79 results for Patent

  • Needle-free transdermal transport device

    Ball, NB; Hemond, BD; Hogan, NC; Hunter, IW; Taberner, Andrew; Wendell, DM (2009-08-16)

    Patent
    The University of Auckland Library

    needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

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  • Injection methods using a servo-controlled needle-free injector

    Hemond, BD; Hunter, IW; Taberner, Andrew; Wendell, DM; Hogan, NC (2014-06-03)

    Patent
    The University of Auckland Library

    A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

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  • Gastric Therapies and Compositions Thereof

    Roberton, AM; O'Connor, Charmian; Martin, Iain; Alany, Raid (2008)

    Patent
    The University of Auckland Library

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  • Substituted pyrimidines and triazines and their use in cancer therapy

    Rewcastle, Gordon; Shepherd, Peter; Chaussade, C; Denny, William; Gamage, Swarnalatha (2009)

    Patent
    The University of Auckland Library

    Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110?? isoform of PI3K.

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  • 1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

    Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

    Patent
    The University of Auckland Library

    The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

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  • Compressor Improvements

    McGill, IC; Boyd, JR; White, DJ; Patel, U; Bruce, CS; Read, TG; Otte, G; Bonniface, BR; Mallinson, Gordon (2008)

    Patent
    The University of Auckland Library

    Compressor having a single cylinder (15012) with an enclosed end defining a compression space, with a piston (15002,15004) reciprocating in said single cylinder, comprising: a plurality of gas flow paths (15008) from said compression space to a discharge space, a self operating valve (15020;17008) in each said gases flow path, opening under the influence of the prevailing pressure differential across the valve, and being biased to a closed condition by a spring (17006), each said valve and spring being part of a single unitary planar valve member (15020;17002).

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  • Cell marker of melanocyte cell lineage and uses thereof

    Dunbar, PR; Horlacher, O; Feisst, Vaughan (2009)

    Patent
    The University of Auckland Library

    The present invention relates to a novel protein that is a marker of melanocyte cell lineage and cancer cells, and to nucleic acids encoding the novel protein. The invention also relates to treatment of disorders of cells of the melanocyte lineage, and to compositions and methods for treatment of such disorders.

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  • Adrenocorticotropic hormone analogs and related methods

    Brennan, MB; Costa, Jessica; Dores, RM; Hochgeschwender, U; Haskell-Luevano, C (2007)

    Patent
    The University of Auckland Library

    ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.

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  • Heat Exchanger

    Taylor, Mark; Chen, John; Farid, M; Wallace, RJ (2014-07-15)

    Patent
    The University of Auckland Library

    A heat exchanger 10 includes a conduit 12 for conveying cooling fluid relative to a body to be cooled. A heat transfer arrangement 62 is arranged in communication with an interior of the conduit 12, the heat transfer arrangement 62 and the conduit 12 together defining an assembly that is mountable adjacent the body to be cooled, convective heat exchange occurring, in use, due to movement of the cooling fluid relative to the body and to the heat transfer arrangement 62 of the assembly and radiant heat exchange occurring between the body and at least part of the heat transfer arrangement 62 of the assembly.

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  • Contact lens packaging structure having myopia control agent

    Chiang, Samuel; Phillips, John (2016-10-11)

    Patent
    The University of Auckland Library

    Note this is a Translation from the original Chinese version. This authoring system to provide a package structure containing a contact lens myopia control agent (e.g., a mydriatic) of which comprises a base, a contact lens and a package film. Center of the base portion having a recess for accommodating the liquid, the liquid contained in the myopia control agent. Contact lenses provided in the recessed portion and is immersed in the liquid. Encapsulation film for closing the opening of the recessed portion.

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  • Automatic Optimal View Determination for Cardiac Acquisitions

    O'Donnell, T; Cowan, Brett; Young, AA (2004-11-08)

    Patent
    The University of Auckland Library

    A method, system, and apparatus of determining optimal viewing planes for cardiac image acquisition, wherein the method includes acquiring a set of sagittal, axial, and coronal images of a heart, where the axial and coronal images intersect with the sagittal image orthogonally, and where the heart has a natural axis and a left ventricle (???LV???) with a bloodpool, a bloodpool border, and an apex. The method also includes making a map of the bloodpool border, and using the map to create a full coordinate frame oriented along the natural axis.

