277 results for Conference poster

  • Buried Faults in the Auckland Region

    Gasston, Caleb; Lindsay, Jan; Brook, MS (2016-12-09)

    Conference poster
    The University of Auckland Library

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  • Three-Dimensional Structural Characterization of Tissue Engineered and Native Ovine Pulmonary Valves

    Eckert, Chad; Gerneke, Dane; Le Grice, Ian; Gottlieb, David; Mayer, JE; Sacks, MS (2009-04)

    Conference poster
    The University of Auckland Library

    OBJECTIVES: Efforts in tissue-engineered heart valves (TEHV) have shown increasingly equivalent mechanical/structural properties compared to native valves, though a literature gap exists regarding detailed structural information. This work was performed to provide such data of implanted TEHV, the native pulmonary valve (PV), and pre-implant scaffold to better understand developing TEHV. METHODS: Dynamically-cultured in vivo samples (???pre-implant???) and ovine TEHV PV in vitro samples (???explant???) were produced based on previous techniques; ovine PVs were excised. Samples were stained with picrosirius red and resinmounted. Using extended-volume scanning laser confocal microscopy (EV-SLCM), 1.5 x 1.5 x 0.4 mm full-thickness samples were imaged at 1 pixel/??m in 1 ??m Z-direction steps. Custom software was used to process and visualize samples. Collagen, cell nuclei, and scaffold volume fractions were quantified; scaffold fiber trajectory and length were tracked using custom software. RESULTS: In a scaffold representative volume (90 ??m thick), 104 fibers were tracked with a mean fiber length of 137.94 ??m 55.4 ??m (Fig.1). A comparison between pre-implant and explant samples showed collagen volume fraction increasing from 76.6% to 85.9%, with nuclei and scaffold decreasing from 2.8% to 0.5% and from 5.9% to 0.8%, respectively. With the native collagen volume fraction measured at 70%, pre-implant and explant samples showed an increase in collagen. CONCLUSIONS: This work captured important differences between in vivo/in vitro TEHV constituents; it is the first known work to utilize EV-SLCM on TEHV. A comparison to the native valve showed structural differences that could impact longterm functionality and improve design.

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  • Progress Testing: Two Countries Divided by a Common Language

    O'Connor, Barbara; Lillis, Steven; Weston, Kimberley; Freeman, A; Bagg, Warwick (2014)

    Conference poster
    The University of Auckland Library

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  • The role of conspicuity in bicycle crashes involving a motor vehicle

    Tin Tin, Sandar; Woodward, Alistair; Ameratunga, Shanthi (2014-10-30)

    Conference poster
    The University of Auckland Library

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  • Using network science to explore innovation

    O'Neale, DR; Hendy, SH (2013-06-06)

    Conference poster
    The University of Auckland Library

    We live in a world were scientific and technical advances require increasingly specialised knowledge while drawing expertise from ever more diverse technical areas. In an effort to better understand the relationships between different areas of innovation, and the role of specialisation, diversity and ubiquity in national and regional economies, we have mined several million patent records from the European Patent Office, along with their classification codes, and used them to construct a network of ???patent-space???. Patents provide a rich data set when studying innovation. Networks of scientific publications, such as that in [1], formed from inter-journal citations, illustrate the links between different disciplines as new knowledge is created, while networks of countries and the goods they export, such as the ???product-space??? network in [2], give insight into the economic complexity (or otherwise) and the likely areas of growth for national economies. Using patents allows us to take an intermediate view and investigate the role of science and innovation in economic growth. We take an approach similar to [2], identifying when individual countries or geographic regions have a ???revealed comparative advantage??? with respect to particular technical areas. We have constructed a proximity network as a base-map for the space of patentable innovation. We find that patent-space is heterogeneous and highly structured, and that the structure depends on the size or ???granularity??? of the regions that data is aggregated into. By overlaying data for particular regions on the patent-space base map we are able to explore temporal and regional trends ??? in particular how the innovation systems of different countries has produced quite different areas of specialisation. Figure 1: Patent-space for New Zealand (left) and South Korea (right) - two countries with very different innovation systems. Nodes represent patent classification classes. Nodes are dark when the country has a comparative advantage in that area and faded out otherwise. Nodes are connected if a comparative advantage with respect to one classification tends to occur in conjunction with a connected classification. [1] L. Leydesdorff & I. Rafols, Journal of the American Society for Information Science and Technology (2008). [2] C. Hidalgo & R. Hausmann, Proceedings of the National Academy of Sciences (2009).

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  • Searching for anomalous light curves in massive data sets

    Rattenbury, Nicholas (2014-01-19)

    Conference poster
    The University of Auckland Library

    The photometric surveys currently under way by the MOA and OGLE collaborations have produced and are extending databases of millions of stellar light curves. These databases have allowed investigations into diverse astrophysical fields including variable stars, proper motion studies and Galactic structure. Odd, or otherwise curious events have been discovered in the databases. We consider here one such event and propose methods for discovering more like it in the microlensing databases. A further aim of this initial work is to set out the prospects of the classification scheme for identifying time series that are maximally discordant - i.e. those that do not look like any other time series in the data set, and which therefore, may be of particular interest.

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  • What influences the association between previous and future crashes among cyclists.

    Tin Tin, Sandar; Woodward, Alistair; Ameratunga, Shanthi (2014-10-09)

    Conference poster
    The University of Auckland Library

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  • Sick unto death: Barriers and facilitators to M??ori access to primary care in New Zealand

    Reid, Jennifer (2013-04-16)

    Conference poster
    The University of Auckland Library

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  • Mid-term results after phaco-canaloplasty and canaloplasty

    Hurtikova, KH; Traine, PT; Loertscher, Martin; Mueller, MM (2015-06-06)

    Conference poster
    The University of Auckland Library

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  • Characterisation of a transgenic ovine model of Huntington???s disease

    Reid, Susanne; Handley, R; Patassini, S; Rudiger, S; Keynes, P; McLaughlan, C; Waldvogel, H; Jacobsen, J; MacDonald, M; Gusella, J; Morton, J; Bawden, S; Faull, R; Snell, R (2011-09-11)

    Conference poster
    The University of Auckland Library

    A transgenic ovine model of Huntington???s disease has been developed to enable the examination of the earliest disease changes in a large mammal. Ovis aries were selected because their basal ganglia and cortex is similar to analogous regions of the human brain. Importantly, they live for more than a decade, allowing for the study of the chronic effects of a fulllength HTT expressing transgene. Microinjection of a fulllength human HD cDNA containing 73 polyglutamine repeats under the control of the human promoter, resulted in six transgenic founders varying in copy-number of the transgene.

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  • Talking Allowed!

    Davies, Maree; Sinclair, A (2011)

    Conference poster
    The University of Auckland Library

    Research on the Paideia Method (a method for discussing a topic) was conducted in 20 classrooms across five schools, of varying socioeconomic environments (ages 11-13) in Auckland, New Zealand, in 2010. The researchers sought to further examine the results from their pilot study of the Paideia Seminar, entitled 'Talking Allowed: I like it when the teacher lets us talk without telling us what to say', trialed in 2008 (Sinclair & Davies, 2011). In addition, in order to provide the optimum conditions to prepare the students for the face-to-face seminars, an online component (open source software) was added as an alternative medium to assist students in their preparation. The research questions were: What happens to the Nature of Interaction, and the Complexity of the Discussion when students participate in a Paideia Seminar, and an on-line discussion in preparation for the face-to-face seminar? What is the optimal role of the teacher when participating in a Paideia Seminar and an on-line discussion to increase complexity of discussion?

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  • Condicoes de saude dos indigenas menores de 5 anos Pataxo, MG, Brasil. Health conditions of the under 5 years old indigenous Pataxo children, MG, Brazil

    Santos, AP; Leite, MS; Conde, WL; Franco, MCP; Gontijo de Castro, Teresa (2016-10-29)

    Conference poster
    The University of Auckland Library

    Introdu????o: O quadro de sa??de dos povos ind??genas no Brasil ?? complexo e din??mico, est?? relacionado ao processo hist??rico de mudan??as econ??micas, sociais e ambientais (Santos & Coimbra Jr., 2003). Altas preval??ncias de d??ficit estatural (25,7%) tem acometido as crian??as ind??genas brasileiras e diarreia e infec????o respirat??ria aguda sao apontadas como as maiores causas de interna????o hospitalar notificada (Horta et al., 2013; Leite et al., 2013; Coimbra et al., 2013). Objetivo: Dentre os menores de 5 anos Pataxo de Minas Gerais: 1) descrever caracter??sticas de nascimento, situa????o vacinal, acompanhamento do pre-natal e do crescimento e desenvolvimento, perfil de morbidades e acessos aos servi??os de sa??de; 2) verificar associacoes entre estado nutricional e condicoes de saude observadas. Metodologia: Estudo epidemiol??gico de base populacional, natureza transversal, com dados coletados em 2011 entre os Patax?? de Minas Gerais. Foram avaliadas 34 crian??as (< 5 anos) residentes em 5 aldeias do povo Patax??, localizadas nos munic??pio de Carm??sia, Itapecerica e A??ucena. A avalia????o da situa????o de sa??de utilizou question??rio estruturado baseado no Primeiro Inqu??rito Nacional de Sa??de e Nutri????o dos Povos Ind??genas (Cardoso et al., 2009). A aferi????o das medidas antropom??tricas (peso, estatura/comprimento e circunfer??ncia da cintura) foi realizada de acordo com as recomenda????es da Organiza????o Mundial da Sa??de. O presente estudo foi aprovado pelo comit?? de ??tica da Universidade Federal de S??o Paulo pela Comiss??o Nacional de ??tica em Pesquisa. Foram calculadas freq????ncias de vari??veis categ??ricas e m??dias (desvios-padr??o) e medianas das vari??veis cont??nuas. Para a identifica????o de diferen??as entre as m??dias utilizou o teste t de Student, enquanto propor????es foram comparadas pelo teste do qui-quadrado de Pearson, adotando-se P< 0,05. Utilizou-se o programa SPSS (17.0) para analise dos dados. Resultados: Entre os menores de 5 anos, 55,9% eram do sexo feminino e 44,1% tinham idade inferior a 24 meses. A maioria das crian??as nasceu no hospital, e 82,4% das maes tiveram 6 ou mais consultas de pre-natal. Mais de 80% das mesmas estavam com o esquema vacinal em dia a ??poca da pesquisa e havia tomado a megadose de vitamina A. Apenas 8,8% das crian??as tinham o registro do acompanhamento do crescimento no ??ltimo m??s anterior a pesquisa. A preval??ncia de hospitaliza????o nos ??ltimos 12 meses foi de 23,5%, mas nenhuma interna????o foi devida a infec????es respirat??rias e apenas uma crian??a foi internada com diarreia. Ocorr??ncia de diarreia na ??ltima semana foi relatada para 17,6% das crian??as e tosse para 35,3%. Devido ao fato dos d??ficits estaturais e ponderais serem inexistentes nesta popula????o e o excesso de peso ter acometido somente uma das crian??as, n??o foi poss??vel verificar a distribui????o dos dist??rbios nutricionais de acordo com as vari??veis independentes, de forma a verificar-se poss??veis associa????es. Conclus??es: Comparado com a populacao de criancas indigenas brasileiras, alguns indicadores de saude entre os Pataxo tiveram melhor desempenho, como a baixa preval??ncia de interna????o hospitalar reportada para diarreia e IRAs, a alta cobertura vacinal e o percentual de gestantes que tiverm 6 ou mais consultas pre-natal. No entanto, melhorias na periodicidade de acompanhamento do crescimento e desenvolvimento sao necessarias.

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  • Preclinical rationale for the ongoing Phase 2 study of the hypoxia-activated EGFR-TKI tarloxotinib bromide (TH-4000) in patients with advanced squamous cell carcinoma of the head and neck (SCCHN) or skin (SCCS).

    Jackson, V; Silva, S; Abbattista, Maria; Guise, Christopher; Bull, Matthew; Ashoorzadeh, Amir; Hart, C; Pearce, T; Smaill, Jeffrey; Patterson, Adam (2015)

    Conference poster
    The University of Auckland Library

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  • Clinical prediction rules for appendicitis in adults: Which is best?

    Kularatna, M; Lauti, Melanie; Haran, C; MacFater, W; Sheikh, L; Huang, Y; McCall, J; MacCormick, Andrew (2017)

    Conference poster
    The University of Auckland Library

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  • What is the host range of Phytophthora agathidicida in New Zealand

    Ryder, Jessica; Burns, Bruce (2016-08-08)

    Conference poster
    The University of Auckland Library

    hytophthora agathidicida is a virulent oomycete plant pathogen, which is currently known to only infect Agathis australis in New Zealand. Phytophthora species rarely have a single plant host, so other hosts for P. agathidicida are likely but unknown. Phytophthora species are also often cryptic and sometimes asymptomatic on their host plants, making it a challenge to identify their true host range. Once an exotic Phytophthora species is introduced to an area, it becomes virtually impossible to eliminate. A sound understanding of a Phytophthora???s epidemiology is needed to prevent its spread onto uninfected hosts. This study determined whether P. agathidicida has a wider host range than currently recognised. Plant community composition was compared between healthy and infected kauri forest to detect possible susceptible species, and detached leaf assays were utilised as a further screen of possible hosts. Results showed a significant difference in species abundances between sites infected with P. agathidicida and sites without P. agathidicida that was unrelated to other potential variables. Leaf assays also indicated several other native plant species other than A.australis as possible carriers or hosts, including Knightia excelsa and Leucopogon fasciculatus. Identifying the host range of P. agathidicida is important for optimising the design of future control strategies for this pathogen.

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  • Multi-Scale and Multi-Physics Visualization

    Blackett, Shane; Bullivant, D; Nickerson, David; Hunter, Peter (2005-07-31)

    Conference poster
    The University of Auckland Library

    Accurate computational models of physiology require the coupling of different physical processes that occur across a wide range of spatial scales. The interpretation and analysis of the calculated results of these models require the integrated visualization of these multi-scale and multi-physics processes. A number of different strategies for doing this are presented for a model of the heart left ventricle.

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  • Urea cycle enzymes and peptidylarginine deiminase in Alzheimer's superior frontal gyrus

    Cicolini, J; Jing, Y; Waldvogel, Henry; Faull, Richard; Liu, P (2016-07-24)

    Conference poster
    The University of Auckland Library

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  • The spirit that is one's own: A conversation in two tongues, Ko te wairua n?? te tangata ake: He whakawhitiwhiti k??rerorero ki roto i ng?? reo e rua

    Dattaray, D; Keegan, Peter (2016-11-17)

    Conference poster
    The University of Auckland Library

    Indigenous epistemes and philosophies help one understand ethical responsibilities in a changing world, between knowing and learning. Aesthetic, socio-political, cultural and normative aspects of human existence are reflected in Indigenous narrative traditions and language practices. This paper attempts to forge connections between the historical and discursive Indigenous practices of M??ori of New Zealand and Karbis from the North East of India. M??ori are the only indigenous group in New Zealand. M??ori are now highly urbanized, in a largely English speaking and Western dominated context, yet have made important gains in language and cultural revitalization. The North East of India today is a profound paradox that simultaneously represents the frontiers of globalization as well as a heritage of Indigenous traditions and cultures. In present-day India, the ???North East??? often denotes a sense of geographical isolation and is perceived as a region of ethnic strife and violence. North East is also a treasure trove of culture and tradition belonging to hundreds of Indigenous communities from the region. Through an interdisciplinary dialogue, the paper attempts a rethink on issues of public accessibility, intellectual and cultural property rights. Further, it underlines the significance of reciprocal education and training in the context of Indigeneity.

