Methods of increasing radiosensitivity using inhibitors of trefoil factor 1 (TFF1)

Author: Lobie, Peter; Perry, Johanna

Date: 2012

Type: Patent

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The University of Auckland Library


The invention relates generally to the use of inhibitors of TTF1 to increase radiosensitivity of tumors and other cells. The invention provides methods of inhibiting proliferation or survival of a tumor cell; methods of treating, delaying the progression of, preventing a relapse of, or alleviating a symptom of a cancer or other neoplastic condition; methods increasing sensitivity of a tumor cell to radiotherapy; methods of enhancing or supplementing an anti-cancer therapy in a subject that is receiving or has been administered radiotherapy; and methods of inhibiting one or more activity or function of a TFF1 - stimulated cancer stem cell.

Citation: ["Patent/Trademark number: WO 2012/038825 A2 (United States). Application number: IB2011/002397. Filed date: 21 Sep 2011."]