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  • Method and system of measuring charateristics of an organ

    Young, Alistair; Cowan, Brett (2006-12-26)

    Patent
    The University of Auckland Library

    The invention provides a method of measuring characteristics of an organ or part thereof from multiple images of the organ or part thereof, the method comprising the steps of defining the spatial position of at least two of the images; defining a reference model of the organ or part thereof scaled according to the distance between reference markers on the images; defining one or more boundary guide points associated with one or more images for which the spatial positions have been defined; converting the guide points to three-dimensional coordinates; defining an estimate model by fitting the reference model to the guide points; and calculating the characteristics from the estimate model. The invention also provides a system and a computer program for measuring characteristics of an organ or part thereof of a subject from multiple images of the subject's organ or part thereof.

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  • Model Assisted Planning of Medical Imaging

    Cowan, BR; O'donnell, T; Young, Alistair (2005-01-13)

    Patent
    The University of Auckland Library

    A method (600) and system (700) for medical image acquisition are provided, where the method (600) includes acquiring an image of the region of interest (610), acquiring a model for a region of interest (620), and fitting the model to the image (630); the system (700) includes a modeling unit for modeling a region of interest (770); an acquisition unit in signal communication with the modeling unit for acquiring an image of the region of interest (732); and a fitting unit in signal communication with the acquisition unit for fitting the model to the image (780).

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  • Effects of Glycyl-2-methylprolylglutamate on Neurodegeneration

    Gluckman, Peter; Thomas, GB; Guan, J; Dragunow, M; Anand, Ashmit; Kerlero de Rosbo, N; Sieg, F; Brimble, Margaret (2007-12-27)

    Patent
    The University of Auckland Library

    This invention provides analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic, anti-necrotic and have neuroprotective effects. These agents are useful in treating neurodegeneration and behavioural disorders caused by toxins, traumatic brain injury and autoimmune disorders of the brain, such as multiple sclerosis and in reducing seizures.

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  • Tinnitus treatment system and method

    Searchfield, Grant; Kobayashi, Kei; Irving, Samuel (2011)

    Patent
    The University of Auckland Library

    A tinnitus masking system for use by a person having tinnitus. The system comprises a sound delivery system having left and right ear-level audio delivery devices and is configured to deliver a masking sound to the person via the audio delivery devices such that the masking sound appears to originate from a virtual sound source location that substantially corresponds to the spatial location in 3D auditory space of the source of the tinnitus as perceived by the person. The masking sound being represented by left and right audio signals that are converted to audible sound by the respective audio delivery devices.

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  • Interactive gaming system

    Searchfield, Grant; Kobayashi, Kei; Wise, KJ (2012)

    Patent
    The University of Auckland Library

    The present invention relates to an interactive gaming system for auditory training rehabilitation relating to tinnitus.

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  • Cognitive Enhancement and Cognitive Therapy Using Glycyl-L-2-Methylprolyl-L-Glutamic Acid

    Gluckman, Peter; Guan, Jian; Woodworth, M; Brimble, Margaret

    Patent
    The University of Auckland Library

    This invention provides compounds, compositions and methods for treating loss of cognitive function in animals that results from aging. In particular, compounds of this invention can stimulate neural cell growth, increased amounts of cells containing a key enzyme needed for production of the cholinergic neurotransmitter, and can improve memory and cognitive function in animals who have experienced a loss of memory or cognitive function as a result of aging.

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  • Neuroprotective Bicyclic Compounds and Methods for their Use

    Brimble, Margaret; Guan, Jian; Sieg, Frank (2005-03-17)

    Patent
    The University of Auckland Library

    Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

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  • System and method for tracking facial muscle and eye motion for computer graphics animation

    Sagar, Mark; Scott, R (2009)

    Patent
    The University of Auckland Library

    A motion tracking system enables faithful capture of subtle facial and eye motion using a surface electromyography (EMG) detection method to detect muscle movements and an electrooculogram (EOG) detection method to detect eye movements. An embodiment of the motion tracking animation system comprises a plurality of pairs of EOG electrodes adapted to be affixed to the skin surface of the performer at locations adjacent to the performer's eyes. The EOG data comprises electrical signals corresponding to eye movements of a performer during a performance. Programming instructions further provide processing of the EOG data and mapping of processed EOG data onto an animated character. As a result, the animated character will exhibit he same muscle and eye movements as the performer.

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