Immunization with adenoviral vectors carrying recombinant IL-12 and E7 enhanced the antitumor immunity against human papillomavirus 16-associated tumor.

Author: Park, EK; Kim, YW; Lee, JM; NamKoong, SE; Kim, DG; Chun, HJ; Han, BD; Bae, SM; Jin, Hyun Sun; Sin, JI; Ahn, WS

Date: 2005-02

Type: Journal article

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The University of Auckland Library


Human papillomavirus (HPV) infection has a significant role in cervical carcinogenesis, and HPV oncoprotein E7 plays an important part in the formation and maintenance of cervical cancer. Interleukin-12 (IL-12) has been reported to induce a cellular immune response, and to suppress the tumor growth and the E7 production. Here we describe the use of adenoviral delivery of the HPV 16 E7 subunit (AdE7) along with adenoviral delivery of IL-12 (AdIL-12) in mice with HPV-associated tumors.

Citation: ["Cancer Res Treat 37(1):63-70 Feb 2005"]