79 results for Patent

  • Microscopic dynamic mechanical analyzer

    Garcia-Webb, MW; Hunter, IW; Taberner, Andrew (2009)

    Patent
    The University of Auckland Library

    An electromagnetic apparatus, comprises a conductive loop comprising two parallel conductive legs joined at a free end by a sample contacting member and a magnetic circuit that imposes a magnetic field in opposite directions across the respective legs. A method of mechanically characterizing a sample, comprises imposing a magnetic field in opposite directions in each of two parallel conductive legs of a conductive loop, the legs joined at a free end by a sample contacting member.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC

    Patent
    The University of Auckland Library

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  • Cascaded Raman Laser

    Martinelli, C; Leplingard, F; Sylvestre, T; Vanholsbeeck, Frederique; Emplit, P (2006-02-07)

    Patent
    The University of Auckland Library

    A cascaded Raman laser (10) has a pump radiation source (12) emitting at a pump wavelength λp, an input section (14) and an output section (16) made of an optical medium. Each section (14, 16) comprises wavelength selectors (141, 142, . . . , 145 and 161, 162, . . . , 165) for wavelengths λ1, λ2, . . . , λn−k, where n≧3, λp< . . . <λn and λn−k+1, λn−k+2, . . . , λn being k≧1 emitting wavelengths of the laser (10). The laser further comprises an intracavity section (18) that is made of a non-linear optical medium, has a zero-dispersion wavelength λ0 and is disposed between the input (14) and the output (16) section. The wavelengths λ1, λ2, . . . , λn−k of the wavelength selectors (141, 142, . . . , 145 and 161, 162, . . . , 165) and the zero-dispersion wavelength λ0 of the intracavity section (18) are chosen such that energy is transferred between different wavelengths by multi-wave mixing.

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  • Methods for producing neuronal cells and uses thereof

    Green, Colin; Sherwin, Trevor; Chang, CYA (2010)

    Patent
    The University of Auckland Library

    Methods for producing neuronal cells, methods of treating or preventing ophthalmic diseases or conditions or of promoting recovery from an ophthalmic therapy, and methods of treating or preventing neurological diseases or conditions or of promoting recovery from a neurological therapy are provided. The methods involving treating ophthalmic cells, particularly corneal cells, with insulin, epidermal growth factor and fibroblast growth factor 2 for a period sufficient to trans-differentiate the cells to neuronal cells.

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  • Quinoline derivatives for modulating DNA methylation.

    Brooke, Darby; Phiasivongsa, P; Denny, WA; Gamage, S; Bearss, DJ; Vankayalapati, H; Redkar, SG (2009)

    Patent
    The University of Auckland Library

    (EN)Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. (FR)Cette invention concerne des dérivés de quinoline, en particulier des dérivés de 4-anilinoquinoline. Ces dérivés de quinoline peuvent être utilisés dans la modulation de la méthylation de l'ADN, par exemple dans l'inhibition effective de la méthylation de la cytosine en position C-5, par exemple par une inhibition sélective de l'ADN méthyltransférase DNMT1. L'invention concerne par ailleurs des procédés permettant de synthétiser plusieurs dérivés de 4-anilinoquinoline et de moduler la méthylation de l'ADN. L'invention concerne également des procédés permettant de formuler et d'administrer ces composés ou ces compositions pour traiter des pathologies comme le cancer et les troubles hématologiques.

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  • Methods and compositions for increasing storage-life of fruit

    Atkinson, R; Schaffer, Robert; Gunaseelan, K; Schroeder, R (2010)

    Patent
    The University of Auckland Library

    The invention provides methods and compositions for producing plants with fruit having increased post-harvest storage life, the method comprising reducing the expression or activity in the plant, of a polypeptide with the amino acid sequence of SEQ ID NO: 1(Malus domestica polygalaturonase, MdPG1), or a variant of the polypeptide. The invention provides host cells, plant cells and plants transformed with the polynucleotides of the invention. The invention also provides methods for selecting plants with fruit having increased postharvest storage life. The invention also provides plants produced and selected by the methods of the invention.

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  • Surface Injection Device

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, Dawn; Ball, NB; Hogan, NC (2010)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .

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  • Injection methods using a servo-controlled needle-free injector

    Hemond, BD; Hunter, IW; Taberner, Andrew; Wendell, DM; Hogan, NC (2014-06-03)

    Patent
    The University of Auckland Library

    A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

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  • Conformable antenna using conducting polymers

    Hunter, IW; Montemayor, L; Paster, ET; Pillai, P; Ruddy, BP (2012-02-16)

    Patent
    The University of Auckland Library

    Antenna including a wire made of a conducting polymer. The wire is sewn into fabric material in a selected pattern. A preferred conducing polymer is polypyrrole. It is also preferred that the Wire be encased in a non-conductive, low dielectric plastic.

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  • Bi-directional motion of a lorentz-force actuated needle-free injector (NFI)

    Hunter, IW; Taberner, Andrew; Hogan, NC (2015-09-08)

    Patent
    The University of Auckland Library

    The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

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  • Lorentz force linear actuator needle-free jet injection system to deliver solid and / or fluid

    Taberner, Andrew; Hunter, IW; Hogan, NC (2015-08-26)

    Patent
    The University of Auckland Library

    It means for conveying solids by the method of the surface of the organism, including (i) the electrical input applied to the controllable electromagnetic actuator; (ii) the actuator corresponding to said generated electrical machine with the electromagnetic input force; and (iii) applying mechanical force to the one end of the receptacle is coupled with the nozzle, the mechanical force generated pressure within the receptacle, with the magnitude of the pressure change and the mechanical force caused by the injection of fluid from the reservoir to drive solid into the organism. The method for delivering a substance to a target body, comprising (i) the needle-free injector near the surface of the target body; (ii) the substance injected into the target body; and (iii) at the same time injected, along the movement of the surface of the needle-free injector thus sweep the surface.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Hogan, NC; Ball, NB (2015-03-31)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2014-07-15)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Needle-free injector device with autoloading capability

    Hunter, IW; Hemond, BD; Wendell, DM; Hogan, NC; Taberner, Andrew; Ball, NB (2012-05-08)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.

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  • Needle-free transdermal transport device

    Ball, NB; Hemond, BD; Hogan, NC; Hunter, IW; Taberner, Andrew; Wendell, DM (2009-08-16)

    Patent
    The University of Auckland Library

    needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Surface injection device

    Taberner, Andrew; Hunter, IW; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2010-09-29)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-freetransfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .

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  • Controlled needle-free transport

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Hogan, NC; Ball, NB (2012-12-11)

    Patent
    The University of Auckland Library

    A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Surface injection device

    Hunter, IW; Taberner, Andrew; Hemond, BD; Wendell, DM; Ball, NB; Hogan, NC (2010-10-27)

    Patent
    The University of Auckland Library

    Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules with specially designed jet passages at the injector's distal end.

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  • Impaired wound healing compositions and treatments

    Becker, DL; Green, Colin; Duft, BJ (2011-11-22)

    Patent
    The University of Auckland Library

    Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.

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  • Diagnostically and audibly responsive computer learning memory game and system provided therefor

    Dowrick, Peter (2006)

    Patent
    The University of Auckland Library

    A diagnostically and audibly responsive computer learning memory game works with small children and other persons in teaching them to read. Square or rectangular tiles to be uncovered are displayed upside down, concealing words to be matched with words or words to be matched with phrases or visual pictures or audible sounds, objective is to find matching cards. The computer game matches the cards or tiles with sight words that the user is learning to read from a word list. The user must remember where a correct word of the word pairs is located. The user must read word orally, if not, the computer will prompt the user with a clue (such as the beginning sound of a word) until the user answers. If nothing is heard, the user is told the answer. The system has a built-in recording of a library of selected words, phrases, pictures or audible sounds. The computer can sense that user is silent (with a default of no sound). If a wrong word is uttered, the system can remain silent or correct..

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