Education Commission (TEC). The project was completed in 2007. ResearchSpace is now a full production system with seamless Disaster Recovery ability, which allows authors to submit their work confident that it will be secure. ResearchSpace contains ‘research outputs’ from the University of Auckland’s staff and students, including theses, papers and reports. From 2007 it is a requirement for all enrolling PhD students to submit a digital copy of their thesis upon completion. The PhD collection has grown from an initial 200 items at the beginning of 2007 to nearly 1700 items. 775 of these are open-access. This has been achieved via a retrospective digitization project for all PhD theses and a campaign to contact the authors for permission. Key features of ResearchSpace • Authors submit their own content initially (self-submission), administrators check content and publish it online • Most content is freely available to any user – use is not restricted to members of the institution or subscribers • Durable & Permanent URLs: we use ‘Handles’. e.g. http://hdl.handle.net/2292/1430. A handle does not have the institution’s domain name in the URL, if the website is changed or moved, the URL will still go to the correct location. • Preservation: creating digital files allows creation of a new print copy if necessary. Thesis files are in Portable Document Format (PDF), and the library has undertaken to keep the formats up to date, as technology may change in the future.

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  • Metabolic Outcomes in children born to mothers with severe hyperemesis gravidarum

    Ayyavoo, A; Hofman, Paul; Derraik, J; Mathai, M; Stone, P; Bloomfield, F; Cutfield, C (2012-06-23)

    Conference poster
    The University of Auckland Library

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  • Etiology of increasing incidence of congenital hypothyroidism in New Zealand from 1993 to 2010

    Albert, B; Jefferies, C; Webster, D; Cutfield, W; Gunn, A; Carll, J; Bendikson, K; Derraik, J; Hofman, Paul (2012-06-24)

    Conference poster
    The University of Auckland Library

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  • New sugar agents for the control of undesirable microbes in the food industry

    Oliveira, Maria; Justino, J; Neves, A; Rauter, AP (2007-11-14)

    Conference poster
    The University of Auckland Library

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  • Purine nucleosides as new agents for the control of Alzheimer’s disease

    Oliveira, Maria; Marcelo, F; Justino, J; Jacob, AP; Bleriot, Y; Sinay, P; Goulart, M; Rauter, AP (2009-01-20)

    Conference poster
    The University of Auckland Library

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  • Stream Restoration: Getting the microbial ecology right.

    Lewis, Gillian; Lear, Gavin; Turner, Susan; Boothroyd, Ian; Stott, Rebecca; Roberts, Kelly; Ancion, Pierre; Dopheide, Andrew; Washington, Vidya; Knight, Duane; Smith, Joanna (2008-08-17)

    Conference poster
    The University of Auckland Library

    A comprehensive program to re-establish the structure and function of an ecosystem, including its natural diversity and aquatic habitats.

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  • Ciliate Diversity in Stream Biofilms revealed by group-specific PCR primers.

    Dopheide, Andrew; Lear, Gavin; Stott, R; Lewis, Gillian (2008-08-17)

    Conference poster
    The University of Auckland Library

    The ciliates are a diverse protozoan phylum, thought to be of considerable ecological importance in stream ecosystems, including organisms which are abundant and important consumers of bacteria, algae and other protozoa. Understanding of ciliate diversity and ecology is limited, however, particularly in benthic habitats such as stream biofilms. In this study, phylum-specific PCR primers were used in combination with cloning, sequencing and terminal restriction fragment length polymorphism (T-RFLP) analysis to investigate ciliate communities in stream biofilms.

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  • Metabolomics as a novel approach to study mixed species biofilms of stream bacteria exhibiting mutualistic and antagonistic responses

    Washington, Vidya; Villas-Boas, Silas; Lewis, Gillian (2008-08-17)

    Conference poster
    The University of Auckland Library

    Experimental objective / Purpose 1. To investigate the metabolic interactions of bacterial species using metabolic footprint profiling. 2. As proof of concept, microbes exhibiting mutualistic and antagonistic associations were chosen for this study.

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  • Getting Research 'Out There': ResearchSpace@Auckland

    Newton-Wade, Vanessa; Laurie, John; Hayes, Leonie (2007)

    Conference poster
    The University of Auckland Library

    A key part of the academic research process is publishing the results – ‘getting it out there’. An institutional repository such as ResearchSpace@Auckland provides authors with a channel for near-instantaneous worldwide dissemination of research. ResearchSpace@Auckland has been developed at the University of Auckland under the umbrella of the Institutional Repositories Aotearoa Project (Ira). Built using DSpace Open Source Software, the repository contains ‘research outputs’ from the University of Auckland’s staff and students, including theses, papers and reports. The PhD thesis collection is the flagship of the repository – electronic submission is compulsory for all completing PhD students from 2011. The initial 200 items in the PhD thesis collection were gathered by contacting authors of theses submitted at the University of Auckland since 2001 and inviting them to submit digital copies and consent forms. Trials are underway to digitize theses that are unavailable in digital format. The mandating of compulsory submission for PhD theses submitted at the University of Auckland ensures regulatory requirements for digital deposit are catered for. Other collections for articles, papers, and images are being developed.

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  • Registry of BioBricks models using CellML

    Rouilly, Vincent; Canton, Barry; Nielsen, Poul; Kitney, Richard (2007)

    Conference poster
    The University of Auckland Library

    An open access copy of this article is available and complies with the copyright holder/publisher conditions. One of the main goals in Synthetic Biology is to assess the feasibility of building novel biological systems from interchangeable and standardized parts. In order to collect and share parts, a Registry of standardized DNA BioBricks http://parts.mit.edu/registry has been established at the MIT. BioBricks can be assembled to form devices and systems to operate in living cells. Design of reliable devices and systems would benefit from accurate models of system function. To predict the function of systems built from many parts, we need to have accurate models for the parts and mechanisms to easily compose those part models into a system model. Therefore, in parallel to increasing the number of parts available and characterising them experimentally, a logical extension to the Registry would be to build a Registry of BioBrick models to complement the physical parts.

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  • Space-Time Multi-Resolution Banded Graph-Cut for Fast Segmentation. (Conference Poster)

    Vaudrey, Tobi; Gruber, Daniel; Wedel, Andreas; Klappstein, Jens (2008)

    Conference poster
    The University of Auckland Library

    Conference Details: 30th Annual Symposium of the German Association for Pattern Recognition DAGM Munich, Germany, June 2008. http://www.dagm2008.org/ Applying real-time segmentation is a major issue when processing every frame of image sequences. In this paper, we propose a modi cation of the well known graph-cut algorithm to improve speed for discrete segmentation. Our algorithm yields real-time segmentation, using graph-cut, by performing a single cut on an image with regions of di erent resolutions, combining space-time pyramids and narrow bands. This is especially suitable for image sequences, as segment borders in one image are re ned in the next image. The fast computation time allows one to use information contained in every image frame of an input image stream at 20 Hz, on a standard PC. The algorithm is applied to traf- c scenes, using a monocular camera installed in a moving vehicle. Our results show the segmentation of moving objects with similar results to standard graph-cut, but with improved speed.

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