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  • Population Pharmacokinetics of Ethanol in Moderate and Heavy Drinkers

    Jiang, Y; Holford, Nicholas; Murry, DJ; Brown, TL; Milavetz, G (2015-10-07)

    Conference poster
    The University of Auckland Library

    Objectives: To investigate the effect of sex, age, and previous drinking history on ethanol pharmacokinetic parameters with the implementation of a rate dependent extraction model [1], which takes into account the change in hepatic first-pass extraction along with absorption rate and a body composition model that accounts for fat free mass and fat mass [2]. Methods: 108 moderate or heavy drinkers were dosed orally on 2 occasions to achieve a peak blood ethanol concentration of 0.65 g/L or 1.15 g/L using a randomized, crossover design. A total of 6025 breath measurements were obtained and converted into blood alcohol concentration by applying a blood: breath ratio of 2100:1. NONMEM 7.3.0 was used for data analysis. A semi-mechanistic rate dependent extraction model with zero-order input followed by first order absorption was utilized with V allometrically scaled by normal fat mass, Vmax allometrically scaled by total body weight and portal vein blood flow allometrically scaled by fat free mass. The effects of sex and age (21???34, 38???51, or 55???68 years of age) on V, Vmax, and Km; and the effect of drinking status (moderate or heavy drinkers) on Vmax and Km were explored. The covariate effect was considered to be statistically significant if the 95 % non-parametric bootstrap confidence interval of the fractional difference did not include 1. Results: The 95 % bootstrap confidence interval of fractional differences between groups in age, sex and ethanol consumption history all contain 1, indicating none of those covariates have significant effects on any ethanol disposition parameters. Conclusions: Age and sex were not regarded as significant predictors for ethanol disposition parameters after accounting for body size and composition. The results indicated a 19 % higher Vmax and 15 % lower Km for heavy drinkers compared with moderate drinkers, but the difference was not statistically significant.

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  • Identification of a novel group of muscular dystrophies, the Anoctaminopathies, caused by recessive mutations in the putative calcium activated chloride channel, ANO5

    Marlow, Gareth; Bolduc, V; Boycott, KM; Saleki, K; Inoue, H; Kroon, J; Itakura, M; Robitaille, Y; Parent, L; Baas, F; Mizuta, K; Kamata, N; Richard, I; Linssen, W; Mahjneh, I; de Visser, M; Brais, B; Bashir, R (2010-03-01)

    Conference poster
    The University of Auckland Library

    The Anoctamin (ANO) family consists of 10 proteins several of which have been shown to correspond to the elusive calciumactivated chloride channels (CaCCs). CaCCs are gated by increases in intracellular calcium and they have been linked to several cellular functions including epithelial transport, cell volume regulation, olfactory and photoreceptor transduction, cardiac membrane excitability, and smooth muscle contraction. The only reported human mutations linked with the ANO family are dominant mutations in ANO5, which cause a rare bone fragility disorder gnathodiaphyseal dysplasia (GDD1). Recently we have identified recessive ANO5 mutations in patients with proximal limb girdle muscular dystrophy (LGMD2L) and a distal non-dysferlin Miyoshi myopathy (MMD3). The mutations identified consist of splice site, a single adenine duplication and missense. The duplicated adenine is present in LGMD2L and MMD3. The LGMD2L phenotype is characterized by proximal muscle weakness and prominent asymmetric quadriceps atrophy. The MMD3 phenotype is associated with distal weakness in particular of the calf muscles. The clinical heterogeneity associated with ANO5 mutations is reminiscent of that observed with dysferlin mutations which can cause both a LGMD and distal muscular dystrophy. ANO5 mutations are associated with loss of muscle membrane integrity and defective membrane repair. Our studies suggest that ANO5 is a putative calcium-activated chloride channel which may function with dysferlin in membrane repair. Our study has identified a novel group of muscular dystrophies ???the Anoctaminopathies???.

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