1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

Author: Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

Type: Patent

Link to this item using this URL: http://hdl.handle.net/2292/27904

The University of Auckland Library

Abstract

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

Citation: ["Patent/Trademark number: 8,772,287 B2 (USA). Publication/Application date: 10 Jun 2013. Publication/Awarded date: 08 Jul 20"]

Copyright: https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm