6 results for Patent, 2014

  • Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy

    Rewcastle, Gordon; Gamage, Swarnalatha; Flanagan, JU; Giddens, Anna; Tsang, KY (2014-07-08)

    Patent
    The University of Auckland Library

    Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

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  • Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system

    Hunter, IW; Taberner, Andrew; Hogan, NC (2014-09-02)

    Patent
    The University of Auckland Library

    A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.

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  • Injection methods using a servo-controlled needle-free injector

    Hemond, BD; Hunter, IW; Taberner, Andrew; Wendell, DM; Hogan, NC (2014-06-03)

    Patent
    The University of Auckland Library

    A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2014-07-15)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Needle-free injector device with autoloading capability

    Hunter, IW; Hemond, BD; Wendell, DM; Hogan, NC; Taberner, Andrew; Ball, NB (2014-03-25)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

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  • Heat Exchanger

    Taylor, Mark; Chen, John; Farid, M; Wallace, RJ (2014-07-15)

    Patent
    The University of Auckland Library

    A heat exchanger 10 includes a conduit 12 for conveying cooling fluid relative to a body to be cooled. A heat transfer arrangement 62 is arranged in communication with an interior of the conduit 12, the heat transfer arrangement 62 and the conduit 12 together defining an assembly that is mountable adjacent the body to be cooled, convective heat exchange occurring, in use, due to movement of the cooling fluid relative to the body and to the heat transfer arrangement 62 of the assembly and radiant heat exchange occurring between the body and at least part of the heat transfer arrangement 62 of the assembly.

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